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Conservative earlier thLs i. He made it clear, however, that he believed Arm. He preferred to stress freedom from government inicrferenci? John Paraue. Pardoe said Rin aoki porn etotic clips had 1 1 pea n bu- again. Lf we did not join Government in a difficult uur partners iu the system in linn. A Commons debale the New Year we would be been promised on the Euro- forced sooner or later to accept a Monetary System when a a i-mninan currency fashioned by siun is Rin aoki porn etotic clips in December others.

John Collins, managing director of Park West Motors, [ford. Essex, which imports Toyota cars, was delighted, if not a little surprised, by ihe news of ihe loan which will enable him lo buy xi new garage and.

The corporation was 3 little coy about the deal. This, departure mla imports financing was iustjfled largely on the hasis of Mr. Collins be.

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Collins did nut import Tuyotas. It said: Coilins said that when he applied for the loan he had expected the nature of hfs Rin aoki porn etotic clips to be a problem.

Finance had been difficult to find, but. Peter Foden-Pattin-: Conservative sun. Minet Agencies, and for Thanei East, about the Mr. Confidence was also expressed m Mr. Bernard Wex. The dispute over productivity is to be ihe subject of talks with Mr. It has also been the cause of warnings by the construction company that if payments con- tinue- to he withheld it Rin aoki porn etotic clips https://bendover.revia2018.host/pub11300-tinoky.php forced to Rin aoki porn etotic clips the pro- ject, which.

British Bridge Builders ruled twu weeks ago that if the Free- man Fox targets were not met the cable spinners would lose bonus payments equivalent lo about one third of weekly earnings.

Haydon Glen, clerk to the Board, said that outstanding issues in the dispute would have to be- settled by arbitration or in the High Court. British Industry indicated last The campaign was formed in night that ii took seriously pro- response to Rin aoki porn etotic clips Labour document, posals by sections of the Labour suggesting a National Construc- Party for nationalisation of the tion Corporation on the lines of building industry.

Erie Heffer, thai Labour should argue for step-by-slep public ownership of the construction industry. However, the Labour Party planned nationalisation. Water workers. The employer f had to provide the season ticket years ago and most annual sea- son tickets were now bought. Lins it Dispute delays frigate launch which would not be cashable by the employee, and he could not reimburse him for a ticket already bought. The frigate represent a key public sector Brilliant was to have been group in the low-pay area which Rin aoki porn etotic clips next week.

British Finally, the employee's Rin aoki porn etotic clips Mr. The Inland Revenue said yesterday Rin aoki porn etotic clips additional qualifi- cations. And it was likely most of the Discussion ranged round im- proving productivity by natural wastage. The management is stilt Rin aoki porn etotic clips to reduce go here labour force by several thousand. Talks on this are At yesterday's meeting of Iho expected to take weks.

The question of Rin aoki porn etotic clips cate- gories of workers make up ihe grades — and their rates — has stili not been settled. Saturday night shift, it added. Heffer was ownership, as the TUC had pru- addressmg. TASS, the engineering sluff union, yesterday issued a strong denial of charges reported to have been made last weekend by Mr. Michael Edwardes. BL chairman.

TASS national lift. He Is ton. Rudolph Agnew, deputy chairman, said yesterday that the study would be finished in a matter of weeks. The venture would be on a small scale, producing less than half the amount of tin -of Wheal Jane, near Truro.

Wheal Jane had an output of That mine is now on a care- and-malatenance basts after production. Robert L. Sprinkel— bis reluctance to accept Government money and the fact that he is willing tu put his own money ih, H Said Lord Erroll of Hale, the ehairman. Bat he held to the basic Gold Fields position on Wheal Jane: Bnt Lord Errol!

As far as other Cornish activities are concerned. Gold Fields is evaluating the results of drilling at two neglhbonring sites. ICI said yesterday that it did not yet have firm plans for the site, but it could follow the pattern of its biggest petro- chemicals site at Wilton on Teeiside. Products could include ammo nia and methanol— derived from natural gas — as wel-1 as oiher basic petrochemicals and down- stream products such as plasucs and fibres.

It is also involved in exploration pro grammes on various parts of the UK continental shelf In the North Sea and to the west oF the Shetlands. It has developed more than 1. Il is thought however, that ICI is anxious not to concentrate its resources too heavily In one area.

It has carried out land and seabed surveys at an estuary site in Tayside, Scotland. The site is at Barry Buddon. The company is also under stood to have investigated the Humber estuary in England.

Both the Humber and Tay offer sites with fiat land and access Rin aoki porn etotic clips. The com puny has held a series of dis- cussions with the Scottish Office shout the Tayside location. First news of the plan has already brought mixed reactions from local interests on Tayside. Dundee has high unemployment It might therefore be expected 3 hili 1 in spa,n - The deposit certificates trial. He was jointly charged. Felicio Morelia, the former Banking Corporation and its head of both international Bank, associated company, European ing and European and Arabian, and Arabian Bank, both regis- who was jailed for three years tered in Anquilia.

Unterlaggauer has prison sentence at the Old Bailey, spent 12 months in custody, he Dr. Heinrich Peter Unlertag- will be released on Honda when gauer, born In Austria, Rin aoki porn etotic clips a riepnrtatinn order will be con- pleaded guilty to charges of issu- sirlcrert.

He claims io have Rin aoki porn etotic clips ing false certificates of deposit job awaiting him in Germany, in order to acquire seven hotels Mr. Joseph Khalife is still on in Spain. The deposit certificates trial. He Detective Chier Inspector Roy has pleaded no't guilty. Elsey, he admitted signing 15 European and Arabian Bank certificates — together with has no connection with the another former employee of European Arab Bank group International Banking Corpora- Industrial Banking Cornoration" non who has since left the UK.

Uo terlaggauer's sentence the c ame name. EG Commission to make their eipalities: Most of the steel in an average British car body is sheet steel. There was little to cheer in the silt market either, as a further rise in U.

Interest rates British interest rates are still high enough to attract inflows from the United States, even after the most recent rise in the U. As the forward discount on ster- ling has shrunk almost to par. On a Rin aoki porn etotic clips level, it does seem that confidence in sterling, as against lack of confidence in the dollar, has been growing over the last week, with the foreign exchange markets appealing rather less worried about news on the labour front.

There article source been some nervous- ness i hat the Bank of England might intervene to stop sterling rising fun her. Next week the official cur- rency reserve figures for October will be published, and Rin aoki porn etotic clips are expected to show that the Bank's intervention has been limited. But any sign aF funds flowing heavily into London could be worrying to the markets, unless of course foreign money flows into gilts and encourages the home-based institutions tu jump in too.

At the moment, though, short money rates are so high that they weaken the inducement to commit money to gilts. Drug problems Beecham's share price took a rumble last week on news that the Rin aoki porn etotic clips may bo forced to cut its drug prices further in the U.

Analysts, on lie other hand, feel the market reaction may be somewhat overdone. The issues arc undoubtedly complex and involve a fair bit of unfinished litigation. Beecham, for example, is still suing its main U. But Bristol and Beecham have both been on the receiving end under U. It comes, moreover, in the wake of average amoxy- cillin price cuts since July of roughly 20 per cent. This has already been noted by dose ob- servers of the U.

In the short term, despite some loss in market share. Although longer term growth prospects from the U. After sliced bread Now that the loss-making bread baking business is out of the way. A 98 Offer from Wm. Baird lapsed De Beers Dfd. Group Just click for source Gp.

Blacked xvideoيوتيوب Watch Video Xxx Animaux. The bulk of these were under 1. Secondly, the Mothercare management in the U. Strenuous efforts, including top management changes, are now going on to turn the pro- ject round. And meanwhile the stores operating under the Mothercare name are apparently doing well. Impressive though ' the Dow's losses have been in the last two weeks, they in fact understate the broad market decline, notably the routing of secondary stocks. The American Stock Exchange which hosts many' of the smaller, less capitalised companies, has seen its index tumble by a formidable 17 per cent front its peak in mid- September, while the Dow has suffered a more modest 9. On Thursday the Dow drew back by 9. But yesterday the decline quickened and the Dow dropped Technical analysts looking for a rainbow claim they are only mildly surprised at the slaughter. They point out that before the rally which started last April the market bad been seriously weakened by the Blue Chips — the IB Ms and Polaroid; of this world — while the smaller stocks had shown positive strength for most of last year. Meanwhile, away from the technicians' charts investors have found that the world is too much with them. In a brief but grisly recap the week's news has included a rise in commercial hanking prime rates to per cent, the. A 19th-century Russian novelist would have been strained to write a more depressing scenario There is as much scepticism in the U. Somewhat curiously there has been no attempt berc to cite the achievements of Britain's voluntary policy in justification for the new approach when on the surface the prospects for success are at least as good as they were in Britain. When they have been at their most negative they have simply assumed that conditions have been so bad. Perhaps the time has come again to search for a new meta- phor. The latest batch of quarterly results from North American groups show- a dis- tinct improvement over a year ago, if not in profits at least in sales. It is tempting to see the figures as the definite start nf a new trend, but the U. Another of the U. It came back into Ihe black in the second quarter and in the three months to No. The said Minute is in lhe wordsand figures following: Charles Barber, the Asarco chairman. Tm iD the same three mouths of Although zinc prices hafe been at lower levels than last year, lead demand has been strong and looks like remaining so. Further evidence nf the revival in the copper industry came from Freeport Minerals, whose profits in the September quarter jumped sharply to S7. In contrast the market for tin has been consistently strong. But this bas not provoked any consistent rise in Malaysian production, as the accamsnyiaz fable shows. A combination of higher taxes ami. Sprinkel publicly to disclose his intention of try- ing to put together a financial package allowing him to take- over the Wheal Jane tin mine in Cornwall. Sprinkel is an American entrepreneur, now resident in Derbyshire, and within the next two weeks he hopes to make Consolidated Gold Fields, the present owners, a definite offer. Ayer Hitam - Be r junta! Piran — Far East St. Piran— UK South Crafty Southern Malayan Tanjong Tong kah Harbour 42 40 Tronoh i Figures hi elude low-grade material f Not yet a puts are shown in metric tonnes of tin concentrates. Sept, Atut. Another metal which has strengthened its price despite the recession is molybdenum. A in ax. This level was reached four months before bullion peaked ar SI Political factors arc one reason for the poor general per- formance of golds. A good ex- ample of the short-term effects arose last week, during the visit of the five western foreign ministers to Pretoria. On tiie Wednesday, the gold price hit a new record las it then was of S Politics, however. Mine violence has died down, the mine- have obtained a better spread of labour, which five years ago ua. One overriding reason for the low level of interest in golds is ihe growth of ihe gold furures markets in the U. In these markets did not exist and physical gold ownership was only authorised early in So gold shares — U. Wnn trading in the U. This aside. The table shows U. The top 15 account for R5. However, the table shows the U. In addition to U. There has also been a massive flow of De Beers shares to the U. Johannesburg brokers estimate 10 per cent of De Beers is now held in the U. Except to the U. With the local institutions traditionally more interested in industrials than golds and the European investor virtually out nf the market for a mixture of political and financial. But the counter- pull of the future markets and the high existing level of U. Gcfinlrl 45 Western Holds. Brand 24 66 Pres. Totals 5, Tx Gar t m ore Fmxl Managers Lid. Eamonn Fingleton iks at ways to cut the cost. But unless you are care- you will lose about T per of your capital in dealing ; every time you switch, point is thai the dealing of a switch is often the difference between the r" price at which unit: He needs to choose a? Jives tors who get into units. These can he useful when the outlook for shares turns choppy. With some groups— Hambro. First switch free. Cutting the bother of Child Benefits ing in various types of equities Some unscrupulous brokers for bond investors. Barclays have been criticised recently for Unicorn bondholders cannot drumming up commission by link their investment to any encouraging unnecessary switch- particular unit trust but instead ing. Such brokers are unlikely it is put in a managed fund invested in a selection of the group's trusts. The managers vary the mix as market conditions dictate. Barclays, for instance, usually deducts in full the amount of any commis- for cent initial commission introducing new business. Indications for the second and third weeks arc that sales are lower, bill still very strong. The sudden sales surge re- flects the fact that -from October 1. Yet this jump in sales no- where near represents the full potential that could have taken place. There are about lira persons holding these certifi- cates, of whom over lm held the maximum holding before October 1. Looking to the immediate future' and the likely movement in the Retail Price Index, the official forecasts are that the year-on-year increase will re- main around S per cent for the next six months. But unofficial forecasts of r the rise of the RPI in the next 12 months vary from 6 to 12 per cent depending on the view on forthcoming wase settlements. Stockbrokers Phillips anti Drew, for example, is forecasting an They have lo watch patiently as the assistant goes through the palaver of stamping the benefit book, removing a counterfoil and counting our the money. The procedures are more appropriate in the days of the Penny Black than to an institu- tion that is now loading the world in such high-tech oology fields as Viewdata. From the outside, one would have though! And for working mothers in particular — who are more likely than stay-at-home wives to have their own bank accounts — the freedom from The need to traipse regularly to the Post Office would be a major boon. The Department of Social Security secs immense obstacles but it admitted this week that it has at least begun to study seriously the possibility of pay- ing the benefits by credit trans- fer where a mother so desiTes. The officials are also looking at the question of paying the Old Age Pension by credit trans- fer. The proportion of pen- sioners who bave bank accounts is lower than for the active population: No figures are available but the Department seems to fear that the savings to it later on would not com- pensate for the extra expenses early on. Two payment systems would involve a great deal of duplication of effort, the Depart- ment adds. But it is not as if the sums the Department is paying nui are small: The Depart- ment is pressing ahead with cninnilinc a report for ministers. But such a dogmatic view- point seems to assume that husbands and wives are con- stantly bickering over ihe house- keeping money. Any wife who is happy about the way the family's finances are shared out and does not agree that this view is typical will feel insulted that the Slate does nut allow her to make up her own mind on whether ihe money should be paid into a joint account Bankers feel that there may be one other reason why Social Security officials may be luke- warm about introducing credit transfers: But the cost of disposing of cash is a small price to pay for the extra convenience for mother and pensioners. The objective of the Allied Hambro Pacific Fund is to obtain long term capital growth by investing: It enables you to invest in Singapore, Malaysia and the Philippines Ji a ve offered considerable potential for economic growth. Now a number of countries in this area huve begun to achieve their potential, and in recent years have shown remarkable growth rates, often twice that of many major industrialised countries. Until a few years ago political instability in the area was a major deterrent to investment. But while there is some risk of recurring political disturbances, the political climate, particularly following China's policy of improving relations with its neighbours, now appears more stable. At the same time, there is now within this area a. Oriom Ovmm Couninm Svtiru Pacdtr 1-ld. Swim TropotOoi Lid. V Wimor Industrial Corn. Malayan Banking fifed. The objective is to maximise long-term capital growth; income is not a consideration. The improving prospects of the area have already been reflected in rising stock market values during this year. While we consider that the prospects for growth will continue, you should bear in mind tbat investment in these markets con be subject to substantial short-term fluctuations. We recommend therefore that an investment in the fund should form only part of a balanced portfolio. That having been said, the advantages of investing in South East Asian marked through an authorised unit trust are powerful indeed, in terms of simplicity, convenience and spread of risk. An investment in the fund should be regarded as a long-term one. Remember the price of units and the income from them may go down as well as up. You should also note that currency movements can significantly affect the value of your investment. How to invest Investment opportunity To take advantage of opportunities to invest in companies operating in this area of potential growth, and to avoid the pitfalls, the experience of full-time. The portfolio 'is currently heing invested in the shares of companies quoted or operating in Hong Kong. Singapore, Malaysia and the Philippines, including companies registered in London or elsewhere which. You will be allocated units to the full value of your remittance at the offer price ruling on receipt of your application. Units in the fund may also he acquired on a Tegular monthly basis. For further details complete and return the coupon below, ticking the appropriate box. Uni La may normally be bought and nofel on any Lw mrUnK to. SeUlnff units. RtcUMit oAn u. I wish to invest Sifegiunlf. Thr Trvrtoe u! Chorees- The offer nricr cvmnll. The charge is currently lS. Xtuun appltatlicBi is granted, umtholden fat the bail will be asked to approve the anffopnatemerease. J declare that I am over 18 sod am not resident outside the UK or other Scheduled Tern tones and that I am not acouinna die above units es the. If you ere unable to malic ihe residential declaration it should be deleted and the form lodged through your UK bank, stockbroker or solicitor. This Offer is not available to residents of the Republic of Ireland. The Director nf Fair Trading. Gordon Borrie. It is also satisfied with the new regulations for the control of insurance brokers. Here it feels that There is room for chanses to avoid the quick kill type of sales, by spreading the initial commission over. The Department of Trade has been pursuing this same line with the LOA, which up tu nuw has adupted an air that all is well. The OFT states quite categorically that front rhe complaints it receives all is not well. But one word of advice to the OFT. If it analyses the source of complaints closely, it will most likely find that the main offenders are the sales forces of life companies that are not members of the LOA. And if the experience nf the Prudential, the Pearl and the Co-operative are anything to go by any proposed change in com- mission is likely to be. These companies, mem- bers of the LOA, wanted to. It took a long time and a hard atrugste to implement the change. Rise in Gross Domestic Product. The other i? This is a good time to invest in the Fund. Remember that the price of units and the income from them can go down as well as up. Investment in a unit trust should be regarded as long term. To invest simply fill in the coupon and send it to us with your cheque. A final point. He will tell you that few unit trust groups can match Allied Hambro for its Far Eastern expertise. He will also explain the fundamental investment factors which make the Pacific area so attractive today. Units will be allocated at the offer price ruling on receipt of your application. For your guidance, on 23rd October at an offer price of The Trust Dnad empowers the Managers, lo include an inriial service chnrgeo! You may sell all or patrol your unit holding back TO the Managers at not lese than the bid price. You will bo sent a cheque in uttlenunl within seven business days of receipt by the Managers of your renounced unit certificate 5 Managers: Rayleigti Raid. Telephone orders to Ol 2S51 or Brentwood MR, MRS. In addition: The right financing package The balance of dollar premium and loan, components of the Trust will be regularly reviewed sothat the unit price reflects portfolio performance as closely as possible. The gross yield is cow estimated at 2. They also have long experience of fund management mNorth America. You can buy units by completing the application form and sending it with your cheque for the arnountyou wish to Invest. You will be allocated units at the price ruling when, your application is received. We will send you a contract note within a few days tellirfcyoa the number and price of units allocated. You can normally expect to receive the certificate -within a month of purchase. First distribution will be on 30tfa April Vfi9. Units may be bought and 3 nld at the prevailing oBer and bid prices, and yield, which are published daily in leading nev. The offer price of units iroimjff. To seQ your units, simply return your certificate endorsed on the bar k. You will n? The management company is Craigmount Unit Trust Managers. The Bank of Scotland, The Mound. Edinburgh is the Trustee. Registered office: A number of those shares - AMI and whose owner is unknown. Then future date to be agreed. Do the documents which you might not have involved go to a central office? What would redemption — an application for happen If the local authority a search of the tithe map might compulsorily purchased yield a past owner's naxue. I have a right of way over my neighbour's land. Surmics MriMrsCvIbo. I jnvweare o' , or IS. Is there any yardstick for h, k h ,. The mortgagor bor- cent and 99 per cent based on rower should retain only a rateable values. The landlords copy of the mortgage deed. What can one do please? Y ' T There is no such yardstick as. Self- thmk that your points fa help mav prove a false economy. The local ' No fejol aiso be lodged with you or your it as an obstruction to your by position; techhicaliy to pursue agent. The mortgagor bor- right of way. There is however? Independent attitudes survive ;: IN5sO arise. The landlords have no catioa is still flourishing having power to prevent the tenants survived more or Jess intact the forming an association. But very 5. Howard,' ft. These limited results flated from the effect of the over Not unexpectedly, die. ORS groups made use of -the indepen- dent sector for the education of their children. Last week, lead- ing school fee specialists C farms. This means that both preference shares and Government securities are attractive investments for two important reasons. Firstly they offer a high immediate income. Secondly they offer scope for capital growth since the strengthening of sterling and continued economic recovery should reduce the general level of interest rates over the coming months. In order t to obtain consistently high income most T of the portfolio is invested in preference I shares but the. K when compared with direct investment in r these, securities.. The price of tatiu and the income from them can go down as well as up. Unus will be available after the offer doses at tbe nor- ms! Commission of ii? An initial charge of j? ContracrooceswiD be issued and unit certificates vitlbe forwarded wnbiB six weeks of payment. Managers Henderson Unit Trust. Q-N Registered Office. Your income will- be paid half-yearly At the end-of the. It- fs she. Higher Rate taxpayers may have their liability to tax reduced, deferred or. The Company reserves the right- to discontinue or revise the terms quoted in 'the light- of future investment conditions. After the close Scheme piwidea a tygPjf of this offer units will be available at the daily quoted price. The tables show how this is being done. Private education is not exclusively for the rich. Many families not only are prepared to make financial sacrifices, they are actually making those sacrifices- Families can help to meet l. D P TIQ. I am over 18 yean of age and understand that this Applica- tion Form shall be the basis of the. Insddi type of -: Think of the garden iigh- speed saving or the overs You invest in a tor could expect to receive [root: So the contribution scheme compared " thcr your tax bracket. The projected pay land Revenue. Not only is ly ten years membership of a tbe investor paying a greater - heme: The com a tax-free lump sum is pany passing on the benefit or owed to anyone with 20 years' investment in a tax-exempt "mbership. But there are drawbacks. Once an investor has paid the contributions the money cannot be touched until he retires or until his death, if earlier. He cannot use it like a building society account. The investor may not be aleb to take the a ,ch year of sen - ice. Consider Die case or a man ced 45 joining the pension heme. He will qualify for But he is lowe dthe maximum i-ommuta- on of one-and-a-half times finaJ Jaiy. And the cash sum. It depends very much on whether the amount exceeds the limits Tor commutation. It is a Revenue con ditidn that contributions should be paid for at least five years or until ' normal retirement ' if earlier. Overall contributions are limited to 15 per cent ; of salary, including what the mem-: And the scheme has to be established by the employer. Most employers, even those with seif-administered schemes, prefer to provide voluntary contributions through a life company. It is administratively simpler and avoids the prob- lems of setting up a separate in- vestment fund. A bewildering variety of schemes is at present being marketed. Life companies do their best to explain hu utthese schemes work, but with varying degrees of success. However, the Society estimates that because the investment is tax-free, the value of units will be more than double the amount of net premiums paid over ten years. So far, it has performed much better than this. For further details,- please fill in the coupon below: Julian Gibbs Associates Limited. Start to buy all iWe to normally insured perils. The site is at Barry Buddon. The company is also under stood to have investigated the Humber estuary in England. Both the Humber and Tay offer sites with fiat land and access to. The com puny has held a series of dis- cussions with the Scottish Office shout the Tayside location. First news of the plan has already brought mixed reactions from local interests on Tayside. Dundee has high unemployment It might therefore be expected 3 hili 1 in spa,n - The deposit certificates trial. He was jointly charged. Felicio Morelia, the former Banking Corporation and its head of both international Bank, associated company, European ing and European and Arabian, and Arabian Bank, both regis- who was jailed for three years tered in Anquilia. Unterlaggauer has prison sentence at the Old Bailey, spent 12 months in custody, he Dr. Heinrich Peter Unlertag- will be released on Honda when gauer, born In Austria, had a riepnrtatinn order will be con- pleaded guilty to charges of issu- sirlcrert. He claims io have a ing false certificates of deposit job awaiting him in Germany, in order to acquire seven hotels Mr. Joseph Khalife is still on in Spain. The deposit certificates trial. He Detective Chier Inspector Roy has pleaded no't guilty-. Elsey, he admitted signing 15 European and Arabian Bank certificates — together with has no connection with the another former employee of European Arab Bank group International Banking Corpora- Industrial Banking Cornoration" non who has since left the UK. Uo terlaggauer's sentence the c ame name. EG Commission to make their eipalities: Most of the steel in an average British car body is sheet steel. There was little to cheer in the silt market either, as a further rise in U. Interest rates British interest rates are still high enough to attract inflows from the United States, even after the most recent rise in the U. As the forward discount on ster- ling has shrunk almost to par. On a simpler level, it does seem that confidence in sterling, as against lack of confidence in the dollar, has been growing over the last week, with the foreign exchange markets appealing rather less worried about news on the labour front. There has been some nervous- ness i hat the Bank of England might intervene to stop sterling rising fun her. Next week the official cur- rency reserve figures for October will be published, and they are expected to show that the Bank's intervention has been limited. But any sign aF funds flowing heavily into London could be worrying to the markets, unless of course foreign money flows into gilts and encourages the home-based institutions tu jump in too. At the moment, though, short money rates are so high that they weaken the inducement to commit money to gilts. Drug problems Beecham's share price took a rumble last week on news that the company may bo forced to cut its drug prices further in the U. Analysts, on lie other hand, feel the market reaction may be somewhat overdone. The issues arc undoubtedly complex and involve a fair bit of unfinished litigation. Beecham, for example, is still suing its main U. But Bristol and Beecham have both been on the receiving end under U. It comes, moreover, in the wake of average amoxy- cillin price cuts since July of roughly 20 per cent. This has already been noted by dose ob- servers of the U. In the short term, despite some loss in market share. Although longer term growth prospects from the U. After sliced bread Now that the loss-making bread baking business is out of the way. A 98 Offer from Wm. Baird lapsed De Beers Dfd. Group Financial Gp. So loss elimination should be worth Elsewhere the milling division did better, and grocery products and meat are singled out as having done well. The one question for the market is haw quickly Spillers will restore its dividead. Last year when profits collapsed the dividend was slashed from 2. The market is banking on Spillers going some way to restoring the divi- dend this year. For the whole of last year losses in the U. This left group profits only. The problems seem to have been twofold. First, Mothercare j set up its U. The bulk of these were under 1. Secondly, the Mothercare management in the U. Strenuous efforts, including top management changes, are now going on to turn the pro- ject round. And meanwhile the stores operating under the Mothercare name are apparently doing well. Impressive though ' the Dow's losses have been in the last two weeks, they in fact understate the broad market decline, notably the routing of secondary stocks. The American Stock Exchange which hosts many' of the smaller, less capitalised companies, has seen its index tumble by a formidable 17 per cent front its peak in mid- September, while the Dow has suffered a more modest 9. On Thursday the Dow drew back by 9. But yesterday the decline quickened and the Dow dropped Technical analysts looking for a rainbow claim they are only mildly surprised at the slaughter. They point out that before the rally which started last April the market bad been seriously weakened by the Blue Chips — the IB Ms and Polaroid; of this world — while the smaller stocks had shown positive strength for most of last year. Meanwhile, away from the technicians' charts investors have found that the world is too much with them. In a brief but grisly recap the week's news has included a rise in commercial hanking prime rates to per cent, the. A 19th-century Russian novelist would have been strained to write a more depressing scenario There is as much scepticism in the U. Somewhat curiously there has been no attempt berc to cite the achievements of Britain's voluntary policy in justification for the new approach when on the surface the prospects for success are at least as good as they were in Britain. When they have been at their most negative they have simply assumed that conditions have been so bad. Perhaps the time has come again to search for a new meta- phor. The latest batch of quarterly results from North American groups show- a dis- tinct improvement over a year ago, if not in profits at least in sales. It is tempting to see the figures as the definite start nf a new trend, but the U. Another of the U. It came back into Ihe black in the second quarter and in the three months to No. The said Minute is in lhe wordsand figures following: Charles Barber, the Asarco chairman. Tm iD the same three mouths of Although zinc prices hafe been at lower levels than last year, lead demand has been strong and looks like remaining so. Further evidence nf the revival in the copper industry came from Freeport Minerals, whose profits in the September quarter jumped sharply to S7. In contrast the market for tin has been consistently strong. But this bas not provoked any consistent rise in Malaysian production, as the accamsnyiaz fable shows. A combination of higher taxes ami. Sprinkel publicly to disclose his intention of try- ing to put together a financial package allowing him to take- over the Wheal Jane tin mine in Cornwall. Sprinkel is an American entrepreneur, now resident in Derbyshire, and within the next two weeks he hopes to make Consolidated Gold Fields, the present owners, a definite offer. Ayer Hitam - Be r junta! Piran — Far East St. Piran— UK South Crafty Southern Malayan Tanjong Tong kah Harbour 42 40 Tronoh i Figures hi elude low-grade material f Not yet a puts are shown in metric tonnes of tin concentrates. Sept, Atut. Another metal which has strengthened its price despite the recession is molybdenum. A in ax. This level was reached four months before bullion peaked ar SI Political factors arc one reason for the poor general per- formance of golds. A good ex- ample of the short-term effects arose last week, during the visit of the five western foreign ministers to Pretoria. On tiie Wednesday, the gold price hit a new record las it then was of S Politics, however. Mine violence has died down, the mine- have obtained a better spread of labour, which five years ago ua. One overriding reason for the low level of interest in golds is ihe growth of ihe gold furures markets in the U. In these markets did not exist and physical gold ownership was only authorised early in So gold shares — U. Wnn trading in the U. This aside. The table shows U. The top 15 account for R5. However, the table shows the U. In addition to U. There has also been a massive flow of De Beers shares to the U. Johannesburg brokers estimate 10 per cent of De Beers is now held in the U. Except to the U. With the local institutions traditionally more interested in industrials than golds and the European investor virtually out nf the market for a mixture of political and financial. But the counter- pull of the future markets and the high existing level of U. Gcfinlrl 45 Western Holds. Brand 24 66 Pres. Totals 5, Tx Gar t m ore Fmxl Managers Lid. Eamonn Fingleton iks at ways to cut the cost. But unless you are care- you will lose about T per of your capital in dealing ; every time you switch, point is thai the dealing of a switch is often the difference between the r" price at which unit: He needs to choose a? Jives tors who get into units. These can he useful when the outlook for shares turns choppy. With some groups— Hambro. First switch free. Cutting the bother of Child Benefits ing in various types of equities Some unscrupulous brokers for bond investors. Barclays have been criticised recently for Unicorn bondholders cannot drumming up commission by link their investment to any encouraging unnecessary switch- particular unit trust but instead ing. Such brokers are unlikely it is put in a managed fund invested in a selection of the group's trusts. The managers vary the mix as market conditions dictate. Barclays, for instance, usually deducts in full the amount of any commis- for cent initial commission introducing new business. Indications for the second and third weeks arc that sales are lower, bill still very strong. The sudden sales surge re- flects the fact that -from October 1. Yet this jump in sales no- where near represents the full potential that could have taken place. There are about lira persons holding these certifi- cates, of whom over lm held the maximum holding before October 1. Looking to the immediate future' and the likely movement in the Retail Price Index, the official forecasts are that the year-on-year increase will re- main around S per cent for the next six months. But unofficial forecasts of r the rise of the RPI in the next 12 months vary from 6 to 12 per cent depending on the view on forthcoming wase settlements. Stockbrokers Phillips anti Drew, for example, is forecasting an They have lo watch patiently as the assistant goes through the palaver of stamping the benefit book, removing a counterfoil and counting our the money. The procedures are more appropriate in the days of the Penny Black than to an institu- tion that is now loading the world in such high-tech oology fields as Viewdata. From the outside, one would have though! And for working mothers in particular — who are more likely than stay-at-home wives to have their own bank accounts — the freedom from The need to traipse regularly to the Post Office would be a major boon. The Department of Social Security secs immense obstacles but it admitted this week that it has at least begun to study seriously the possibility of pay- ing the benefits by credit trans- fer where a mother so desiTes. The officials are also looking at the question of paying the Old Age Pension by credit trans- fer. The proportion of pen- sioners who bave bank accounts is lower than for the active population: No figures are available but the Department seems to fear that the savings to it later on would not com- pensate for the extra expenses early on. Two payment systems would involve a great deal of duplication of effort, the Depart- ment adds. But it is not as if the sums the Department is paying nui are small: The Depart- ment is pressing ahead with cninnilinc a report for ministers. But such a dogmatic view- point seems to assume that husbands and wives are con- stantly bickering over ihe house- keeping money. Any wife who is happy about the way the family's finances are shared out and does not agree that this view is typical will feel insulted that the Slate does nut allow her to make up her own mind on whether ihe money should be paid into a joint account Bankers feel that there may be one other reason why Social Security officials may be luke- warm about introducing credit transfers: But the cost of disposing of cash is a small price to pay for the extra convenience for mother and pensioners. The objective of the Allied Hambro Pacific Fund is to obtain long term capital growth by investing: It enables you to invest in Singapore, Malaysia and the Philippines Ji a ve offered considerable potential for economic growth. Now a number of countries in this area huve begun to achieve their potential, and in recent years have shown remarkable growth rates, often twice that of many major industrialised countries. Until a few years ago political instability in the area was a major deterrent to investment. But while there is some risk of recurring political disturbances, the political climate, particularly following China's policy of improving relations with its neighbours, now appears more stable. At the same time, there is now within this area a. Oriom Ovmm Couninm Svtiru Pacdtr 1-ld. Swim TropotOoi Lid. V Wimor Industrial Corn. Malayan Banking fifed. The objective is to maximise long-term capital growth; income is not a consideration. The improving prospects of the area have already been reflected in rising stock market values during this year. While we consider that the prospects for growth will continue, you should bear in mind tbat investment in these markets con be subject to substantial short-term fluctuations. We recommend therefore that an investment in the fund should form only part of a balanced portfolio. That having been said, the advantages of investing in South East Asian marked through an authorised unit trust are powerful indeed, in terms of simplicity, convenience and spread of risk. An investment in the fund should be regarded as a long-term one. Remember the price of units and the income from them may go down as well as up. You should also note that currency movements can significantly affect the value of your investment. How to invest Investment opportunity To take advantage of opportunities to invest in companies operating in this area of potential growth, and to avoid the pitfalls, the experience of full-time. The portfolio 'is currently heing invested in the shares of companies quoted or operating in Hong Kong. Singapore, Malaysia and the Philippines, including companies registered in London or elsewhere which. You will be allocated units to the full value of your remittance at the offer price ruling on receipt of your application. Units in the fund may also he acquired on a Tegular monthly basis. For further details complete and return the coupon below, ticking the appropriate box. Uni La may normally be bought and nofel on any Lw mrUnK to. SeUlnff units. RtcUMit oAn u. I wish to invest Sifegiunlf. Thr Trvrtoe u! Chorees- The offer nricr cvmnll. The charge is currently lS. Xtuun appltatlicBi is granted, umtholden fat the bail will be asked to approve the anffopnatemerease. J declare that I am over 18 sod am not resident outside the UK or other Scheduled Tern tones and that I am not acouinna die above units es the. If you ere unable to malic ihe residential declaration it should be deleted and the form lodged through your UK bank, stockbroker or solicitor. This Offer is not available to residents of the Republic of Ireland. The Director nf Fair Trading. Gordon Borrie. It is also satisfied with the new regulations for the control of insurance brokers. Here it feels that There is room for chanses to avoid the quick kill type of sales, by spreading the initial commission over. The Department of Trade has been pursuing this same line with the LOA, which up tu nuw has adupted an air that all is well. The OFT states quite categorically that front rhe complaints it receives all is not well. But one word of advice to the OFT. If it analyses the source of complaints closely, it will most likely find that the main offenders are the sales forces of life companies that are not members of the LOA. And if the experience nf the Prudential, the Pearl and the Co-operative are anything to go by any proposed change in com- mission is likely to be. These companies, mem- bers of the LOA, wanted to. It took a long time and a hard atrugste to implement the change. Rise in Gross Domestic Product. The other i? This is a good time to invest in the Fund. Remember that the price of units and the income from them can go down as well as up. Investment in a unit trust should be regarded as long term. To invest simply fill in the coupon and send it to us with your cheque. A final point. He will tell you that few unit trust groups can match Allied Hambro for its Far Eastern expertise. He will also explain the fundamental investment factors which make the Pacific area so attractive today. Units will be allocated at the offer price ruling on receipt of your application. For your guidance, on 23rd October at an offer price of The Trust Dnad empowers the Managers, lo include an inriial service chnrgeo! You may sell all or patrol your unit holding back TO the Managers at not lese than the bid price. You will bo sent a cheque in uttlenunl within seven business days of receipt by the Managers of your renounced unit certificate 5 Managers: Rayleigti Raid. Telephone orders to Ol 2S51 or Brentwood MR, MRS. In addition: The right financing package The balance of dollar premium and loan, components of the Trust will be regularly reviewed sothat the unit price reflects portfolio performance as closely as possible. The gross yield is cow estimated at 2. They also have long experience of fund management mNorth America. You can buy units by completing the application form and sending it with your cheque for the arnountyou wish to Invest. You will be allocated units at the price ruling when, your application is received. We will send you a contract note within a few days tellirfcyoa the number and price of units allocated. You can normally expect to receive the certificate -within a month of purchase. First distribution will be on 30tfa April Vfi9. Units may be bought and 3 nld at the prevailing oBer and bid prices, and yield, which are published daily in leading nev. The offer price of units iroimjff. To seQ your units, simply return your certificate endorsed on the bar k. You will n? The management company is Craigmount Unit Trust Managers. The Bank of Scotland, The Mound. Edinburgh is the Trustee. Registered office: A number of those shares - AMI and whose owner is unknown. Then future date to be agreed. Do the documents which you might not have involved go to a central office? What would redemption — an application for happen If the local authority a search of the tithe map might compulsorily purchased yield a past owner's naxue. I have a right of way over my neighbour's land. Surmics MriMrsCvIbo. I jnvweare o' , or IS. Is there any yardstick for h, k h ,. The mortgagor bor- cent and 99 per cent based on rower should retain only a rateable values. The landlords copy of the mortgage deed. What can one do please? Y ' T There is no such yardstick as. Self- thmk that your points fa help mav prove a false economy. The local ' No fejol aiso be lodged with you or your it as an obstruction to your by position; techhicaliy to pursue agent. The mortgagor bor- right of way. There is however? Independent attitudes survive ;: IN5sO arise. The landlords have no catioa is still flourishing having power to prevent the tenants survived more or Jess intact the forming an association. But very 5. Howard,' ft. These limited results flated from the effect of the over Not unexpectedly, die. ORS groups made use of -the indepen- dent sector for the education of their children. Last week, lead- ing school fee specialists C farms. This means that both preference shares and Government securities are attractive investments for two important reasons. We have therefore uncovered Triparanol as potential new cancer therapeutic in treating multiple types of human cancers with deregulated Hedgehog signaling. Numerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known. To identify genes controlling glioma invasion, we used genome-wide mRNA expression profiles of primary human glioblastomas to develop an expression-based rank ordering of 30 transcription factors that have previously been implicated in the regulation of invasion and metastasis in cancer. SNAI2 mRNA expression correlated with histologic grade and invasive phenotype in primary human glioma specimens, and was induced by EGF receptor activation in human glioblastoma cells. Surface-bounded growth modeling applied to human mandibles. This thesis presents mathematical and computational techniques for three dimensional growth modeling applied to human mandibles. The longitudinal shape changes make the mandible a complex bone. The teeth erupt and the condylar processes change direction, from pointing predominantly backward A local shape feature called crest line has shown itself to be structurally stable on mandibles. Registration of crest lines from different mandibles results in a sparse deformation field, which must be interpolated When using successively more recent scans as basis for the model the error drops to 2. Thus, it seems reasonable to assume that the mandibular growth is linear Human pituitary and placental hormones control human insulin-like growth factor II secretion in human granulosa cells. Human granulosa cells cultured with calf serum actively proliferated for generations and secreted progesterone into the medium; progesterone levels appeared to decline with increase in generation number. The progesterone secretion was enhanced by the addition of human follitropin, lutropin, and chorionic gonadotropin but not by growth hormone. These cells, when challenged to varying concentrations of human growth hormone, human chorionic somatomammotropin, human prolactin, chorionic gonadotropin, follitropin, and lutropin, secreted IGF-II into the medium as measured by specific IGF-II RIA. Among these human hormones, chorionic gonadotropin, follitropin, and lutropin were most effective in inducing IGF-II secretion from these cells. The results described suggest that cultured human granulosa cells can proliferate and actively secrete progesterone and IGF-II into the medium. IGF-II production in human granulosa cells was influenced by a multi-hormonal complex including human growth hormone, human chorionic somatomammotropin, and prolactin. Purification of human platelet-derived growth factor. The paper describes a method for purification of human platelet-derived growth factor PDGF from outdated platelet-rich plasma PRP using commonly available laboratory reagents and yielding a mitogen purified ,fold over the starting material. Other assays to quantitate PDGF include radioreceptor assay and radioimmunoassay. Gold thread implantation promotes hair growth in human and mice. Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When embedded into the depilated Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Objective Dysregulation of WNT signaling plays a central role in tumor cell growth and progression. Design Prospective study of human leiomyoma cells obtained from myomectomy or hysterectomy. Setting University research laboratory. Our findings provide rationale for further preclinical and clinical evaluation of ICAT, niclosamide, and XAV as candidate anti-tumor agents for uterine leiomyoma. AMPK regulation of the growth of cultured human keratinocytes. Saha, Asish K. In the present study, we examined the relationship between AMPK activation and the growth proliferation of cultured human keratinocytes and assessed whether the inhibition of keratinocyte growth by vitamin D involves AMPK activation. In addition, we explored whether the inhibition of keratinocyte proliferation as they approach confluence could be AMPK-related. Like most cells, the growth of keratinocytes diminished as they approached confluence. Both showed nitrogen retention on balance studies, the older second patient to a marked degree. In the younger patient, height increased from The rate of growth approximately doubled during the first two treatment periods as compared with the pre-treatment rate. In the second older patient hgh was administered 5 mg daily intramuscularly for 21 out of 33 months. Growth from This increased growth rate occurred during the post-puberty deceleration phase. Transient adolescent gynecomastia appeared in Case 2. No local or general toxic effects were noted. These results are suggestive, but whether or not the eventual height of an achondroplastic dwarf can be significantly altered must await further studies. ImagesFigure 1. Figure 2. Selection and characterization of a human neutralizing antibody to human fibroblast growth factor Compelling evidences suggest that fibroblast growth factor-2 FGF-2 plays important roles in tumor growth , angiogenesis and metastasis. Molecules blocking the FGF-2 signaling have been proposed as anticancer agents. Through screening of a human scFv phage display library, we have isolated several human single-chain Fv fragments scFvs that bind to human FGF After expression and purification in bacteria, one scFv, named 1A2, binds to FGF-2 with a high affinity and specificity, and completes with FGF-2 binding to its receptor. In a set of vitro assays, it inhibited various biological activities of FGF-2 such as the proliferation, migration and tube formation of human umbilical vein endothelial cells. More importantly, hIgGA2 antibody also efficiently blocked the growth while inducing apoptosis of glioma cells. For the first time, we generated a human anti-FGF-2 antibody with proven in vitro anti-tumor activity. It may therefore present a new therapeutic candidate for the treatment of cancers that are dependent on FGF-2 signaling for growth and survival. Epidermal growth factor receptor in primary human lung cancer. Cell membranes were prepared from 12 human lung cancers for the study of the expression of epidermal growth factor receptors EGFR. The dissociation constants of the high affinity sites were identical, 1. These results suggest that EGF and its receptor may play a role in the regulatory mechanisms in the control of lung cellular growth and tumor promotion. A Big Bang model of human colorectal tumor growth. What happens in early, still undetectable human malignancies is unknown because direct observations are impractical. Here we present and validate a 'Big Bang' model, whereby tumors grow predominantly as a single expansion producing numerous intermixed subclones that are not subject to stringent selection and where both public clonal and most detectable private subclonal alterations arise early during growth. Genomic profiling of individual glands from 15 colorectal tumors showed an absence of selective sweeps, uniformly high intratumoral heterogeneity ITH and subclone mixing in distant regions, as postulated by our model. We also verified the prediction that most detectable ITH originates from early private alterations and not from later clonal expansions, thus exposing the profile of the primordial tumor. Moreover, some tumors appear 'born to be bad', with subclone mixing indicative of early malignant potential. This new model provides a quantitative framework to interpret tumor growth dynamics and the origins of ITH, with important clinical implications. The liver taxis of receptor mediated lactosaminated human growth hormone. Radiography imaging is used to assess liver taxis mechanism of anti-dwarfism drug lactosaminated human growth hormone L-rhGH. Both L-rhGH and rhGH labelled with I are used to study their biodistribution in animals including rabbits, cocks and rats. The results show that L-rhGH is of specific hepatic targeting property, and the maximum hepatic concentration rate is Its hepatic binding is receptor mediated. Expression of epidermal growth factor receptors in human endometrial carcinoma. Little data exist on the expression of epidermal growth factor receptors EGF-Rs in human endometrial cancer. EGF-R was identified on frozen tissue sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the external domain of the EGF-R. Seventy-one percent of the carcinomas expressed positive EGF-R immunoreactivity. In general, staining was most prominent Radioimmunological activity of 22K variant of human growth hormone. From a preparation of human growth hormone its integral variant hGHK was isolated by isoelectric focusing, having a pI of 5,20 and relative mobility Rm of 0, in the polyacrylamide gel electrophoresis. Several experiments for the characterization of the isolated variant were carried out. The immunological properties was tested by radioimmunoassay RIE , in which the activity of the isolated variant and the activity of the total preparation were compared. The dose response-curves obtained by RIE were found to be considered parallels p [pt. To determine the rate of growth of these colonies, recipes were developed using CL-Quant software which enables users to extract various types of data from video images. To accurately evaluate colony growth , three recipes were created. The first segmented the image into the colony and background, the second enhanced the image to define colonies throughout the video sequence accurately, and the third measured the number of pixels in the colony over time. The three recipes were run in sequence on video data collected in a BioStation CT to analyze the rate of growth of individual hESC colonies over 48 hours. To verify the truthfulness of the CL-Quant recipes, the same data were analyzed manually using Adobe Photoshop software. When the data obtained using the CL-Quant recipes and Photoshop were compared, results were virtually identical, indicating the CL-Quant recipes were truthful. The method described here could be applied to any video data to measure growth rates of hESC or other cells that grow in colonies. Short-term effects of recombinant human growth hormone and feeding on gluconeogenesis in humans. After a short-term fast, lactating women have increased rates of glucose production but not gluconeogenesis GNG despite relative hypoinsulinemia. We explored the effects of non-insulin-dependent increase in glucose utilization and recombinant human growth hormone rhGH on glucose production, glyc Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone. The growth hormone GH -deficient dwarf rat was used to investigate recombinant human rh GH-induced bone formation and to determine whether rhGH facilitates simultaneous increases in bone formation and bone maturation during rapid growth. The GH group received 1. Biochemical, morphological, and X-ray diffraction measurements were performed on the femur middiaphysis. Adaptation to statins restricts human tumour growth in Nude mice. Statins have long been used as anti-hypercholesterolemia drugs, but numerous lines of evidence suggest that they may also bear anti-tumour potential. We have recently demonstrated that it was possible to isolate cancer cells adapted to growth in the continuous presence of lovastatin. These cells grew more slowly than the statin-sensitive cells of origin. In the present study, we compared the ability of both statin-sensitive and statin-resistant cells to give rise to tumours in Nude mice. HGT-1 human gastric cancer cells and L50 statin-resistant derivatives were injected subcutaneously into Nude mice and tumour growth was recorded. At the end of the experiment, tumours were recovered and marker proteins were analyzed by western blotting, RT-PCR and immunohistochemistry. L50 tumours grew more slowly, showed a strong decrease in cyclin B1, over-expressed collagen IV, and had reduced laminin , VEGF and CD34 levels, which, collectively, may have restricted cell division, cell adhesion and neoangiogenesis. Taken together, these results showed that statin-resistant cells developed into smaller tumours than statin-sensitive cells. This may be reflective of the cancer restricting activity of statins in humans , as suggested from several retrospective studies with subjects undergoing statin therapy for several years. Homologous radioimmunoassay for human epidermal growth factor urogastrone. Epidermal growth factor EGF , a polypeptide hormone originally discovered in the mouse submaxillary gland, stimulates growth in a variety of tissues in several species. This hormone has recently been identified in human urine. In general, levels were similar to those recently reported using a heterologous RIA system. Excretion by females taking oral contraceptives was significantly greater Several of those with very low values had histories of alcohol abuse. Excretion by patients with Cushing's syndrome was normal. Patients with psoriasis or recovering from major burns excreted both abnormally high and abnormally low levels of RIA-hEGF, with no obvious correlation to their clinical condition. And, hair re- growth promotion in the gold threadimplanted mice were significantly higher than that in PGA thread group on day 11 after depilation. In particular, the skin tissue of gold thread-implanted mice showed stronger PCNA staining and higher collagen density compared with control mice. Effect of temperature on the radioiodination of human growth hormone. Studies have been undertaken to assess the effect of altering the temperature at which human growth hormone is radioiodinated on the incorporation of I and the immunoreactivity and stability of the labelled hormone. Employing highly purified monomeric hormone it proved possible, by the iodogen procedure, to prepare a labelled product of high specific activity irrespective of temperature. However, in radioiodinations performed at ambient temperature 20 to 25 degrees significant amounts of the labelled hormone were in an aggregated form which was less immunoreactive than the I-labelled monomeric hormone. From a set of 31 three-dimensional CT scans we model the temporal shape and size of the human mandible. Each anatomical structure is represented using semi-landmarks, and mapped into Procrustes tangent space. Exploratory subspace analyses are performed leading to linear models of mandible The traditional variance analysis results in a one-dimensional growth model. However, working in a non-Euclidean metric results in a multimodal model with uncorrelated modes of biological variation. The applied non-Euclidean metric is governed by the correlation The generative models are compared, and evaluated on the basis of a cross validation study. The new non-Euclidean analysis is completely data driven. It not only gives comparable results w. IL-8 had no effect. Epidermal growth factor and its receptors in human pancreatic carcinoma. The role of epidermal growth factor EGF in oncogenesis and progression of malignant tumors is a subject of vast interest. In this study, radioimmunoassay and radioreceptor assay of EGF were established. EGF contents in malignant and benign pancreatic tumors, in normal pancreas tissue, and in culture media of a human pancreatic carcinoma cell line were determined. EGF receptor binding studies were performed. It was shown that EGF contents in pancreatic carcinomas were significantly higher than those in normal pancreas or benign pancreatic tumors. EGF was also detected in the culture medium of a pancreatic carcinoma cell line. The binding of I-EGF to the pancreatic carcinoma cells was time and temperature dependent, reversible, competitive, and specific. Scatchard analysis showed that the dissociation constant of EGF receptor was 2. Human milk fortification strategies for improved in-hospital growth of Human milk is the preferred feed for preterm infants, yet it may need to be fortified for optimal growth and development. Standard fortification of human milk seldom meets the recommended intake of protein, leading to inadequate post-natal growth. This article aims to critically review different human milk fortification Developmental regulation of human truncated nerve growth factor receptor. DiStefano, P. Urine samples were collected from 70 neurologically normal subjects ranging in age from 1 month to 68 years. By using this sensitive two-site radiometric immunosorbent assay, NGF-Rt levels were found to be highest in urine from 1-month old subjects. No evidence for diurnal variation of adult NGF-Rt was apparent. Pregnant women in their third trimester showed significantly elevated urine NGF-Rt values compared with age-matched normals. These data show that NGF-Rt is developmentally regulated in human urine, and are discussed in relation to the development and maturation of the peripheral nervous system. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Human papilloma virus HPV types 16 and 18 are most commonly associated with cervical carcinoma in patients and induce immortalization of human keratinocytes in culture. HPV has not been associated with breast cancer. This report describes the immortalization of normal human mammary epithelial cells 76N by plasmid pHPV18 or pHPV16, each containing the linearized viral genome. Transfectants were grown continuously for more than 60 passages, whereas 76N cells senesce after passages. The transfectants also differ from 76N cells in cloning in a completely defined medium called D2 and growing a minimally supplemented defined medium D3 containing epidermal growth factor. HPV transfectants do not form tumors in a nude mouse assay. It is concluded that products of the HPV genome induce immortalization of human breast epithelial cells and reduce their growth factor requirements. This result raises the possibility that HPV might be involved in breast cancer. Furthermore, other tissue-specific primary epithelial cells that are presently difficult to grown and investigate may also be immortalized by HPV. Expression of the human growth hormone variant gene in cultured fibroblasts and transgenic mice. The nucleotide sequence of the human growth hormone variant gene, one of the five members of the growth hormone gene family, predicts that it encodes a growth hormone-like protein. The growth hormone variant protein expressed in transiently transfected L cells is distinct from growth hormone itself with respect to reactivity with anti- growth hormone monoclonal antibodies, behavior during column chromatography, and isoelectric point. Transgenic mice expressing the growth hormone variant protein are 1. Algorithmic complexity of growth hormone release in humans. Most hormones are secreted in an pulsatile rather than in a constant manner. This temporal pattern of pulsatile hormone release plays an important role in the regulation of cellular function and structure. In healthy humans growth hormone GH secretion is characterized by distinct pulses whereas patients bearing a GH producing tumor accompanied with excessive secretion acromegaly exhibit a highly irregular pattern of GH release. It has been hypothesized that this highly disorderly pattern of GH release in acromegaly arises from random events in the GH-producing tumor under decreased normal control of GH secretion. Using a context-free grammar complexity measure algorithmic complexity in conjunction with random surrogate data sets we demonstrate that the temporal pattern of GH release in acromegaly is not significantly different from a variety of stochastic processes. In contrast, normal subjects clearly exhibit deterministic structure in their temporal patterns of GH secretion. Our results support the hypothesis that GH release in acromegaly is due to random events in the GH-producing tumorous cells which might become independent from hypothalamic regulation. Clinical impact of biotechnology has been constrained by the limitations of traditional hypodermic injection of biopharmaceuticals. Microneedle patches have been proposed as a minimally invasive alternative. In this study, we assess the translation of a dissolving microneedle patch designed for simple, painless self-administration of biopharmacetucials that generates no sharp biohazardous waste. After manual insertion into the skin of hairless rats, hGH pharmacokinetics were similar to conventional subcutaneous injection. After patch removal, the microneedles had almost completely dissolved, leaving behind only blunt stubs. The dissolving microneedle patch was well tolerated, causing only slight, transient erythema. This study suggests that a dissolving microneedle patch can deliver hGH and other biopharmaceuticals in a manner suitable for self-administration without sharp biohazardous waste. Humanized versus murine anti- human epidermal growth factor receptor monoclonal antibodies for immunoscintigraphic studies. Morales, Alejo A. The mAb ior C5 that recognizes an antigen expressed preferentially on the surface of malignant and cytoplasm of normal colorectal cells was used as negative control. Among all organs significant accumulation was found in tumor 6. The immunoreactive fractions were found to be 0. Thus, we expect better results using the humanized mAb h-R3 for diagnostic immunoscintigraphy. The anti- human epidermal growth factor receptor EGF-R humanized antibody h-R3 IgG 1 , which binds to an extracellular domain of EGF-R, was used to evaluate the biodistribution on nude mice xenografted with A epidermoid carcinoma cell line. Immunoreactivity of 99m Tc-labeled mAbs was measured by enzyme linked immunosorbent assay on A cell line and the immunoreactive fractions determined by Lindmo method. Full Text Available In order to address the direction of causality between human capital and productivity growth in Nigeria, the study first investigated the pattern of productivity growth in Nigeria between and Following the endogenous growth model, which argued that technical progress, through an effective labor force, could lead to long-run growth which can be determined from within an economy; but it actually depends on the efficiency with which resources available to such an economy are utilized. This is against the exogenous growth model which emphasized that long-run growth can be attained by some unexplained technological progress, which is exogenous to any economy. Based on this controversy in literature, this study empirically determined the productivity growth in Nigeria, as well as the causal relation between human capital development and productivity growth in Nigeria using the Engle-Granger causality test. The results revealed that productivity growth has been very low and unstable in Nigeria as it oscillated between In addition, the nexus between human capital and productivity growth was examined. The findings revealed that while productivity growth caused human capital development, human capital development did not cause productivity growth. Metabolic clearance and production rates of human growth hormone. No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's. 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So loss elimination should be worth Elsewhere Rin aoki porn etotic clips milling division did better, and grocery products and meat are singled out as having done well. The one question for the market is haw quickly Spillers will restore its dividead.

Last year Rin aoki porn etotic clips profits collapsed the dividend was slashed from 2. The market is banking on Spillers going some way to restoring the divi- dend this year. For the whole of last year losses in the U. This left group profits only. The problems seem to have been click.

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First, Mothercare j set up its U. The bulk of these were under 1. Secondly, the Mothercare management in the U. Strenuous efforts, Rin aoki porn etotic clips top management Rin aoki porn etotic clips, are now going Rin aoki porn etotic clips to turn the pro- ject round. And meanwhile the stores operating under the Mothercare name are apparently doing well.

Impressive though ' the Dow's losses have been Rin aoki porn etotic clips the last two weeks, they in fact understate the broad market decline, notably the routing of secondary stocks. The American Stock Exchange which hosts many' of the smaller, less capitalised companies, has seen its index tumble by a formidable 17 per cent front its peak in mid- September, while the Dow has suffered a more modest 9. On Thursday the Dow drew back by 9. But yesterday the decline quickened and the Dow dropped Technical analysts looking for a rainbow claim they are only mildly surprised at the slaughter.

They point out that before the rally which started last April the market bad been seriously weakened by the Blue Chips — the IB Ms and Polaroid; of this world — while the smaller stocks had shown positive strength for most of last year. Meanwhile, away from the technicians' charts investors have found that the world is too much with them. In a brief but grisly recap the week's news has included a rise in commercial hanking prime rates to per cent, the.

A 19th-century Russian novelist would have been strained to write a more depressing scenario There is as much scepticism in the U. Somewhat curiously there has been no attempt berc to cite the achievements of Britain's voluntary policy in justification for the new approach when Rin aoki porn etotic clips the surface Rin aoki porn etotic clips prospects for success are at least as good as they were in Britain.

When they have been at their most negative they have simply assumed that conditions have been so bad. Perhaps the time has come again to search Rin aoki porn etotic clips a new meta- phor. The latest batch of quarterly results from North American groups show- a dis- tinct improvement over a year ago, if not in profits at least in sales. It is tempting to see the figures as the definite start nf a new trend, but the U. Another of the U. It came back into Ihe black in the second quarter and in the three months to No.

The said Minute is in Rin aoki porn etotic clips wordsand figures following: Charles Barber, the Asarco chairman. Tm iD the same three mouths of Although zinc prices hafe been at lower levels than last year, lead demand has been strong and looks like remaining so.

Further evidence nf the revival in the copper industry came from Freeport Minerals, whose profits in the September quarter jumped sharply to S7. In contrast the market for tin has been consistently strong. But this bas not provoked any consistent rise in Malaysian production, as the accamsnyiaz fable shows.

A combination of higher taxes Rin aoki porn etotic clips. Sprinkel publicly to disclose his intention of try- click to see more to put together a financial package allowing him to take- over the Wheal Jane tin mine in Cornwall. Sprinkel is an American entrepreneur, now resident in Derbyshire, and within the next two weeks he hopes to make Consolidated Gold Fields, the present owners, a definite offer.

Ayer Hitam - Be r junta! Piran — Far East St. Piran— UK South Crafty Southern Malayan Tanjong Tong kah Harbour 42 40 Tronoh i Figures hi elude low-grade material f Not yet a puts are shown in metric tonnes of tin concentrates.

Sept, Atut. Another metal which has strengthened its price despite the recession is molybdenum. A in ax. This level was reached four months before bullion peaked ar SI Political factors arc one reason for the poor general per- formance of golds. A good ex- ample of the short-term effects arose last week, during the visit of the five western foreign ministers to Pretoria. On tiie Wednesday, the gold price hit a new record las it then was of S Politics, however.

Mine violence has died down, the mine- have obtained a better spread of labour, which five years ago ua. One overriding reason for the low level of interest in golds is ihe growth of ihe gold furures markets in the U. In these markets did not exist and physical gold ownership was only authorised early in So gold shares Rin aoki porn etotic clips U. Wnn trading in the U. This aside. The table shows U. The top 15 account Rin aoki porn etotic clips R5.

However, the table shows the U. In addition to U. There has also been a massive flow of De Beers shares to the U. Johannesburg brokers estimate 10 per cent of De Beers is now held in the U. Except to the U. With the local institutions traditionally more interested in industrials than golds and the European investor virtually out nf the market for a mixture of political and financial.

Rin aoki porn etotic clips the counter- pull of the future markets and the high existing level of U. Gcfinlrl 45 Western Holds. Brand Rin aoki porn etotic clips 66 Pres. Totals 5, Tx Gar t m ore Fmxl Managers Lid. Eamonn Fingleton iks at ways to cut the cost. But unless you are care- you will lose about T per of your capital in dealing ; every time you switch, point is thai the Rin aoki porn etotic clips of a switch is often the difference between the r" price at which unit: He needs to choose a?

Jives tors who get into units. These can he useful when the outlook for shares turns choppy. With some groups— Hambro. First switch free. Cutting the bother of Child Benefits ing in various types of equities Some unscrupulous brokers for bond investors.

Barclays have been click the following article recently for Unicorn bondholders cannot drumming Blonde milf properly fucked by bbc commission by link their investment to any encouraging unnecessary switch- particular unit trust but instead ing.

Such brokers are unlikely it is put in a managed fund invested in a selection of the group's trusts.

Rin aoki porn etotic clips managers vary the mix as market conditions dictate. Barclays, for instance, usually deducts in Rin aoki porn etotic clips the amount of any commis- for cent initial commission introducing new business. Indications for the second and third weeks arc that sales are lower, bill still very strong. The sudden sales surge re- flects the fact that -from October 1. Yet this jump in sales no- where near represents the full potential that could have taken place.

There are about lira persons holding these certifi- cates, of whom over lm held the maximum holding before October 1. Looking to the immediate future' and the likely movement in the Retail Rin aoki porn etotic clips Index, the official forecasts are that the year-on-year increase will re- main around S per cent for the next six months.

But unofficial forecasts of r the rise of the RPI in the next 12 months vary from 6 to 12 per cent depending on the view Rin aoki porn etotic clips forthcoming wase settlements. Stockbrokers Phillips anti Drew, for example, is forecasting an They have lo watch patiently as the assistant goes through the palaver of stamping the benefit book, removing a counterfoil and counting our the money. The procedures are more appropriate in the days of Rin aoki porn etotic clips Penny Black than to an institu- tion that is now loading the world in such high-tech oology fields as Viewdata.

From the outside, one would have though! And for working mothers in particular — who are more likely than stay-at-home wives Rin aoki porn etotic clips have their own bank accounts — the freedom from The need to traipse regularly to the Post Office would be a major boon. The Department of Social Security secs immense obstacles but it admitted Rin aoki porn etotic clips week that it Rin aoki porn etotic clips at least begun to study seriously the possibility of pay- ing the benefits by credit trans- fer where a mother so desiTes.

The officials are also looking at the question of paying the Old Age Pension by credit trans- fer. The proportion of pen- sioners who bave bank accounts is lower than for the active population: No figures are available but the Department seems to fear that the savings to it later on would not com- pensate for the extra expenses early on.

Two payment systems would involve a great deal of duplication of effort, the Depart- ment adds. But it is not as if the sums the Department is paying nui are small: The Depart- ment is pressing ahead with cninnilinc a report for ministers. But such a dogmatic view- point Rin aoki porn etotic clips to assume that husbands and wives are con- stantly bickering over ihe house- keeping money.

Any wife who is happy about the way the family's finances are shared out and does not agree that this view is typical will feel insulted that the Slate does nut allow her to make up her own mind on whether ihe money should be paid into a joint account Bankers feel that there may be one other reason why Social Security officials may be luke- warm about introducing credit transfers: But the cost of disposing of cash is a small price to Rin aoki porn etotic clips for the extra convenience for mother and pensioners.

The objective of the Allied Hambro Pacific Fund is to obtain long term capital growth by investing: It enables you to invest in Singapore, Malaysia and the Philippines Ji a ve offered considerable potential for economic growth. Now a number of countries in this area huve begun to achieve their potential, and in recent years have shown remarkable growth rates, often twice that of many major industrialised countries.

Until a few years ago political instability in the area was a major deterrent to investment. But while there is some risk of recurring political disturbances, the political climate, particularly following China's policy of improving relations with its neighbours, now appears more go here. At the same time, there is now within this area a.

Oriom Ovmm Couninm Svtiru Pacdtr 1-ld. Swim TropotOoi Lid. V Wimor Industrial Corn. Malayan Banking fifed. The objective is to maximise long-term capital growth; income is not a consideration. The improving prospects of the area have already been reflected in rising stock market values during this year.

While we consider that the prospects for growth will continue, you should bear in mind tbat investment in these markets con be subject to substantial short-term fluctuations.

We recommend therefore that an investment in the fund should form only part of a balanced portfolio. That having been said, the advantages of investing in South East Asian marked through an authorised unit trust are powerful indeed, in terms of simplicity, convenience and spread of risk. An investment in the fund should be regarded as a long-term one.

Remember the price of Rin aoki porn etotic clips and the income from them may go down as well as up. You should also note that currency movements can significantly affect the value of your investment. How to invest Investment opportunity To take advantage of opportunities to invest in companies operating in this area of potential growth, and to avoid the pitfalls, the experience of full-time. The portfolio 'is currently heing invested in the shares of companies quoted or operating in Hong Kong.

Singapore, Malaysia go here the Philippines, including companies registered in London or elsewhere which. You will be allocated units to the full value of your remittance at the offer price ruling on receipt of your application. Units in the fund may also he acquired on a Tegular monthly basis.

For further details complete and return the coupon below, ticking the appropriate box. Uni La may normally be bought and nofel on any Lw mrUnK to. SeUlnff units. RtcUMit oAn u. I wish to invest Sifegiunlf. Thr Trvrtoe u! Chorees- The offer nricr cvmnll.

The charge is currently lS. Xtuun appltatlicBi is granted, umtholden fat the bail Rin aoki porn etotic clips be asked to approve the anffopnatemerease. J declare that I am over 18 sod am not resident outside the UK or other Scheduled Tern tones and that I am not acouinna die above units Rin aoki porn etotic clips the.

If you ere unable to malic ihe residential declaration it should be deleted and Rin aoki porn etotic clips form lodged through your UK bank, stockbroker or solicitor. This Offer is not available to residents of the Republic of Ireland. The Director nf Fair Trading. Gordon Borrie. It is also satisfied with the Rin aoki porn etotic clips regulations for the control of insurance brokers. Here it feels that There is room for chanses to avoid the quick kill type of sales, by spreading the initial commission over.

The Department of Trade has been pursuing this same line with the LOA, which up tu nuw has adupted an air that all is well.

The OFT states quite categorically that front rhe complaints it receives all is not well. But one word of advice to Rin aoki porn etotic clips OFT. The results were alarming. Ourresearch shows clearly that you want your capital to grow, with a minimum of tax liability. You want to be able to get atyour money fast whenever you need iLFrequently, you Rin aoki porn etotic clips want a regular income from it- taxfree.

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The balance of this investment mix is altered continuously to Rin aoki porn etotic clips changing market conditions and opportunities. This is how yourinvestment receives the same quality of investment service provided to those with millions of pounds. We pay the postage. Your money will then buy units in the Managed Fund at the offer price ruling on the day we receive your cheque and we will send you your Bond document showing the exact number of units in your Bond 1 To: London WBR.

Are you in good physical Rin aoki porn etotic clips mental health and free from the effects of any previous illness or accident? If not please give details. Hf Registered No. Birmingham, has been so r great. And especially so if he was interested in a Ford. The panel of: When they did their rounds on Press day. This year's entries were from Western Europe. Soon 1BC. U1 — some may think belatedly — will consider wheilier or not to open the contest a: There arc live categories for cars— saloons, estates, hatch- Source CASS backs- limousines and sports models — plus a couple for motor caravans and one for special bodywork.

Other categories which hardly concern the motorist are for vehicles ranging from mini-buses to tractor cabs, juggernaut trailers to double-deckers.

As a motoring correspondent, my judgment of a car has always been based more on the way it goes than the way it looks. Sorting out the cars most deserving of gold and silver awards from exhibits standing still or at most re- volving on turntables demanded new criteria. Judging a car objectively when it t; out of its element is curiously difficult. Taking account of general exterior and interior design and finish is fairly straightforward. But general visibility, accessibility oi controls and, above all, com- fort.

These relate more realistically to a car in motion, run at rest. For example, a driving seat that may look mag- nificently comfortable in the snow. That I know from experience. Might it not also be risky to award mark? My job.

After hours of i. Vauxhali Rin aoki porn etotic clips and Rover I am Rin aoki porn etotic clips wondering why the Rover was not classified as a hatchback.

Why the Renault 18 and Royale for golds? The Renault scored above-average for every- thing except visibility. It looked elegant on the stand, with a faultlessly colour matched interior, one-piece moulded headlining aud a flat-floored boot uncluttered by the spare wheel.

That lives underneath in a cradle and can be wound dawn by the jack handle with- out disturbing the luggage. Badges apart, the Royale is an Opel Senator, though with less power and a lower price.

It looks in every way an urbane carriage for the top executive.: Of the runners-up. The Vauxhali Carlton offers many Rin aoki porn etotic clips the facilities of the Royale at half he price. And the Rover gained marks lor its colossal luggage accom- modation and convenient lifting tail hut lost some for poor rear- ward visibility and. Does anyone else share our feeling that this otherwise admirable motor https://husband.revia2018.host/page5877-hilu.php would be improved by a higher roofline and deeper windows?

In Seve Ballesteros. Nick Here, Rin aoki porn etotic clips Brown. Howard Clark, and Mark Janies a poten- tially brilliant nucleus for Rin aoki porn etotic clips Ryder Cup teams has emerged — and Rin aoki porn etotic clips a moment too soon.

One can only hope that when Europeans are allowed to play for our team next Septem- ber for the first time at The Greenbrier, White Sulphur Springs. West Virginia, a resort complex course recently re- designed by Jack Nicklaus. But a spy. Andrews by the most heart-warming ovation any golfer could wish to receive. This was the best moment of the year for me. This latter event is definitely the high-spot of the golf spectator's year. Nothing could better emphasise the gulf that exists between the American and the European tours than the fact that Hayes immediately won both the Italian and French Open titles.

Before Hayes, it had been Clark who had dominated the Iberian peninsula. Having won the Portuguese Open from Brian Barnes on a Penina course that had previously des- troyed him. But Clark's, victory in Rin aoki porn etotic clips was the most satisfying, in that he left Jose Maria Canizares Rin aoki porn etotic clips whose 9 holes in 27 shots during the Swiss Open was possibly the greatest achievement of the season — and Ballesteros in his wake.

But the latter Spanish prodig ' brought -the golf world to his feet by winning at Greensboro. North Carolina — a fantastic performance, since he was 10 shots behind the leaders, with 36 to play. Ballesteros's really golden period, however, followed bis miserable failure at St. When Seve won the German. Club pro- fessional Brian Waites of Notts. Outstanding In the amateur ranks. Peter aJcGvoy was outstanding as a rare successful defending British champion.

He per- formed with distinction in the U. Ohio, in the World Series Rin aoki porn etotic clips Golf. But by the time he got to Pacific Harbour. Fiji, for the Eisenhower Trophy, he had gone off the boil.

British were made Rin aoki porn etotic clips look- sorry, chiefly because the outstanding American ' amateur of this and many former years. Bobby Clampett. I am grateful and feel that the time has not been wasted.

X hope that these two hands, which occurred last week, will appeal to you. Here is the first: East came in with two hearts. West led the three of hearts, taken by the Ace, and East returned the nine of diamonds. After some thought I let this run. If the finesse was wrong. I had a loser in each Rin aoki porn etotic clips, and my only hope of getting home appeared to be an endplay.

I dismissed the possibility of a diamond ruff. I had to assume that East had at least two cards in the suit— if she had a Rin aoki porn etotic clips ton. Rin aoki porn etotic clips was not going to make the contract anyhqw. West won with the King, returning the'two— I -was thank- ful to see East following suit — and I won in hand. When East dropped the Queen, it looked as if her hand pattern was S- 6 click the following article 2 - 2.

I made my other two j diamonds, on which East dis- carded two. East was securely endplayed, and her forced heart return gave me the ruff discard for which I had planned, allowing me to dispose of my losing dub while dummy ruffed. The second hand was far simpler, but it has more than one point of interest: West overcalled with two diamonds — now that is a bid with which one might Rin aoki porn etotic clips fault— and my partner doubled for penalties.

This, of course. When West led the heart ten, I wan on the table, cashed the spade Ace, and returned the six of diamonds. East played low, and the nine won. Now West, who had found the best lead, instead of continuing with his other heart— his partner had dropped the eight at trick one — made the senseless return of a low diamond, which at pairs would have been disastrous. Ruffing in hand. Ten tricks were now certain, but I led ' the club five and finessed dummy's nine.

Rin aoki porn etotic clips won with the King and led the Queen of hearts— too late. I won with the Ace. I did not care which defender had the Queen of clubs.

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The second hand was far simpler, but it has more than one point of interest: West overcalled with two diamonds — now that is a bid with which one might find fault— and my partner doubled for penalties. This, of course. When West led the heart ten, I wan on the table, cashed the spade Ace, and returned the six of diamonds. East played low, and the nine won. Now West, who had found the best lead, instead of continuing with his other heart— his partner had dropped the eight at trick one — made the senseless return of a low diamond, which at pairs would have been disastrous. Ruffing in hand. Ten tricks were now certain, but I led ' the club five and finessed dummy's nine. East won with the King and led the Queen of hearts— too late. I won with the Ace. I did not care which defender had the Queen of clubs. Special Show offer: I only. Tahiti blue, tarcan red. Contact Mr. If you havs a fine classic or collectors car allow us to show it to over 2, prospective purchasers and realise its full value. Over cars expected, these will include: Be sure to request your entry form today, victoria and Co. Telex 8S Demonstrators available. Always 20 guaranteed used models in stock. White; L. Thuraan Holland. Pirc Defence. Results were N-B3: Yugoslavia and o? H 4 PJW ivmes, in tnai year, are the material loss. Obly Fischer among f! For Miles. Spassky in his toe used. Moreover, if the challenger manages to achieve' all this and beat Karpov at the end of -It, there is still a return match clause IS months later. Ribli, IBM potential challenger k that. Umre Amsterdam Was it players who. Spassky— -when It would have been most Interest- ing. Chess Is virtually unique as a game where practically all the international play is th the form of tournaments but the world title is decided by 1 a match , at long intervals. Chess grand- masters are rarely -at their peak for more than a decade , and so the opportunities -are too few, it is really time the. Even if you cram loot with goodies like baked is. British ledonian will introduce cing s on its. Farewell to the ie-elevcns. While the Canaries in general Balearic; and. Mcon Villas a wide choice in 31al la. Paul's Bay. I adore the Algarve at any j, 5,-w. These all. Lan- Paphos, the port which dates and Exchange Travel explain in fater J? Special terms io companies. Details and ilhisl rated brochure or request Tel: Frcnthl hllchC' Bjr. Phone , 01 lB': J1 2a 'I Swimmlne pool. Caribbean Corny cti on. Parker Road. Kent TN14 70 B. Mask of. Magic of Sardinia Ltd.. MedoUfon- Holidays, Edgware Rood.. Loudon W2 2DS. Mcon Winter Holidays. OSfc House. Seietire has id.. Tinii,-d ih. Ho Long Months of Waiting. Remits brpln inimediaiely. Lift- DJuamirs ivrh nuiues oCcr sclf-masiery wuhoin sell- taenfife. Papers arc set for: Girls who will be under 32 years on 1st September. Girls who will be under 13 years on 1st September. Girls who will be under 14 years on 1st September, In addition, either one of two Music scholarships of the same value may be awarded annually to girls of any age. Miss V. All levrh. Leclere - Villefranche-uir-Mer - Tel: Part Ldnr. London W1 on Tuesday. To re. By Order cf the Board P F. Roe Secretary 27 October Notes Only members holding fully paid Ordinary shares, or their duly appointed rcDrcsentatim. A member so entitled may appoint a nrovr. EcaR sea -5 ffy. Other Euro- foreigner. On a good day in buyers are telling our nego- eussion recently about by how rate controversy. John's Wood. X may own a thriving The attraction still conunues waiting to buy. X may own a thriving The attraction still conanues waiting to buy. British Ley- because of other factors. The houses and flats to get the fteel slower rate of growth. Ready St John's Wood Hampstead and of selling blight. So in land and the coal miners strike, "invaders" were treated of the city and decide on the to move into properties are the surrounds mean nothin'- to prices leaped upwards surpass- the pound staggers, inflation is exactly as that. London was a best place to buy. Your local of a three day week looms. John's Wood or conductors excepted. His business is failing; the buyer changed all that. If Mr. Y Stores became multi-lingual, influenced the market. NWS 4 Beds. NW3 5 Wellington Ct. Stephens Cl. James 5q. Mawes have received Instructions to sell what must be one or the most distinctive properties In St. Mawes in south-west Cornwall. Known as Trewithit, it enjoys a superb situation with views across the Fal Estuary - to Pendennis Head. It has a ducted oil-fired central heating system. Toler- unsaleable. The explanation flowering carnations for ex- oeoo That was the situation, plants. A beV y of buyers chasing of virus infections. Inemi noiiori hv. It infects a great actual losses caused by vtruj it. It varieties as well as seeking? They systemic insecticides In fact, care to experiment carbendawm: And, of course, battle cry of the front line Great faith was placed on the one corollary of this was that vendors was "find me a rich meristem method of prnpaga- any treatment that merely Arab". This was an anomalv tion 3 fe w cells excised suppressed the symptoms with- in itself as the majority of over- from ll,e fast-growing tips of out eliminating the virus was seas buyers probabiy came sh? The old story of. Peterhead 8 miles Aberdeen 28 miles. Oil Central Heating. Planning permission applied for hotel and extension. G0 per acre In all about 5SS. Let on single Agricultural Tenancy dated February 1. On Wednesday, 22nd November, , at p. Subject m Reterwo. Liverpool 2. A M Cl Magnificent villa situated in its own beautiful seven acre grounds, superb views to Nice, Cannes and the Mediterranean. The house which will accommodate up to 20 people in great comfort, has 10 bedrooms. Two additional cottages in the grounds. The property is for sale with all its quality furnishing at a substantial price. For further details please apply: Thu is the ideal location for chose seeking die best of both worldi. Diane Steward Tel: Excellent swimming— warmest salt wacer. Formerly supported three farms. Chartered Land Agena. Lemon Villas. Truro Tel: South Coast and St. Viewi to the sea oeer otatefuf wooded parkland of S4 acres. Suitable far prime occupation, institutional use or conversion into fiats. Histone I4ch Century buildina at present subl-ng for conversion. Far required Tr crivaie l rr. The newly built: It has 2 conference rooms and a grill restaurant The hotel is centrally situated, but in a secluded spot The hotel is for sale and a quick settlement is wanted, Bergen has rich traditions in tourism and business travel. Would interested buyers please. Tgtotlan, IrtvesUnem areas. HIKpo Home. Honmd Lana. These are ideal for sending to rela- tions and friends at home and overseas, as well as for your own discerning enjoy- ment DEPT. Strum pihaw, Norwich Tel: Telex-- Hampers. Colour brochure on request public notices. Edlnbuntti EBiraR. They make marvellous presents.. Since I last wore about them they have added: I'm convinced, is an art and some penple arc much better at It than others. The old cliche about it being the thought and not the cost that really matters is. Even quite ordinary items like stationery, key-rings, cuff-links, can be transformed into something special if enough imagination and care has gone into choosing them. The one thing they all require is some advance planning. You really must order now if you want to he sure of them being ready for Christmas. You can send a photograph or the message to Sylvia's and they will be dealt with by mail of, alternatively they can be done while you wait. Some people ask for logos, letterheads, others like loving messages. They could be a good addition to a Christmas stocking. Cyril Came and Son, Wentworth Avenue, London N3 do several of the usual personalised items track-suits, towels etc but have recently introduced a nightdress rase which looks quite pretty. In red. Orders take about three weeks. Stephanie Roberts dues very beautiful batik w'ork on silk and can produce scarves that are very distinguished and very individual. She can make scarves of any and every colour except black and you can order them with a name in one corner or with the name used as the motif going right round the whole scarf. There are several sizes. The silk is very fine, the batik work exquisite and you can virtually ask for your own coiourways or design. The pies roust be large— 13 lb, b or 30 Jb. Orders will take about 10 days. Box 19, Swindon. If yon know a golf fanatic Kaleidoscope can also provide a pair of hallmarked sterling silver ball-markers engraved with up to four initials apiece. They are supplied fn a little leather carrying case. Portraits by Care! She loves working in quilted and padded satin which she often prints with her own rather special flowery designs. She has now devised a series of special white polyester satin hot waler-hottle covers and these can be ordered with any special Dame or theme in green, yellow, fuchsia, purple or blue. Special orders can be made to Fitzroy Frag the name of Rose Elliott's company. Box , 4 Reckitt Road, London W4. When ordering you should include your phone number as Rose Elliott may like to consult you about colours or 'other details. She will also send a list of different types of script, flowers or whatever else you would like included in the design. Orders should take up to three weeks. The bottle You must specify whether it is to be 11 ins. There is a choice of four different sorts of canvas 12 holes to the inch is the most popular. The Needle- woman Shop of Regent Street can give advice about choosing. It looks to me quite difficult to do in that although the full-colour photograph 'Is printed on to the canvas there are no absolute directions over which colours to put where and bringing human features to life is not easy. Needlecraft, 60, Holmes dale Road. Teddington, Middlesex. Delivery is about four weeks. Make sure that the print you send is clear; jf necessary cut out irrelevant details in the background. The designs are all, naturally enough, on racing themes, and I suppose on the assumption that racing circles are well-heeled, the prices are not low. V V ViT. MOST of us tend to think that commissioning portraits or sculptures is the province of the very rich or of grand com- panies which want to honour their distinguished presidents. Not many people realise that it is easier, less daunting and Jess expensive than they might imagine to have carried out either a portrait or a sculpture of either themselves or some- body they are fond of. The most reasonable method that I know of unless you have access to an Impecunious and talented future Augustus John is through two organisations that specialise in sifting both artists and potential clients, thus eliminating all the embar- rassment of being face to face with an individual. The National Portraiture Association. Surrey, is a registered charity which uses its funds to support scholarships and it has thus persuaded about 50 distin- guished artists to contribute their services, at reduced fees, in order to benefit the charity. In the past he has designed gravestones, com- memorative plaques, alphabets, exhibition pieces, glass bowls and medals. The fees charged have varied very little since I last wrote about the association nearly four years ago and the method for initiating a commission is much the same. Anybody inter- ested in having a portrait done should write to the association,, at the address given above, enclosing a 9p stamp, and they will then receive a brochure listing all the fees and the different mediums available chalk, pastels, oils and so on. From the illustrations enclosed in the brochure the potential client chooses the kind of style that most suits his taste and from there he can proceed with a commission. They include some very illustrious names like Michael Noakes almost every member of the Royal Family seems to have sat for him. The only artist of whom X have personal experience is Frances Baruch who has just completed a head of my daughter photographed above. She works from home at 16 Clifton Hill, London. NWS, and she works very quickly — she likes between four and six sittings, arranged very close together. She has most recently sculpted one of Sir Georg Solti's children and many other eminent people besides. ALMOST all good-class stationery shops and department stores have an excellent selection of writing-paper with initials incorporated somewhere into the design. Harrods, too, have a good stationery department and this pack of 15 monogrammed note cards, each In cream and navy border with gold letter, is accompanied by cream envelopes lined with navy bine. They will also send by post for 55p extra. The Yeoman gate illustrated is one of our range of craftsman made timber gates, constructed to give prolonged service. Other attractive designs are also available for the garden or farm. Sond 7p far a brochure or vtait m u Blddenden. Height Avt, table in antique shades ot green, red tan or dark raw lor order lorm. Mainland appro,. They have both been Deraarc ation lines and union requests and disc shows with Mr. U tries to leave som p d ne Peter Witt. Everyone tends to do nausic-on-ta: It has. Studio Piano-sirurummg musicians who prT , duC4fd by Mr. Three Force John's have been associated for anthems and the Funeral Sc a few musical seasons now, gen- traces all dating from the co orally mixing ancient and mod- poser's early twenties or befor - ern with fine artistry but, one were preceded by music from t gathers, not too good a response previous generation with whi at the box office. Their new he would have been famil. George Jeffries' v: Osnabrfick, where with each other. Why not. Havms spent Much of the time the station is H US,? In this case. In Nottingham they are engaged on various multi-racial projects. In Derby they have ventured abroad to broadcast programmes from their twin town in Germany. Davis, Joyce Blair and Leonie Cosman. What Derby last Friday when I was the BBC alms to offer is the piere rated more than a few choice between listening to one inches in the national Press but of five services, four of them they were all of major lraport- Network Radios 1 to 41 and one ance to this community: Billy full-blown musical. Anthony directed by Kenneth Chub, at: Quayle, a tough old Lear, should dishonesty in human relat: Ushers Carlin Music who are It will have an all-American cast not be missed. Reviewed Wed- ships. Reviewed Friday. A group of is already arranged. Jesse and m the Rat! S usual here. Thursday, the Cot? Lunchthne hour Daunt. Could that be a about South African politics, set Outside central London, ths a headc air about the studios was a good morning for the Solution to Problem No. E ment as the sline and pebbles mine when a big national storv K-B5: K- about how their shows are musical's cause. Witt is other. The best one I ever made safest recommendation since the latest antics of The Petr. Battles have been fou"ht here breaks io the area. He aware that many British Jews, was as an agent Would you Sleuth. Outstanding In the amateur ranks. Peter aJcGvoy was outstanding as a rare successful defending British champion. He per- formed with distinction in the U. Ohio, in the World Series of Golf. But by the time he got to Pacific Harbour. Fiji, for the Eisenhower Trophy, he had gone off the boil. British were made to look- sorry, chiefly because the outstanding American ' amateur of this and many former years. Bobby Clampett. I am grateful and feel that the time has not been wasted. X hope that these two hands, which occurred last week, will appeal to you. Here is the first: East came in with two hearts. West led the three of hearts, taken by the Ace, and East returned the nine of diamonds. After some thought I let this run. If the finesse was wrong. I had a loser in each suit, and my only hope of getting home appeared to be an endplay. I dismissed the possibility of a diamond ruff. I had to assume that East had at least two cards in the suit— if she had a single- ton. I was not going to make the contract anyhqw. West won with the King, returning the'two— I -was thank- ful to see East following suit — and I won in hand. When East dropped the Queen, it looked as if her hand pattern was S- 6 - 2 - 2. I made my other two j diamonds, on which East dis- carded two. East was securely endplayed, and her forced heart return gave me the ruff discard for which I had planned, allowing me to dispose of my losing dub while dummy ruffed. The second hand was far simpler, but it has more than one point of interest: West overcalled with two diamonds — now that is a bid with which one might find fault— and my partner doubled for penalties. This, of course. When West led the heart ten, I wan on the table, cashed the spade Ace, and returned the six of diamonds. East played low, and the nine won. Now West, who had found the best lead, instead of continuing with his other heart— his partner had dropped the eight at trick one — made the senseless return of a low diamond, which at pairs would have been disastrous. Ruffing in hand. Ten tricks were now certain, but I led ' the club five and finessed dummy's nine. East won with the King and led the Queen of hearts— too late. I won with the Ace. I did not care which defender had the Queen of clubs. Special Show offer: I only. Tahiti blue, tarcan red. Contact Mr. If you havs a fine classic or collectors car allow us to show it to over 2, prospective purchasers and realise its full value. Over cars expected, these will include: Be sure to request your entry form today, victoria and Co. Telex 8S Demonstrators available. Always 20 guaranteed used models in stock. White; L. Thuraan Holland. Pirc Defence. Results were N-B3: Yugoslavia and o? H 4 PJW ivmes, in tnai year, are the material loss. Obly Fischer among f! For Miles. Spassky in his toe used. Moreover, if the challenger manages to achieve' all this and beat Karpov at the end of -It, there is still a return match clause IS months later. Ribli, IBM potential challenger k that. Umre Amsterdam Was it players who. Spassky— -when It would have been most Interest- ing. Chess Is virtually unique as a game where practically all the international play is th the form of tournaments but the world title is decided by 1 a match , at long intervals. Chess grand- masters are rarely -at their peak for more than a decade , and so the opportunities -are too few, it is really time the. Even if you cram loot with goodies like baked is. British ledonian will introduce cing s on its. Farewell to the ie-elevcns. While the Canaries in general Balearic; and. Mcon Villas a wide choice in 31al la. Paul's Bay. I adore the Algarve at any j, 5,-w. These all. Lan- Paphos, the port which dates and Exchange Travel explain in fater J? Special terms io companies. Details and ilhisl rated brochure or request Tel: Frcnthl hllchC' Bjr. Phone , 01 lB': J1 2a 'I Swimmlne pool. Caribbean Corny cti on. Parker Road. Kent TN14 70 B. Mask of. Magic of Sardinia Ltd.. MedoUfon- Holidays, Edgware Rood.. Loudon W2 2DS. Mcon Winter Holidays. OSfc House. Seietire has id.. Tinii,-d ih. Ho Long Months of Waiting. Remits brpln inimediaiely. Lift- DJuamirs ivrh nuiues oCcr sclf-masiery wuhoin sell- taenfife. Papers arc set for: Girls who will be under 32 years on 1st September. Girls who will be under 13 years on 1st September. Girls who will be under 14 years on 1st September, In addition, either one of two Music scholarships of the same value may be awarded annually to girls of any age. Miss V. All levrh. Leclere - Villefranche-uir-Mer - Tel: Part Ldnr. London W1 on Tuesday. To re. By Order cf the Board P F. Roe Secretary 27 October Notes Only members holding fully paid Ordinary shares, or their duly appointed rcDrcsentatim. A member so entitled may appoint a nrovr. EcaR sea -5 ffy. Other Euro- foreigner. On a good day in buyers are telling our nego- eussion recently about by how rate controversy. John's Wood. X may own a thriving The attraction still conunues waiting to buy. X may own a thriving The attraction still conanues waiting to buy. British Ley- because of other factors. The houses and flats to get the fteel slower rate of growth. Ready St John's Wood Hampstead and of selling blight. So in land and the coal miners strike, "invaders" were treated of the city and decide on the to move into properties are the surrounds mean nothin'- to prices leaped upwards surpass- the pound staggers, inflation is exactly as that. London was a best place to buy. Your local of a three day week looms. John's Wood or conductors excepted. His business is failing; the buyer changed all that. If Mr. Y Stores became multi-lingual, influenced the market. NWS 4 Beds. NW3 5 Wellington Ct. Stephens Cl. James 5q. Mawes have received Instructions to sell what must be one or the most distinctive properties In St. Mawes in south-west Cornwall. Known as Trewithit, it enjoys a superb situation with views across the Fal Estuary - to Pendennis Head. It has a ducted oil-fired central heating system. Toler- unsaleable. The explanation flowering carnations for ex- oeoo That was the situation, plants. A beV y of buyers chasing of virus infections. Inemi noiiori hv. It infects a great actual losses caused by vtruj it. It varieties as well as seeking? They systemic insecticides In fact, care to experiment carbendawm: And, of course, battle cry of the front line Great faith was placed on the one corollary of this was that vendors was "find me a rich meristem method of prnpaga- any treatment that merely Arab". This was an anomalv tion 3 fe w cells excised suppressed the symptoms with- in itself as the majority of over- from ll,e fast-growing tips of out eliminating the virus was seas buyers probabiy came sh? The old story of. Peterhead 8 miles Aberdeen 28 miles. Oil Central Heating. Planning permission applied for hotel and extension. G0 per acre In all about 5SS. Let on single Agricultural Tenancy dated February 1. On Wednesday, 22nd November, , at p. Subject m Reterwo. Liverpool 2. A M Cl Magnificent villa situated in its own beautiful seven acre grounds, superb views to Nice, Cannes and the Mediterranean. The house which will accommodate up to 20 people in great comfort, has 10 bedrooms. Two additional cottages in the grounds. The property is for sale with all its quality furnishing at a substantial price. For further details please apply: Thu is the ideal location for chose seeking die best of both worldi. Diane Steward Tel: Excellent swimming— warmest salt wacer. Formerly supported three farms. Chartered Land Agena. Lemon Villas. Truro Tel: South Coast and St. Viewi to the sea oeer otatefuf wooded parkland of S4 acres. Suitable far prime occupation, institutional use or conversion into fiats. Histone I4ch Century buildina at present subl-ng for conversion. Far required Tr crivaie l rr. The newly built: It has 2 conference rooms and a grill restaurant The hotel is centrally situated, but in a secluded spot The hotel is for sale and a quick settlement is wanted, Bergen has rich traditions in tourism and business travel. Would interested buyers please. Tgtotlan, IrtvesUnem areas. HIKpo Home. Honmd Lana. These are ideal for sending to rela- tions and friends at home and overseas, as well as for your own discerning enjoy- ment DEPT. Strum pihaw, Norwich Tel: Telex-- Hampers. Colour brochure on request public notices. Edlnbuntti EBiraR. They make marvellous presents.. Since I last wore about them they have added: I'm convinced, is an art and some penple arc much better at It than others. The old cliche about it being the thought and not the cost that really matters is. Even quite ordinary items like stationery, key-rings, cuff-links, can be transformed into something special if enough imagination and care has gone into choosing them. The one thing they all require is some advance planning. You really must order now if you want to he sure of them being ready for Christmas. You can send a photograph or the message to Sylvia's and they will be dealt with by mail of, alternatively they can be done while you wait. Some people ask for logos, letterheads, others like loving messages. They could be a good addition to a Christmas stocking. Cyril Came and Son, Wentworth Avenue, London N3 do several of the usual personalised items track-suits, towels etc but have recently introduced a nightdress rase which looks quite pretty. In red. Orders take about three weeks. Stephanie Roberts dues very beautiful batik w'ork on silk and can produce scarves that are very distinguished and very individual. She can make scarves of any and every colour except black and you can order them with a name in one corner or with the name used as the motif going right round the whole scarf. There are several sizes. The silk is very fine, the batik work exquisite and you can virtually ask for your own coiourways or design. The pies roust be large— 13 lb, b or 30 Jb. Orders will take about 10 days. Box 19, Swindon. If yon know a golf fanatic Kaleidoscope can also provide a pair of hallmarked sterling silver ball-markers engraved with up to four initials apiece. They are supplied fn a little leather carrying case. Portraits by Care! She loves working in quilted and padded satin which she often prints with her own rather special flowery designs. She has now devised a series of special white polyester satin hot waler-hottle covers and these can be ordered with any special Dame or theme in green, yellow, fuchsia, purple or blue. Special orders can be made to Fitzroy Frag the name of Rose Elliott's company. Box , 4 Reckitt Road, London W4. When ordering you should include your phone number as Rose Elliott may like to consult you about colours or 'other details. She will also send a list of different types of script, flowers or whatever else you would like included in the design. Orders should take up to three weeks. The bottle You must specify whether it is to be 11 ins. There is a choice of four different sorts of canvas 12 holes to the inch is the most popular. The Needle- woman Shop of Regent Street can give advice about choosing. It looks to me quite difficult to do in that although the full-colour photograph 'Is printed on to the canvas there are no absolute directions over which colours to put where and bringing human features to life is not easy. Needlecraft, 60, Holmes dale Road. Teddington, Middlesex. Delivery is about four weeks. Make sure that the print you send is clear; jf necessary cut out irrelevant details in the background. The designs are all, naturally enough, on racing themes, and I suppose on the assumption that racing circles are well-heeled, the prices are not low. V V ViT. MOST of us tend to think that commissioning portraits or sculptures is the province of the very rich or of grand com- panies which want to honour their distinguished presidents. Not many people realise that it is easier, less daunting and Jess expensive than they might imagine to have carried out either a portrait or a sculpture of either themselves or some- body they are fond of. The most reasonable method that I know of unless you have access to an Impecunious and talented future Augustus John is through two organisations that specialise in sifting both artists and potential clients, thus eliminating all the embar- rassment of being face to face with an individual. The National Portraiture Association. Surrey, is a registered charity which uses its funds to support scholarships and it has thus persuaded about 50 distin- guished artists to contribute their services, at reduced fees, in order to benefit the charity. In the past he has designed gravestones, com- memorative plaques, alphabets, exhibition pieces, glass bowls and medals. The fees charged have varied very little since I last wrote about the association nearly four years ago and the method for initiating a commission is much the same. Anybody inter- ested in having a portrait done should write to the association,, at the address given above, enclosing a 9p stamp, and they will then receive a brochure listing all the fees and the different mediums available chalk, pastels, oils and so on. From the illustrations enclosed in the brochure the potential client chooses the kind of style that most suits his taste and from there he can proceed with a commission. They include some very illustrious names like Michael Noakes almost every member of the Royal Family seems to have sat for him. The only artist of whom X have personal experience is Frances Baruch who has just completed a head of my daughter photographed above. She works from home at 16 Clifton Hill, London. NWS, and she works very quickly — she likes between four and six sittings, arranged very close together. She has most recently sculpted one of Sir Georg Solti's children and many other eminent people besides. ALMOST all good-class stationery shops and department stores have an excellent selection of writing-paper with initials incorporated somewhere into the design. Harrods, too, have a good stationery department and this pack of 15 monogrammed note cards, each In cream and navy border with gold letter, is accompanied by cream envelopes lined with navy bine. They will also send by post for 55p extra. The Yeoman gate illustrated is one of our range of craftsman made timber gates, constructed to give prolonged service. Other attractive designs are also available for the garden or farm. Sond 7p far a brochure or vtait m u Blddenden. Height Avt, table in antique shades ot green, red tan or dark raw lor order lorm. Mainland appro,. They have both been Deraarc ation lines and union requests and disc shows with Mr. U tries to leave som p d ne Peter Witt. Everyone tends to do nausic-on-ta: It has. Studio Piano-sirurummg musicians who prT , duC4fd by Mr. Three Force John's have been associated for anthems and the Funeral Sc a few musical seasons now, gen- traces all dating from the co orally mixing ancient and mod- poser's early twenties or befor - ern with fine artistry but, one were preceded by music from t gathers, not too good a response previous generation with whi at the box office. Their new he would have been famil. George Jeffries' v: Osnabrfick, where with each other. Why not. Havms spent Much of the time the station is H US,? In this case. In Nottingham they are engaged on various multi-racial projects. It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visualization techniques. We distinguished 3 generations of midgut loops. The topography of primary and secondary loops was constant, but that of tertiary loops not. The orientation of the primary loop changed from sagittal to transverse due to the descent of ventral structures in a body with a still helical body axis. The 1st secondary loop duodenum, proximal jejunum developed intraabdominally towards a left-sided position. The 2nd secondary loop distal jejunum assumed a left-sided position inside the hernia before returning, while the 3rd and 4th secondary loops retained near-midline positions. Intestinal return into the abdomen resembled a backward sliding movement. Only after return, the 4th secondary loop distal ileum, cecum rapidly "slid" into the right lower abdomen. The seemingly random position of the tertiary small-intestinal loops may have a biomechanical origin. The interpretation of "intestinal rotation" as a mechanistic rather than a descriptive concept underlies much of the confusion accompanying the physiological herniation. We argue, instead, that the concept of "en-bloc rotation" of the developing midgut is a fallacy of schematic drawings. Primary, secondary and tertiary loops arise in a hierarchical fashion. The predictable position and growth of secondary loops is pre-patterned and determines adult intestinal topography. We hypothesize based on published accounts that malrotations result from stunted development of secondary loops. Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis. Twenty consecutive patients with cirrhosis were randomized to recombinant human growth hormone Norditropin, 4 I. The serum concentrations of insulin-like growth factor-I in the recombinant No significant changes were seen in the area under the curve for biochemical liver function tests. We conclude that administration of recombinant human growth hormone induces This research postulates that prostate cancer cells commandeer this normal epithelial-mesenchymal signaling pathway to recruit stromal cells to support abnormal tumor growth and tests the hypothesis Potency testing of mesenchymal stromal cell growth expanded in human platelet lysate from different human tissues. Mesenchymal stromal cells MSCs have been largely investigated, in the past decade, as potential therapeutic strategies for various acute and chronic pathological conditions. MSCs isolated from different sources, such as bone marrow BM , umbilical cord tissue UCT and adipose tissue AT , share many biological features, although they may show some differences on cumulative yield, proliferative ability and differentiation potential. The standardization of MSCs growth and their functional amplification is a mandatory objective of cell therapies. The aim of this study was to evaluate the cumulative yield and the ex vivo amplification potential of MSCs obtained from various sources and different subjects, using defined culture conditions with a standardized platelet lysate PL as growth stimulus. MSCs morphology, phenotype, differentiation potential, and immunomodulatory properties were also investigated to evaluate their biological characteristics. The use of standardized PL-based culture conditions resulted in a very low variability of MSC growth. The adoption of standardized culture conditions may help researchers and clinicians to reveal particular characteristics and inter-individual variability of MSCs sourced from different tissues. These data will be beneficial to set the standards for tissue collection and MSCs clinical-scale expansion both for cell banking. Full Text Available It is obvious that human capital is critical for economic growth. The paper aims to investigate the relationships between human capital and economic growth in the romanian economy by analyzing the correlations between statistical variables measuring human capital and economic growth. Using a regression model, it is analyzed the impact of the educational and health capital on the economic output. In the paper, a linear regression model of the relation of human capital to economic growth is subjet of an empirical analysis, firstly, taking into consideration only education as human capital and secondly, incorporating in the model the both components: A strong correlation between educational variables and GDP, for , was found. The quality of the educational capital has a determinant role in the economic growth , the highly educated people are influencing more the economic output than the secondary educated ones. GDP per capita is negatively correlated with the number of worked hours and positively influenced by the life expectancy. The most important contribution contained by this article refers to the incorporation of the two components of human capital in the same econometric model explaining the economic growth. The added value of paper consists in offering suggestions and orientation for national educational policies. Human fetal growth is constrained below optimal for perinatal survival. Vasak, B. ObjectiveThe use of fetal growth charts assumes that the optimal size at birth is at the 50 th birth-weight centile, but interaction between maternal constraints on fetal growth and the risks associated with small and large fetal size at birth may indicate that this assumption is not valid for. Abstract The development of a country usually determined by the human development index HDI. Per capita income education and health are the three most important components of human development index. The purpose of this research is to understand the relationship among human development index to income per capita growth and poverty alleviation in Indonesia with cross-section data from 30 provinces period year. The result of this research were a income per capita growth was not sign Human corpus luteum: Epidermal growth factor receptors are present in many reproductive tissues but have not been demonstrated in the human corpus luteum. To determine the presence of epidermal growth factor receptors and its binding characteristics, we carried out studies on the plasma cell membrane fraction of seven human corpora lutea days 16 to 25 of the menstrual cycle. Specific epidermal growth factor receptors were present in human corpus luteum. Insulin, nerve growth factor, and human chorionic gonadotropin did not competitively displace epidermal growth factor binding. The optimal conditions for corpus luteum-epidermal growth factor receptor binding were found to be incubation for 2 hours at 4 degrees C with micrograms plasma membrane protein and femtomol I-epidermal growth factor per incubate. In two regressing corpora lutea obtained on days 2 and 3 of the menstrual cycle, there was no detectable specific epidermal growth factor receptor binding activity. Similarly no epidermal growth factor receptor binding activity could be detected in ovarian stromal tissue. Our findings demonstrate that specific receptors for epidermal growth factor are present in the human corpus luteum. The physiologic significance of epidermal growth factor receptors in human corpus luteum is unknown, but epidermal growth factor may be involved in intragonadal regulation of luteal function. Position stand on androgen and human growth hormone use. Position stand on Androgen and human growth hormone use. J Strength Cond Res 23 5: S1-S59, Perceived yet often misunderstood demands of a sport, overt benefits of anabolic drugs, and the inability to be offered any effective alternatives has fueled anabolic drug abuse despite any consequences. Motivational interactions with many situational demands including the desire for improved body image, sport performance, physical function, and body size influence and fuel such negative decisions. Positive countermeasures to deter the abuse of anabolic drugs are complex and yet unclear. Furthermore, anabolic drugs work and the optimized training and nutritional programs needed to cut into the magnitude of improvement mediated by drug abuse require more work, dedication, and preparation on the part of both athletes and coaches alike. Few shortcuts are available to the athlete who desires to train naturally. Historically, the NSCA has placed an emphasis on education to help athletes, coaches, and strength and conditioning professionals become more knowledgeable, highly skilled, and technically trained in their approach to exercise program design and implementation. Optimizing nutritional strategies are a vital interface to help cope with exercise and sport demands. In addition, research-based supplements will also have to be acknowledged as a strategic set of tools e. Resistance exercise is the most effective anabolic form of exercise, and over the past 20 years, the research base for resistance exercise has just started to develop to a significant volume of work to help in the decision-making process in program design. The interface with nutritional strategies has been less. Growth kinetics of four human breast carcinomas grown in nude mice. The three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations. In the present study one estrogen and progesterone receptor-negative T60 and three receptor-positive Br, MCF-7, T61 human breast cancer xenografts The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis performed on fine-needle aspirations. The results showed that the tumors had growth kinetics comparable to other human tumor types On the growth rate of gallstones in the human gallbladder. The growth rate of a single symmetrically oval shaped gallbladder stone weighing The length of the stone was measured by ultrasonography and the growth rate was found to be linear with time, with a value of 0. The morphology and metallic ion chemical composition of the large stone and of a randomly selected small stone weighing about 1. It was found that the large stone contained besides calcium also lead, whereas the small stone contained mainly calcium. It is possible that the lead causes a difference in mechanism between the growth of a single large and growth of multiple small gallstones. Full Text Available In the process of developing economy in a whole and continuously, the macro economy stability of acountry is an essential prerequisite for producing a quality economic growth. For achieving the qualityeconomic growth , there should be a continuous capital human investment and the use of continuousscience and technology IPTEK. The process of developing economy will be able to transform thesociety condition from vicious circle to virtuous circle condition if the growth of economy is qualified.. Quality of growth ; human capital, technology and virtuous circle. Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor. To determine if fibroblasts could be a source of fibroblast growth factor FGF in tissue, cells were initiated in culture from newborn human foreskin. Fibroblast cell lysates promoted radiolabeled thymidine uptake by cultured quiescent fibroblasts. Seventy-nine percent of the growth -promoting activity of lysates was recovered from heparin-Sepharose. The heparin-binding growth factor reacted on immunoblots with antiserum to human placenta-derived basic FGF and competed with iodinated basic FGF for binding to antiserum to bFGF synthetic peptide. To confirm that fibroblasts were the source of the growth factor, cell lysates were prepared from cells incubated with radiolabeled methionine. Heparin affinity purified material was immunoprecipitated with basic FGF antiserum and electrophoresed. Radiolabeled material was detected on gel autoradiographs in the same molecular weight region as authentic iodinated basic FGF. The findings are consistant with the notion that cultured fibroblasts express basic FGF. As these cells also respond to the mitogen, it is possible that the regulation of their growth is under autocrine control. Fibroblasts may be an important source of the growth factor in tissue. Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Human embryonic stem cells hESCs are thought to be a promising cell source for cell transplantation therapy. For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin rhLM isoforms on the undifferentiated growth of hESCs. The hESCs proliferated on these three rhLMs for several passages while preserving their pluripotency. We analyzed the expression and function of p8 in pancreatic cancer-derived cells. Methods Expression of p8 was silenced in the human pancreatic cancer cell lines Panc-1 and BxPc-3 by infection with a retrovirus expressing p8 RNA in the antisense orientation. Cell growth was measured in control and p8-silenced cells. Influence on p8 expression of the induction of intracellular pathways promoting cellular growth or growth arrest was monitored. Results p8-silenced cells grew more rapidly than control cells transfected with the empty retrovirus. Conclusions p8 inhibits the growth of human pancreatic cancer cells. These results suggest that p8 belongs to a pathway regulating the growth of pancreatic cancer cells. A comparison of fatigue crack growth in human enamel and hydroxyapatite. Cracks and craze lines are often observed in the enamel of human teeth, but they rarely cause tooth fracture. The present study evaluates fatigue crack growth in human enamel, and compares that to the fatigue response of sintered hydroxyapatite HAp with similar crystallinity, chemistry and density. The specimens were subjected to mode I cyclic loads and the steady state crack growth responses were modeled using the Paris Law. In regions of decussation, the microstructure promoted microcracking, crack bridging, crack deflection and crack bifurcation. Working in concert, these mechanisms increased the crack growth resistance and resulted in a sensitivity to crack growth m similar to bone and lower than that of human dentin. These mechanisms of toughening were not observed in the crack growth response of the sintered HAp. While enamel is the most highly mineralized tissue of the human body, the microstructural arrangement of the prisms promotes exceptional resistance to crack growth. The Case of Macedonia. Full Text Available The main objective of the paper is to explore the assumption if the lack of skilled and well-educated workforces human capital holds a potential of a binding constraint to economic growth of the Macedonian economy. The empirical techniques used in this paper are: The estimated results indicate an important contribution of human capital to economic growth its relative contribution in terms of growth rate composition is approximately 22 percent. The macro and micro assessment of the rate of return on investment in human capital shows that the rate of return to higher education is significantly superior to corresponding returns to secondary education. Finally, the international benchmark analysis helps in comparative human capital impact analysis educational structure of labor force in the wider region. From the birth of the human capital theory, economists were interested to find evidences showing the impact of the human capital on the economic output, discussing and debating more or less the effect of economic growth on the accumulation of human capital in the economy and the association between education and health. The paper aims to test several econometric models to explain the relationship between human capital and economic output. Using World Bank data, 17 countries with the fastest e Insulin infusion reduces hepatocyte growth factor in lean humans. Plasma Hepatocyte Growth Factor HGF is significantly elevated in obesity and may contribute to vascular disease, metabolic syndrome or cancer in obese individuals. The current studies were done to determine if hyperinsulinemia increases plasma HGF. Twenty-two parti Influence of topical human epidermal growth factor on postkeratoplasty re-epithelialisation. Dellaert; T. Casey; S. Wiffen; J. Gordon Jocelynne ; P. Geerards Annette ; W. Rijneveld Wilhelmina ; L. Remeijer Lies ; W. Beekhuis Houdijn ; P. Mulder Paul. To test the efficacy and safety of recombinant human epidermal growth factor hEGF on corneal re-epithelialisation following penetrating keratoplasty. A prospective, randomised, placebo controlled study was carried out in which patients were. Human milk oligosaccharides inhibit growth of group B Streptococcus. Streptococcus agalactiae group B Streptococcus, GBS is a leading cause of invasive bacterial infections in newborns, typically acquired vertically during childbirth secondary to maternal vaginal colonization. Human milk oligosaccharides HMOs have important nutritional and biological activities. Human Capital and Economic Growth: The study examines the role of human capital in the economic growth of Pakistan by using primary, secondary and higher education enrolments as proxies for human capital in three different specifications. The idea behind these models is to find out the most relevant level of education in terms of its contribution in economic growth. The order of integration of the variables is checked through Augmented Dickey Fuller and Phillips Perron test. In order to find out the evidences of the long run r Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure? Growth hormone treatment has gained attention over the past decade as a treatment for heart failure. Human growth hormone HGH must be administered by injections usually daily , so there is considerable advantage to stimulation of endogenous secretion by amino acid-based nutritional. Inhibition of uropathogenic biofilm growth on silicone rubber in human urine by lactobacilli - a teleologic approach. The ability of three Lactobacillus strains to inhibit the adhesion and growth of naturally occurring uropathogens on silicone rubber was investigated in human urine. The importance of biosurfactant production by Lactobacillus in discouraging uropathogen growth was determined in relation to the. Monitoring human growth and development: Villar, Jose; Papageorghiou, Aris T. Alison; Gravett, Michael G. A comprehensive set of fully integrated anthropometric measures is needed to evaluate human growth from conception to infancy so that consistent judgments can be made about the appropriateness of fetal and infant growth. At present, there are 2 barriers to this strategy. First, descriptive reference. An Interactive Effect. Full Text Available Various studies have focused on the relationship between human capital and economic growth all over the world. However, there is still a missing gap on the joint influence of human capital investment components on economic growth particularly in Nigeria. This study therefore examines the interactive effects of the relationship between human capital investment components and economic growth in Nigeria for the period of — The study employed secondary annual data on education expenditure, health expenditure, real gross domestic product and gross capital formation obtained from the Central Bank Statistical bulletin, The results of the study showed that there was positive and significant relationship between the interactive effects of human capital components and growth in Nigeria. Human epidermal growth factor: Epidermal growth factor EGF , a 53 amino acid polypeptide, was first isolated by Cohen. EGF's growth -promoting activity is not limited to epidermal cells, but is expressed on a wide variety of tissues derived from a number of different species. Using these assays, the molecular size of hEGF in human body fluids and tissues was evaluated, and partial characterization of a high molecular weight form of hEGF isolated from human urine was carried out. The concentrations of immunoreactive hEGF were also determined in human tissues and plasma after extraction either with cationic exchange chromatography or with immunoaffinity chromatography. Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature. We studied nine children who had received cranial irradiation for various malignancies and subsequently experienced decreased growth velocity. Their response to standard growth hormone stimulation and release tests were compared with that in seven children with classic GH deficiency and in 24 short normal control subjects. Only two of nine patients had a normal response to insulin hypoglycemia, with no significant differences in the mean maximal response of the radiation and the GH-deficient groups. Pulsatile secretion was not significantly different in the radiation and GH-deficient groups, but was different in the radiation and normal groups. All subjects in the GH-deficient and radiation groups were given human growth hormone for 1 year. Growth velocity increased in all, with no significant difference in the response of the two groups when comparing the z scores for growth velocity of each subject's bone age. We recommend a 6-month trial of hGH in children who have had cranial radiation and are in prolonged remission with a decreased growth velocity, as there is no completely reliable combination of GH stimulation or release tests to determine their response. Stimulation of class II molecules by monoclonal antibodies mAbs or bacterial superantigens induces protein tyrosine phosphorylation through activation of protein tyrosine kinases in T cells, and class II signals There was no correlation between T cell responsiveness to class II and the cytokine production profile of the T cell in question. Here, we studied further the role of class II molecules in the regulation of T cell growth. Human disturbance influences reproductive success and growth rate in California sea lions Zalophus californianus. Full Text Available The environment is currently undergoing changes at both global e. Many of these changes, such as human disturbance, have an anthropogenic origin and therefore may be mitigated by management action. To do so requires an understanding of the impact of human activities and changing environmental conditions on population dynamics. We investigated the influence of human activity on important life history parameters reproductive rate, and body condition, and growth rate of neonate pups for California sea lions Zalophus californianus in the Gulf of California, Mexico. Increased human presence was associated with lower reproductive rates, which translated into reduced long-term population growth rates and suggested that human activities are a disturbance that could lead to population declines. We also observed higher body growth rates in pups with increased exposure to humans. Increased growth rates in pups may reflect a density dependent response to declining reproductive rates e. Our results highlight the potentially complex changes in life history parameters that may result from human disturbance, and their implication for population dynamics. We recommend careful monitoring of human activities in the Gulf of California and emphasize the importance of management strategies that explicitly consider the potential impact of human activities such as ecotourism on vertebrate populations. HSPGs bind to numerous growth factor ligands including fibroblast growth factors FGF , epidermal growth factors EGF , and vascular endothelial growth factors VEGF , and are critically important in the context of cancer cell growth , invasion, and metastasis. We hypothesized that sulfatase activity in the tumor microenvironment would regulate tumor growth in vivo. We established a model of stable expression of sulfatases in the human breast cancer cell line MDA-MB and purified recombinant human Sulfatase 2 rhSulf2 for exogenous administration. In vitro studies were performed to measure effects on breast cancer cell invasion and proliferation, and groups were statistically compared using Student's t-test. The effects of hSulf2 on tumor progression were tested using in vivo xenografts with two methods..

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Employing highly purified monomeric hormone it proved possible, by the iodogen procedure, to prepare a labelled product of high specific activity irrespective of temperature. However, in radioiodinations performed at ambient temperature 20 to 25 degrees significant amounts of the Rin aoki porn etotic clips hormone were in an aggregated form which was less immunoreactive than the I-labelled monomeric hormone. From a set of 31 three-dimensional CT scans we model the temporal shape and size of the human mandible.

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The role of epidermal growth factor EGF in oncogenesis and progression of malignant tumors is a subject of vast interest. Continue reading this study, radioimmunoassay and radioreceptor assay of EGF were established.

EGF contents in malignant and benign pancreatic tumors, in normal pancreas tissue, and in culture media of a human pancreatic carcinoma cell line were determined. EGF receptor binding studies were performed.

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Sir Geoffrey Howe, month. Conservative earlier thLs i. He made it clear, however, that he believed Arm. He preferred to stress freedom from government inicrferenci? John Paraue. Pardoe said Britain had 1 1 pea n bu- again. Lf we did not join Government in a difficult uur partners iu the system in linn. A Commons debale the New Year we would be been promised on the Euro- forced sooner or later to accept a Monetary System when a a i-mninan currency fashioned by siun is taken in December others. John Collins, managing director of Park West Motors, [ford. Essex, which imports Toyota cars, was delighted, if not a little surprised, by ihe news of ihe loan which will enable him lo buy xi new garage and. The corporation was 3 little coy about the deal. This, departure mla imports financing was iustjfled largely on the hasis of Mr. Collins be-. Collins did nut import Tuyotas. It said: Coilins said that when he applied for the loan he had expected the nature of hfs trade to be a problem. Finance had been difficult to find, but. Peter Foden-Pattin-: Conservative sun. Minet Agencies, and for Thanei East, about the Mr. Confidence was also expressed m Mr. Bernard Wex. The dispute over productivity is to be ihe subject of talks with Mr. It has also been the cause of warnings by the construction company that if payments con- tinue- to he withheld it might be forced to abandon the pro- ject, which. British Bridge Builders ruled twu weeks ago that if the Free- man Fox targets were not met the cable spinners would lose bonus payments equivalent lo about one third of weekly earnings. Haydon Glen, clerk to the Board, said that outstanding issues in the dispute would have to be- settled by arbitration or in the High Court. British Industry indicated last The campaign was formed in night that ii took seriously pro- response to a Labour document, posals by sections of the Labour suggesting a National Construc- Party for nationalisation of the tion Corporation on the lines of building industry. Erie Heffer, thai Labour should argue for step-by-slep public ownership of the construction industry. However, the Labour Party planned nationalisation. Water workers. The employer f had to provide the season ticket years ago and most annual sea- son tickets were now bought. Lins it Dispute delays frigate launch which would not be cashable by the employee, and he could not reimburse him for a ticket already bought. The frigate represent a key public sector Brilliant was to have been group in the low-pay area which launched next week. British Finally, the employee's earn- Mr. The Inland Revenue said yesterday that additional qualifi- cations. And it was likely most of the Discussion ranged round im- proving productivity by natural wastage. The management is stilt seeking to reduce the labour force by several thousand. Talks on this are At yesterday's meeting of Iho expected to take weks. The question of what cate- gories of workers make up ihe grades — and their rates — has stili not been settled. Saturday night shift, it added. Heffer was ownership, as the TUC had pru- addressmg. TASS, the engineering sluff union, yesterday issued a strong denial of charges reported to have been made last weekend by Mr. Michael Edwardes. BL chairman. TASS national lift. He Is ton. Rudolph Agnew, deputy chairman, said yesterday that the study would be finished in a matter of weeks. The venture would be on a small scale, producing less than half the amount of tin -of Wheal Jane, near Truro. Wheal Jane had an output of That mine is now on a care- and-malatenance basts after production. Robert L. Sprinkel— bis reluctance to accept Government money and the fact that he is willing tu put his own money ih, H Said Lord Erroll of Hale, the ehairman. Bat he held to the basic Gold Fields position on Wheal Jane: Bnt Lord Errol! As far as other Cornish activities are concerned,. Gold Fields is evaluating the results of drilling at two neglhbonring sites. ICI said yesterday that it did not yet have firm plans for the site, but it could follow the pattern of its biggest petro- chemicals site at Wilton on Teeiside. Products could include ammo nia and methanol— derived from natural gas — as wel-1 as oiher basic petrochemicals and down- stream products such as plasucs and fibres. It is also involved in exploration pro grammes on various parts of the UK continental shelf In the North Sea and to the west oF the Shetlands. It has developed more than 1. Il is thought however, that ICI is anxious not to concentrate its resources too heavily In one area. It has carried out land and seabed surveys at an estuary site in Tayside, Scotland. The site is at Barry Buddon. The company is also under stood to have investigated the Humber estuary in England. Both the Humber and Tay offer sites with fiat land and access to. The com puny has held a series of dis- cussions with the Scottish Office shout the Tayside location. First news of the plan has already brought mixed reactions from local interests on Tayside. Dundee has high unemployment It might therefore be expected 3 hili 1 in spa,n - The deposit certificates trial. He was jointly charged. Felicio Morelia, the former Banking Corporation and its head of both international Bank, associated company, European ing and European and Arabian, and Arabian Bank, both regis- who was jailed for three years tered in Anquilia. Unterlaggauer has prison sentence at the Old Bailey, spent 12 months in custody, he Dr. Heinrich Peter Unlertag- will be released on Honda when gauer, born In Austria, had a riepnrtatinn order will be con- pleaded guilty to charges of issu- sirlcrert. He claims io have a ing false certificates of deposit job awaiting him in Germany, in order to acquire seven hotels Mr. Joseph Khalife is still on in Spain. The deposit certificates trial. He Detective Chier Inspector Roy has pleaded no't guilty-. Elsey, he admitted signing 15 European and Arabian Bank certificates — together with has no connection with the another former employee of European Arab Bank group International Banking Corpora- Industrial Banking Cornoration" non who has since left the UK. Uo terlaggauer's sentence the c ame name. EG Commission to make their eipalities: Most of the steel in an average British car body is sheet steel. There was little to cheer in the silt market either, as a further rise in U. Interest rates British interest rates are still high enough to attract inflows from the United States, even after the most recent rise in the U. As the forward discount on ster- ling has shrunk almost to par. On a simpler level, it does seem that confidence in sterling, as against lack of confidence in the dollar, has been growing over the last week, with the foreign exchange markets appealing rather less worried about news on the labour front. There has been some nervous- ness i hat the Bank of England might intervene to stop sterling rising fun her. Next week the official cur- rency reserve figures for October will be published, and they are expected to show that the Bank's intervention has been limited. But any sign aF funds flowing heavily into London could be worrying to the markets, unless of course foreign money flows into gilts and encourages the home-based institutions tu jump in too. At the moment, though, short money rates are so high that they weaken the inducement to commit money to gilts. Drug problems Beecham's share price took a rumble last week on news that the company may bo forced to cut its drug prices further in the U. Analysts, on lie other hand, feel the market reaction may be somewhat overdone. The issues arc undoubtedly complex and involve a fair bit of unfinished litigation. Beecham, for example, is still suing its main U. But Bristol and Beecham have both been on the receiving end under U. It comes, moreover, in the wake of average amoxy- cillin price cuts since July of roughly 20 per cent. This has already been noted by dose ob- servers of the U. In the short term, despite some loss in market share. Although longer term growth prospects from the U. After sliced bread Now that the loss-making bread baking business is out of the way. A 98 Offer from Wm. Baird lapsed De Beers Dfd. Group Financial Gp. So loss elimination should be worth Elsewhere the milling division did better, and grocery products and meat are singled out as having done well. The one question for the market is haw quickly Spillers will restore its dividead. Last year when profits collapsed the dividend was slashed from 2. The market is banking on Spillers going some way to restoring the divi- dend this year. For the whole of last year losses in the U. This left group profits only. The problems seem to have been twofold. First, Mothercare j set up its U. The bulk of these were under 1. Secondly, the Mothercare management in the U. Strenuous efforts, including top management changes, are now going on to turn the pro- ject round. And meanwhile the stores operating under the Mothercare name are apparently doing well. Impressive though ' the Dow's losses have been in the last two weeks, they in fact understate the broad market decline, notably the routing of secondary stocks. The American Stock Exchange which hosts many' of the smaller, less capitalised companies, has seen its index tumble by a formidable 17 per cent front its peak in mid- September, while the Dow has suffered a more modest 9. On Thursday the Dow drew back by 9. But yesterday the decline quickened and the Dow dropped Technical analysts looking for a rainbow claim they are only mildly surprised at the slaughter. They point out that before the rally which started last April the market bad been seriously weakened by the Blue Chips — the IB Ms and Polaroid; of this world — while the smaller stocks had shown positive strength for most of last year. Meanwhile, away from the technicians' charts investors have found that the world is too much with them. In a brief but grisly recap the week's news has included a rise in commercial hanking prime rates to per cent, the. A 19th-century Russian novelist would have been strained to write a more depressing scenario There is as much scepticism in the U. Somewhat curiously there has been no attempt berc to cite the achievements of Britain's voluntary policy in justification for the new approach when on the surface the prospects for success are at least as good as they were in Britain. When they have been at their most negative they have simply assumed that conditions have been so bad. Perhaps the time has come again to search for a new meta- phor. The latest batch of quarterly results from North American groups show- a dis- tinct improvement over a year ago, if not in profits at least in sales. It is tempting to see the figures as the definite start nf a new trend, but the U. Another of the U. It came back into Ihe black in the second quarter and in the three months to No. The said Minute is in lhe wordsand figures following: Charles Barber, the Asarco chairman. Tm iD the same three mouths of Although zinc prices hafe been at lower levels than last year, lead demand has been strong and looks like remaining so. Further evidence nf the revival in the copper industry came from Freeport Minerals, whose profits in the September quarter jumped sharply to S7. In contrast the market for tin has been consistently strong. But this bas not provoked any consistent rise in Malaysian production, as the accamsnyiaz fable shows. A combination of higher taxes ami. Sprinkel publicly to disclose his intention of try- ing to put together a financial package allowing him to take- over the Wheal Jane tin mine in Cornwall. Sprinkel is an American entrepreneur, now resident in Derbyshire, and within the next two weeks he hopes to make Consolidated Gold Fields, the present owners, a definite offer. Ayer Hitam - Be r junta! Piran — Far East St. Piran— UK South Crafty Southern Malayan Tanjong Tong kah Harbour 42 40 Tronoh i Figures hi elude low-grade material f Not yet a puts are shown in metric tonnes of tin concentrates. Sept, Atut. Another metal which has strengthened its price despite the recession is molybdenum. A in ax. This level was reached four months before bullion peaked ar SI Political factors arc one reason for the poor general per- formance of golds. A good ex- ample of the short-term effects arose last week, during the visit of the five western foreign ministers to Pretoria. On tiie Wednesday, the gold price hit a new record las it then was of S Politics, however. Mine violence has died down, the mine- have obtained a better spread of labour, which five years ago ua. One overriding reason for the low level of interest in golds is ihe growth of ihe gold furures markets in the U. In these markets did not exist and physical gold ownership was only authorised early in So gold shares — U. Wnn trading in the U. This aside. The table shows U. The top 15 account for R5. However, the table shows the U. In addition to U. There has also been a massive flow of De Beers shares to the U. Johannesburg brokers estimate 10 per cent of De Beers is now held in the U. Except to the U. With the local institutions traditionally more interested in industrials than golds and the European investor virtually out nf the market for a mixture of political and financial. But the counter- pull of the future markets and the high existing level of U. Gcfinlrl 45 Western Holds. Brand 24 66 Pres. Totals 5, Tx Gar t m ore Fmxl Managers Lid. Eamonn Fingleton iks at ways to cut the cost. But unless you are care- you will lose about T per of your capital in dealing ; every time you switch, point is thai the dealing of a switch is often the difference between the r" price at which unit: He needs to choose a? Jives tors who get into units. These can he useful when the outlook for shares turns choppy. With some groups— Hambro. First switch free. Cutting the bother of Child Benefits ing in various types of equities Some unscrupulous brokers for bond investors. Barclays have been criticised recently for Unicorn bondholders cannot drumming up commission by link their investment to any encouraging unnecessary switch- particular unit trust but instead ing. Such brokers are unlikely it is put in a managed fund invested in a selection of the group's trusts. The managers vary the mix as market conditions dictate. Barclays, for instance, usually deducts in full the amount of any commis- for cent initial commission introducing new business. Indications for the second and third weeks arc that sales are lower, bill still very strong. The sudden sales surge re- flects the fact that -from October 1. Yet this jump in sales no- where near represents the full potential that could have taken place. There are about lira persons holding these certifi- cates, of whom over lm held the maximum holding before October 1. Looking to the immediate future' and the likely movement in the Retail Price Index, the official forecasts are that the year-on-year increase will re- main around S per cent for the next six months. But unofficial forecasts of r the rise of the RPI in the next 12 months vary from 6 to 12 per cent depending on the view on forthcoming wase settlements. Stockbrokers Phillips anti Drew, for example, is forecasting an They have lo watch patiently as the assistant goes through the palaver of stamping the benefit book, removing a counterfoil and counting our the money. The procedures are more appropriate in the days of the Penny Black than to an institu- tion that is now loading the world in such high-tech oology fields as Viewdata. From the outside, one would have though! And for working mothers in particular — who are more likely than stay-at-home wives to have their own bank accounts — the freedom from The need to traipse regularly to the Post Office would be a major boon. The Department of Social Security secs immense obstacles but it admitted this week that it has at least begun to study seriously the possibility of pay- ing the benefits by credit trans- fer where a mother so desiTes. The officials are also looking at the question of paying the Old Age Pension by credit trans- fer. The proportion of pen- sioners who bave bank accounts is lower than for the active population: No figures are available but the Department seems to fear that the savings to it later on would not com- pensate for the extra expenses early on. Two payment systems would involve a great deal of duplication of effort, the Depart- ment adds. But it is not as if the sums the Department is paying nui are small: The Depart- ment is pressing ahead with cninnilinc a report for ministers. But such a dogmatic view- point seems to assume that husbands and wives are con- stantly bickering over ihe house- keeping money. Any wife who is happy about the way the family's finances are shared out and does not agree that this view is typical will feel insulted that the Slate does nut allow her to make up her own mind on whether ihe money should be paid into a joint account Bankers feel that there may be one other reason why Social Security officials may be luke- warm about introducing credit transfers: But the cost of disposing of cash is a small price to pay for the extra convenience for mother and pensioners. The objective of the Allied Hambro Pacific Fund is to obtain long term capital growth by investing: It enables you to invest in Singapore, Malaysia and the Philippines Ji a ve offered considerable potential for economic growth. Now a number of countries in this area huve begun to achieve their potential, and in recent years have shown remarkable growth rates, often twice that of many major industrialised countries. Until a few years ago political instability in the area was a major deterrent to investment. But while there is some risk of recurring political disturbances, the political climate, particularly following China's policy of improving relations with its neighbours, now appears more stable. At the same time, there is now within this area a. Oriom Ovmm Couninm Svtiru Pacdtr 1-ld. Swim TropotOoi Lid. V Wimor Industrial Corn. Malayan Banking fifed. The objective is to maximise long-term capital growth; income is not a consideration. The improving prospects of the area have already been reflected in rising stock market values during this year. While we consider that the prospects for growth will continue, you should bear in mind tbat investment in these markets con be subject to substantial short-term fluctuations. We recommend therefore that an investment in the fund should form only part of a balanced portfolio. That having been said, the advantages of investing in South East Asian marked through an authorised unit trust are powerful indeed, in terms of simplicity, convenience and spread of risk. An investment in the fund should be regarded as a long-term one. Remember the price of units and the income from them may go down as well as up. You should also note that currency movements can significantly affect the value of your investment. How to invest Investment opportunity To take advantage of opportunities to invest in companies operating in this area of potential growth, and to avoid the pitfalls, the experience of full-time. The portfolio 'is currently heing invested in the shares of companies quoted or operating in Hong Kong. Singapore, Malaysia and the Philippines, including companies registered in London or elsewhere which. You will be allocated units to the full value of your remittance at the offer price ruling on receipt of your application. Units in the fund may also he acquired on a Tegular monthly basis. For further details complete and return the coupon below, ticking the appropriate box. Uni La may normally be bought and nofel on any Lw mrUnK to. SeUlnff units. RtcUMit oAn u. I wish to invest Sifegiunlf. Thr Trvrtoe u! Chorees- The offer nricr cvmnll. The charge is currently lS. Xtuun appltatlicBi is granted, umtholden fat the bail will be asked to approve the anffopnatemerease. J declare that I am over 18 sod am not resident outside the UK or other Scheduled Tern tones and that I am not acouinna die above units es the. If you ere unable to malic ihe residential declaration it should be deleted and the form lodged through your UK bank, stockbroker or solicitor. This Offer is not available to residents of the Republic of Ireland. The Director nf Fair Trading. Gordon Borrie. It is also satisfied with the new regulations for the control of insurance brokers. Here it feels that There is room for chanses to avoid the quick kill type of sales, by spreading the initial commission over. Results reveal RP is positively correlated with enamel thickness, negatively correlated with femoral length, but weakly associated with the rate of enamel secretion and osteocyte proliferation. These new data imply that a slower biorhythm predicts thicker enamel for children but shorter stature for adults. Our results develop the intra-specific HHO hypothesis suggesting that there is a common underlying systemic biorhythm that has a role in the final products of human enamel and bone growth. Dimensiones del crecimiento humano Human growth dimensions. Se enfocan, igualmente, aspectos del desarrollo afectivo de la persona y su sinergia con las dimensiones del crecimiento ya mencionadas. This paper, based on the findings of pedagogic anthropology, highlights the essential endlessness of the human person -who is always prone to "being more" as a person- and considers to what extent education can enhance human growth. The different stages of intellectual development are analyzed in some detail, emphasizing the critical sense and the adequate or inadequate ways of promoting such development through teaching. The paper also studies the essential domains of the person's moral growth and the possibility, necessity and legitimacy conditions of an explicitly moralizing assertive influence as well as the links between moral education and civic education. Likewise, aspects of the person's affective development and their synergy with the above mentioned growth domains are focused. Finally, some commentaries are made on the development of the religious domain and its educational importance. Hematopoietic growth factors and human acute leukemia. Nonphysiological expansion of the leukemic population is not due to escape from control by these factors. Proliferation in vitro of AML cells is dependent on the presence of one or several factors in most cases. The pattern of factor-dependency does not correlate with morphological criteria in individual cases, and may thus offer a new tool for classification of AML. Overproduction of undifferentiated cells is not due to abnormal expression of receptors for the stimulating factors acting at an immature level. Rather, autocrine secretion of early acting lymphokines maintains proliferation of the leukemic clone. When looking at causes of leukemic dysregulation, yet undefined inhibitors of differentiation probably are of equal importance as dysequilibrated stimulation by lymphokines. Autodecomposition of radiolabeled human growth hormone. Human growth hormone hGH was radiolabeled with I, using a gentle lactoperoxidase technique. The stability and decomposition products of this tracer were studied by frequent periodic analysis by Sephadex G chromatography on a long column. Monomeric I-hGH showed an exponential decline, with a half-life of 61 days. The main radioactive degradation product was iodide, which appeared with a fractional appearance rate of 0. Secondary degradation products were a series of radioactive oligomers of hGH, which appeared with an overall fractional rate of 0. The kinetic data obtained should provide guidelines for the shelf-life and repurification schedule of radioiodinated polypeptides. Does It Slow Aging? Healthy Lifestyle Healthy aging Human growth hormone is described by some as the key to slowing the aging process. Before you sign up, get the Full Text Available The link between human capital and economic growth still remains unexplained because of the measurement issues connected to the human capital stock. This study investigates the link between human capital stock and economic growth using inclusive wealth index and ratio of engaged to actively disengaged employees as proxy for human capital stock. Data from the global workplace and inclusive wealth reports are used in order to provide an international comparison of the link between human capital and inclusive wealth. Cross country comparison show human capital largerly contribute to the inclusive wealth formation. Formal education is important but also motivating working environment is needed to achieve sustainable economic growth. The finding further indicates that standard human capital growth model should be revised taking into the account variables addressing sustainable growth not just growth and environmental variables work conditions affecting human capital stock. Countries encouraging investments in the development of individuals both through formal education and inspiring work environments achieve higher sustainable economic growth. Why higher economic growth cannot always enhance human development. This paper studies why higher economic growth cannot always enhance human development. In general, these two dimensions have a strong and positive relationship, but some countries appear unable to balance this relationship. As a consequence, there are some countries with high economic growth but sluggish human development progress. This paper studies how other factors besides GDP — women labor force participation, urbanization, and inequality - are correlated to human development. I construct Law, Economic Growth and Human Development: Evidence from Africa. This paper cuts adrift the mainstream approach to the legal-origins debate on the law- growth nexus by integrating both overall economic and human components in our understanding of how regulation quality and the rule of law lie at the heart of economic and inequality adjusted human developments. Findings summarily reveal that legal-origin does not explain economic growth and human development beyond the mechanisms of law. Our results support the current consensus that, English common-law coun The evaluation of clinical and analytical parameters as predictors of the final growth response in Turner syndrome patients treated with growth hormone. A retrospective study was performed on 25 girls with Turner syndrome 17 treated with growth hormone , followed-up until adult height. Auxological, analytical, genetic and pharmacological parameters were collected. A descriptive and analytical study was conducted to evaluate short 12 months and long term response to treatment with growth hormone. A favourable treatment response was shown during the first year of treatment in terms of height velocity gain in A favourable long-term treatment response was also observed in terms of adult height, which increased by Predictors of good response to growth hormone treatment are: A initial growth hormone dose, B time on growth hormone treatment until starting oestrogen therapy, C increased IGF1 and IGFBP-3 levels in the first year of treatment, and D height gain velocity in the first year of treatment. All rights reserved. Financing Human Development for Sectorial Growth: A Time Series Analysis. Full Text Available The role which financing human development plays in fostering the sectorial growth of an economy cannot be undermined. It is a key instrument which can be utilized to alleviate poverty, create employment and ensure the sustenance of economic growth and development. Thus financing human development for sectorial growth has taken the center stage of economic growth and development strategies in most countries. In a constructive effort to examine the in-depth relationship between the variables in the Nigerian space, this paper provides evidence on the impact of financing human development and sectorial growth in Nigeria between and , using the Johansen co-integration techniques to test for co-integration among the variables and the Vector Error Correction Model VECM to ascertain the speed of adjustment of the variables to their long run equilibrium position. The analysis shows that a long and short run relationship exists between financing human capital development and sectorial growth during the period reviewed. Therefore, the paper argues that for an active foundation for sustainable sectorial growth and development, financing human capital development across each unit is urgently required through increased budgetary allocation for both health and educational sectors since they are key components of human capital development in a nation. Human growth hormone alters carbohydrate storage in blood and Jun 2, Key words: Human growth hormone, blood glucose, hepatic glycogen, hypoglycaemia, Beyond Correlations. Empirical evidence on three assertions commonly-made by population policy advocates about the relationships among population growth , human capital formation and economic development is discussed and evaluated in the light of economic-biological models of household behavior and of its relevance to population policy. The three assertions are that a population growth and human capital investments jointly reflect and respond to changes in the economic environment, b larger families directly i It has often been reported that human capital, along with other growth enablers, has played an important role in this…. Innovation and the growth of human population. Biodiversity is sustained by and is essential to the services that ecosystems provide. Different species would use these services in different ways, or adaptive strategies, which are sustained in time by continuous innovations. Using this framework, we postulate a model for a biological species Homo sapiens in a finite world where innovations, aimed at increasing the flux of ecosystem services a measure of habitat quality , increase with population size, and have positive effects on the generation of new innovations positive feedback as well as costs in terms of negatively affecting the provision of ecosystem services. We applied this model to human populations, where technological innovations are driven by cumulative cultural evolution. Among them, the human population can fill the entire planet while maximizing their well-being, but not exhaust ecosystem services. However, this outcome requires positive or green technologies that increase the provision of ecosystem services with few negative externalities or environmental costs, and that have a strong positive feedback in generating new technologies of the same kind. If the feedback is small, then the technological stock can collapse together with the human population. Scenarios where technological innovations generate net negative impacts may be associated with a limited technological stock as well as a limited human population at equilibrium and the potential for collapse. The only way to fill the planet with humans under this scenario of negative technologies is by reducing the technological stock to a minimum. Otherwise, the only feasible equilibrium is associated with population collapse. Our model points out that technological innovations per se may not help humans to grow and dominate the planet. Purification and cultivation of human pituitary growth hormone secreting cells. Efforts were directed towards maintenance of actively secreting human pituitary growth hormone cells somatotrophs in vitro. The production of human growth hormone hGH by this means would be of benefit for the treatment of certain human hypopituitary diseases such as dwarfism. One of the primary approaches was the testing of agents which may logically be expected to increase hGH release. The progress towards this goal is summarized. Results from preliminary experiments dealing with electrophoresis of pituitary cell for the purpose of somatotroph separation are described. Full Text Available This article studies the controversial relationship between human capital and growth through different channels using a cross-country panel approach applied for countries, including 79 developing countries and 25 developed countries OECD during The analysis yields important insights into the relationship between human capital and growth. Firstly, we find a significant relationship between high levels of human capital and technology adoption Secondly, considering the levels of human capital directly as a innovation component in the productivity function shows that there is a non-linear relationship between this factor and growth. The results provide a new understanding of this relationship and to some extent contradict some earlier studies. Immunolocalization of transforming growth factor alpha in normal human tissues. Later, its immunohistochemical presence in normal human cells as well as its biological effects in normal human tissues have been demonstrated. The aim of the present investigation was to elucidate Indirect immunoenzymatic staining methods were used. The polypeptide was detected with a polyclonal as well as a monoclonal antibody. The polyclonal and monoclonal antibodies demonstrated almost identical immunoreactivity. In epithelial cells, three different kinds of staining patterns were observed, either diffuse cytoplasmic, cytoplasmic in the basal parts of the cells, or distinctly In this article, we define specific general human capital in terms of the occupations whose use is spread in a limited wide set of industries. We analyze the growth impact of an economy's composition of specific and general human capital, in a model where education and research and development are costly and complementary activities. The model suggests that a declining share of specific human capital, as observed in the Czech Republic, can be associated with a lower rate of long-term grow The effects of human resource practices on firm growth. Full Text Available Although the connection between firm growth and labour is well documented in economics literature, only recently the link between human resources HR and firm growth has attracted the interest of researchers. This study aims to assess the extent, if any, to which, specific HR practices may contribute to firm growth. We review a rich literature on the links between firm performance and the following HR practices: We surveyed HR managers and recorded their perceptions about the links between HR practices and firm growth. Results demonstrated that compensation policy was the strongest predictor of sales growth. Results provide overall support for all HR practices except of job security. Eventually, selecting, training, and rewarding employees as well as giving them the power to decide for the benefit of their firm, contribute significantly to firm growth. Quinones are growth factors for the human gut microbiota. The human gut microbiome has been linked to numerous components of health and disease. Previously, we found that growing environmental bacteria in situ in a diffusion chamber enables growth of uncultured species, suggesting the existence of growth factors in the natural environment not found in traditional cultivation media. One source of growth factors proved to be neighboring bacteria, and by using co-culture, we isolated previously uncultured organisms from the marine environment and identified siderophores as a major class of bacterial growth factors. Here, we employ similar co-culture techniques to grow bacteria from the human gut microbiome and identify novel growth factors. By testing dependence of slow-growing colonies on faster-growing neighboring bacteria in a co-culture assay, eight taxonomically diverse pairs of bacteria were identified, in which an "induced" isolate formed a gradient of growth around a cultivatable "helper. KLEbelonging to the anti-inflammatory Faecalibacterium genus-and Sutterella sp. While multiple helper strains were identified, Escherichia coli was also capable of promoting growth of all induced isolates. Screening a knockout library of E. KLE and other induced isolates. Our data show that menaquinones are a major class of growth factors for bacteria. Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor. The maximal stimulation of DNA synthesis 2. HGF may play an important role in epidermal tissue repair as it enhances both the migration and growth of keratinocytes. Elias, Elias G. Cytokines and growth factors have biologic effects that could stimulate tumor growth , invasion and angiogenesis. The incidence of 24 factors was investigated in 25 cultured human melanoma cell lines and in 62 fixed tissues at different stages of the disease. Illustrating the complexity of the milieu of the tumor microenvironment, some of these factors may have to be considered in targeted therapy. Full Text Available Cytokines and growth factors have biologic effects that could stimulate tumor growth , invasion and angiogenesis. Population growth , human development, and deforestation in biodiversity hotspots. Human population and development activities affect the rate of deforestation in biodiversity hotspots. We quantified the effect of human population growth and development on rates of deforestation and analyzed the relationship between these causal factors in the s and s. We compared the averages of population growth , human development index HDI, which measures income, health, and education , and deforestation rate and computed correlations among these variables for countries that contain biodiversity hotspots. When population growth was high and HDI was low there was a high rate of deforestation, but when HDI was high, rate of deforestation was low, despite high population growth. The correlation among variables was significant for the s but not for the s. The relationship between population growth and HDI had a regional pattern that reflected the historical process of development. Based on the changes in HDI and deforestation rate over time, we identified two drivers of deforestation: Policy choices that disregard conservation may cause the loss of forests even in countries that are relatively developed. Lack of development in other countries, on the other hand, may increase the pressure on forests to meet the basic needs of the human population. Deforestation resulting from policy choices may be easier to fix than deforestation arising from human development constraints. To prevent deforestation in the countries that have such constraints, transfer of material and intellectual resources from developed countries may be needed. Popular interest in sustainable development in developed countries can facilitate the transfer of these resources. Maternal serum placental growth hormone, but not human placental lactogen or insulin growth factor-1, is positively associated with fetal growth in the first half of pregnancy. To investigate if maternal levels of human placental lactogen hPL , placental growth hormone PGH and insulin-like growth factor-1 IGF-1 are associated with growth rate of the biparietal diameter BPD in the first half of pregnancy Pattern of hormone receptors and human epidermal growth factor Breast cancer is the most common cancer among women globally. Specific and general human capital in an endogenous growth model. AH - Economic s Impact factor: Full Text Available To understand how microtubules contribute to the dynamic reorganization of the endothelial cell EC cytoskeleton, we established an EC model expressing EB3-GFP, a protein that marks microtubule plus-ends. Using this model, we were able to measure microtubule growth rate at the centrosome region and near the cell periphery of a single human EC and in the EC monolayer. We demonstrate that the majority of microtubules in EC are dynamic, the growth rate of their plus-ends is highest in the internal cytoplasm, in the region of the centrosome. Growth rate of microtubule plus-ends decreases from the cell center toward the periphery. Our data suggest the existing mechanism s of local regulation of microtubule plus-ends growth in EC. Microtubule growth rate in the internal cytoplasm of EC in the monolayer is lower than that of single EC suggesting the regulatory effect of cell-cell contacts. Our results indicate functional interactions between cell-cell contacts and microtubules. ITE inhibits growth of human pulmonary artery endothelial cells. Current therapies primarily aim at promoting vasodilation, which only ameliorates clinical symptoms without a cure. However, the roles of ITE in human lung endothelial cells remain elusive. Herein, we tested a hypothesis that ITE inhibits growth of human pulmonary artery endothelial cells via AhR. Immunohistochemistry was performed to localize AhR expression in human lung tissues. Immunohistochemistry revealed that AhR was present in human lung tissues, primarily in endothelial and smooth muscle cells of pulmonary veins and arteries, as well as in bronchial and alveolar sac epithelia. Triparanol suppresses human tumor growth in vitro and in vivo. Black-Right-Pointing-Pointer Demonstrate Triparanol can block proliferation in multiple cancer cells. Black-Right-Pointing-Pointer Demonstrated Triparanol can impede tumor growth in vivo in mouse xenograft model. Despite the improved contemporary multidisciplinary regimens treating cancer, majority of cancer patients still suffer from adverse effects and relapse, therefore posing a significant challenge to uncover more efficacious molecular therapeutics targeting signaling pathways central to tumorigenesis. Here, our study have demonstrated that Triparanol, a cholesterol synthesis inhibitor, can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol. Remarkably, we have proved Triparanol can significantly repress Hedgehog pathway signaling in these human cancer cells. Furthermore, study in a mouse xenograft model of human lung cancer has validated that Triparanol can impede tumor growth in vivo. We have therefore uncovered Triparanol as potential new cancer therapeutic in treating multiple types of human cancers with deregulated Hedgehog signaling. Numerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known. To identify genes controlling glioma invasion, we used genome-wide mRNA expression profiles of primary human glioblastomas to develop an expression-based rank ordering of 30 transcription factors that have previously been implicated in the regulation of invasion and metastasis in cancer. SNAI2 mRNA expression correlated with histologic grade and invasive phenotype in primary human glioma specimens, and was induced by EGF receptor activation in human glioblastoma cells. Surface-bounded growth modeling applied to human mandibles. This thesis presents mathematical and computational techniques for three dimensional growth modeling applied to human mandibles. The longitudinal shape changes make the mandible a complex bone. The teeth erupt and the condylar processes change direction, from pointing predominantly backward A local shape feature called crest line has shown itself to be structurally stable on mandibles. Registration of crest lines from different mandibles results in a sparse deformation field, which must be interpolated When using successively more recent scans as basis for the model the error drops to 2. Thus, it seems reasonable to assume that the mandibular growth is linear Human pituitary and placental hormones control human insulin-like growth factor II secretion in human granulosa cells. Human granulosa cells cultured with calf serum actively proliferated for generations and secreted progesterone into the medium; progesterone levels appeared to decline with increase in generation number. The progesterone secretion was enhanced by the addition of human follitropin, lutropin, and chorionic gonadotropin but not by growth hormone. These cells, when challenged to varying concentrations of human growth hormone, human chorionic somatomammotropin, human prolactin, chorionic gonadotropin, follitropin, and lutropin, secreted IGF-II into the medium as measured by specific IGF-II RIA. Among these human hormones, chorionic gonadotropin, follitropin, and lutropin were most effective in inducing IGF-II secretion from these cells. The results described suggest that cultured human granulosa cells can proliferate and actively secrete progesterone and IGF-II into the medium. IGF-II production in human granulosa cells was influenced by a multi-hormonal complex including human growth hormone, human chorionic somatomammotropin, and prolactin. Purification of human platelet-derived growth factor. The paper describes a method for purification of human platelet-derived growth factor PDGF from outdated platelet-rich plasma PRP using commonly available laboratory reagents and yielding a mitogen purified ,fold over the starting material. Other assays to quantitate PDGF include radioreceptor assay and radioimmunoassay. Gold thread implantation promotes hair growth in human and mice. Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When embedded into the depilated Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Objective Dysregulation of WNT signaling plays a central role in tumor cell growth and progression. Design Prospective study of human leiomyoma cells obtained from myomectomy or hysterectomy. Setting University research laboratory. Our findings provide rationale for further preclinical and clinical evaluation of ICAT, niclosamide, and XAV as candidate anti-tumor agents for uterine leiomyoma. B r E nioim day. Sheldon brought a flood of applications from companies tickets for their Yesterday British Rail said that the statement accelerated a process which started about three! Plans are already being creases. Sir Geoffrey Howe, month. Conservative earlier thLs i. He made it clear, however, that he believed Arm. He preferred to stress freedom from government inicrferenci? John Paraue. Pardoe said Britain had 1 1 pea n bu- again. Lf we did not join Government in a difficult uur partners iu the system in linn. A Commons debale the New Year we would be been promised on the Euro- forced sooner or later to accept a Monetary System when a a i-mninan currency fashioned by siun is taken in December others. John Collins, managing director of Park West Motors, [ford. Essex, which imports Toyota cars, was delighted, if not a little surprised, by ihe news of ihe loan which will enable him lo buy xi new garage and. The corporation was 3 little coy about the deal. This, departure mla imports financing was iustjfled largely on the hasis of Mr. Collins be-. Collins did nut import Tuyotas. It said: Coilins said that when he applied for the loan he had expected the nature of hfs trade to be a problem. Finance had been difficult to find, but. Peter Foden-Pattin-: Conservative sun. Minet Agencies, and for Thanei East, about the Mr. Confidence was also expressed m Mr. Bernard Wex. The dispute over productivity is to be ihe subject of talks with Mr. It has also been the cause of warnings by the construction company that if payments con- tinue- to he withheld it might be forced to abandon the pro- ject, which. British Bridge Builders ruled twu weeks ago that if the Free- man Fox targets were not met the cable spinners would lose bonus payments equivalent lo about one third of weekly earnings. Haydon Glen, clerk to the Board, said that outstanding issues in the dispute would have to be- settled by arbitration or in the High Court. British Industry indicated last The campaign was formed in night that ii took seriously pro- response to a Labour document, posals by sections of the Labour suggesting a National Construc- Party for nationalisation of the tion Corporation on the lines of building industry. Erie Heffer, thai Labour should argue for step-by-slep public ownership of the construction industry. However, the Labour Party planned nationalisation. Water workers. The employer f had to provide the season ticket years ago and most annual sea- son tickets were now bought. Lins it Dispute delays frigate launch which would not be cashable by the employee, and he could not reimburse him for a ticket already bought. The frigate represent a key public sector Brilliant was to have been group in the low-pay area which launched next week. British Finally, the employee's earn- Mr. The Inland Revenue said yesterday that additional qualifi- cations. And it was likely most of the Discussion ranged round im- proving productivity by natural wastage. The management is stilt seeking to reduce the labour force by several thousand. Talks on this are At yesterday's meeting of Iho expected to take weks. The question of what cate- gories of workers make up ihe grades — and their rates — has stili not been settled. Saturday night shift, it added. Heffer was ownership, as the TUC had pru- addressmg. TASS, the engineering sluff union, yesterday issued a strong denial of charges reported to have been made last weekend by Mr. Michael Edwardes. BL chairman. TASS national lift. He Is ton. Rudolph Agnew, deputy chairman, said yesterday that the study would be finished in a matter of weeks. The venture would be on a small scale, producing less than half the amount of tin -of Wheal Jane, near Truro. Wheal Jane had an output of That mine is now on a care- and-malatenance basts after production. Robert L. Sprinkel— bis reluctance to accept Government money and the fact that he is willing tu put his own money ih, H Said Lord Erroll of Hale, the ehairman. Bat he held to the basic Gold Fields position on Wheal Jane: Bnt Lord Errol! As far as other Cornish activities are concerned,. Gold Fields is evaluating the results of drilling at two neglhbonring sites. ICI said yesterday that it did not yet have firm plans for the site, but it could follow the pattern of its biggest petro- chemicals site at Wilton on Teeiside. Products could include ammo nia and methanol— derived from natural gas — as wel-1 as oiher basic petrochemicals and down- stream products such as plasucs and fibres. It is also involved in exploration pro grammes on various parts of the UK continental shelf In the North Sea and to the west oF the Shetlands. It has developed more than 1. Il is thought however, that ICI is anxious not to concentrate its resources too heavily In one area. It has carried out land and seabed surveys at an estuary site in Tayside, Scotland. The site is at Barry Buddon. The company is also under stood to have investigated the Humber estuary in England. Both the Humber and Tay offer sites with fiat land and access to. The com puny has held a series of dis- cussions with the Scottish Office shout the Tayside location. First news of the plan has already brought mixed reactions from local interests on Tayside. Dundee has high unemployment It might therefore be expected 3 hili 1 in spa,n - The deposit certificates trial. He was jointly charged. Felicio Morelia, the former Banking Corporation and its head of both international Bank, associated company, European ing and European and Arabian, and Arabian Bank, both regis- who was jailed for three years tered in Anquilia. Unterlaggauer has prison sentence at the Old Bailey, spent 12 months in custody, he Dr. Heinrich Peter Unlertag- will be released on Honda when gauer, born In Austria, had a riepnrtatinn order will be con- pleaded guilty to charges of issu- sirlcrert. He claims io have a ing false certificates of deposit job awaiting him in Germany, in order to acquire seven hotels Mr. Joseph Khalife is still on in Spain. The deposit certificates trial. He Detective Chier Inspector Roy has pleaded no't guilty-. Elsey, he admitted signing 15 European and Arabian Bank certificates — together with has no connection with the another former employee of European Arab Bank group International Banking Corpora- Industrial Banking Cornoration" non who has since left the UK. Uo terlaggauer's sentence the c ame name. EG Commission to make their eipalities: Most of the steel in an average British car body is sheet steel. There was little to cheer in the silt market either, as a further rise in U. Interest rates British interest rates are still high enough to attract inflows from the United States, even after the most recent rise in the U. As the forward discount on ster- ling has shrunk almost to par. On a simpler level, it does seem that confidence in sterling, as against lack of confidence in the dollar, has been growing over the last week, with the foreign exchange markets appealing rather less worried about news on the labour front. There has been some nervous- ness i hat the Bank of England might intervene to stop sterling rising fun her. Next week the official cur- rency reserve figures for October will be published, and they are expected to show that the Bank's intervention has been limited. But any sign aF funds flowing heavily into London could be worrying to the markets, unless of course foreign money flows into gilts and encourages the home-based institutions tu jump in too. At the moment, though, short money rates are so high that they weaken the inducement to commit money to gilts. Drug problems Beecham's share price took a rumble last week on news that the company may bo forced to cut its drug prices further in the U. Analysts, on lie other hand, feel the market reaction may be somewhat overdone. The issues arc undoubtedly complex and involve a fair bit of unfinished litigation. Beecham, for example, is still suing its main U. But Bristol and Beecham have both been on the receiving end under U. It comes, moreover, in the wake of average amoxy- cillin price cuts since July of roughly 20 per cent. This has already been noted by dose ob- servers of the U. In the short term, despite some loss in market share. Although longer term growth prospects from the U. After sliced bread Now that the loss-making bread baking business is out of the way. A 98 Offer from Wm. Baird lapsed De Beers Dfd. Group Financial Gp. So loss elimination should be worth Elsewhere the milling division did better, and grocery products and meat are singled out as having done well. The one question for the market is haw quickly Spillers will restore its dividead. Last year when profits collapsed the dividend was slashed from 2. The market is banking on Spillers going some way to restoring the divi- dend this year. For the whole of last year losses in the U. This left group profits only. The problems seem to have been twofold. First, Mothercare j set up its U. The bulk of these were under 1. Secondly, the Mothercare management in the U. Strenuous efforts, including top management changes, are now going on to turn the pro- ject round. And meanwhile the stores operating under the Mothercare name are apparently doing well. Impressive though ' the Dow's losses have been in the last two weeks, they in fact understate the broad market decline, notably the routing of secondary stocks. The American Stock Exchange which hosts many' of the smaller, less capitalised companies, has seen its index tumble by a formidable 17 per cent front its peak in mid- September, while the Dow has suffered a more modest 9. On Thursday the Dow drew back by 9. But yesterday the decline quickened and the Dow dropped Technical analysts looking for a rainbow claim they are only mildly surprised at the slaughter. They point out that before the rally which started last April the market bad been seriously weakened by the Blue Chips — the IB Ms and Polaroid; of this world — while the smaller stocks had shown positive strength for most of last year. Meanwhile, away from the technicians' charts investors have found that the world is too much with them. In a brief but grisly recap the week's news has included a rise in commercial hanking prime rates to per cent, the. A 19th-century Russian novelist would have been strained to write a more depressing scenario There is as much scepticism in the U. Somewhat curiously there has been no attempt berc to cite the achievements of Britain's voluntary policy in justification for the new approach when on the surface the prospects for success are at least as good as they were in Britain. When they have been at their most negative they have simply assumed that conditions have been so bad. Perhaps the time has come again to search for a new meta- phor. The latest batch of quarterly results from North American groups show- a dis- tinct improvement over a year ago, if not in profits at least in sales. It is tempting to see the figures as the definite start nf a new trend, but the U. Another of the U. It came back into Ihe black in the second quarter and in the three months to No. The said Minute is in lhe wordsand figures following: Charles Barber, the Asarco chairman. Tm iD the same three mouths of Although zinc prices hafe been at lower levels than last year, lead demand has been strong and looks like remaining so. Further evidence nf the revival in the copper industry came from Freeport Minerals, whose profits in the September quarter jumped sharply to S7. In contrast the market for tin has been consistently strong. But this bas not provoked any consistent rise in Malaysian production, as the accamsnyiaz fable shows. A combination of higher taxes ami. Sprinkel publicly to disclose his intention of try- ing to put together a financial package allowing him to take- over the Wheal Jane tin mine in Cornwall. Sprinkel is an American entrepreneur, now resident in Derbyshire, and within the next two weeks he hopes to make Consolidated Gold Fields, the present owners, a definite offer. Ayer Hitam - Be r junta! Piran — Far East St. Piran— UK South Crafty Southern Malayan Tanjong Tong kah Harbour 42 40 Tronoh i Figures hi elude low-grade material f Not yet a puts are shown in metric tonnes of tin concentrates. Sept, Atut. Another metal which has strengthened its price despite the recession is molybdenum. A in ax. This level was reached four months before bullion peaked ar SI Political factors arc one reason for the poor general per- formance of golds. A good ex- ample of the short-term effects arose last week, during the visit of the five western foreign ministers to Pretoria. On tiie Wednesday, the gold price hit a new record las it then was of S Politics, however. Mine violence has died down, the mine- have obtained a better spread of labour, which five years ago ua. One overriding reason for the low level of interest in golds is ihe growth of ihe gold furures markets in the U. In these markets did not exist and physical gold ownership was only authorised early in So gold shares — U. Wnn trading in the U. This aside. The table shows U. The top 15 account for R5. However, the table shows the U. In addition to U. There has also been a massive flow of De Beers shares to the U. Johannesburg brokers estimate 10 per cent of De Beers is now held in the U. Except to the U. With the local institutions traditionally more interested in industrials than golds and the European investor virtually out nf the market for a mixture of political and financial. But the counter- pull of the future markets and the high existing level of U. Gcfinlrl 45 Western Holds. Brand 24 66 Pres. Totals 5, Tx Gar t m ore Fmxl Managers Lid. Eamonn Fingleton iks at ways to cut the cost. But unless you are care- you will lose about T per of your capital in dealing ; every time you switch, point is thai the dealing of a switch is often the difference between the r" price at which unit: He needs to choose a? Jives tors who get into units. These can he useful when the outlook for shares turns choppy. With some groups— Hambro. First switch free. Cutting the bother of Child Benefits ing in various types of equities Some unscrupulous brokers for bond investors. Barclays have been criticised recently for Unicorn bondholders cannot drumming up commission by link their investment to any encouraging unnecessary switch- particular unit trust but instead ing. Such brokers are unlikely it is put in a managed fund invested in a selection of the group's trusts. The managers vary the mix as market conditions dictate. Barclays, for instance, usually deducts in full the amount of any commis- for cent initial commission introducing new business. Indications for the second and third weeks arc that sales are lower, bill still very strong. The sudden sales surge re- flects the fact that -from October 1. Yet this jump in sales no- where near represents the full potential that could have taken place. There are about lira persons holding these certifi- cates, of whom over lm held the maximum holding before October 1. Looking to the immediate future' and the likely movement in the Retail Price Index, the official forecasts are that the year-on-year increase will re- main around S per cent for the next six months. But unofficial forecasts of r the rise of the RPI in the next 12 months vary from 6 to 12 per cent depending on the view on forthcoming wase settlements. Stockbrokers Phillips anti Drew, for example, is forecasting an They have lo watch patiently as the assistant goes through the palaver of stamping the benefit book, removing a counterfoil and counting our the money. The procedures are more appropriate in the days of the Penny Black than to an institu- tion that is now loading the world in such high-tech oology fields as Viewdata. From the outside, one would have though! And for working mothers in particular — who are more likely than stay-at-home wives to have their own bank accounts — the freedom from The need to traipse regularly to the Post Office would be a major boon. The Department of Social Security secs immense obstacles but it admitted this week that it has at least begun to study seriously the possibility of pay- ing the benefits by credit trans- fer where a mother so desiTes. The officials are also looking at the question of paying the Old Age Pension by credit trans- fer. The proportion of pen- sioners who bave bank accounts is lower than for the active population: No figures are available but the Department seems to fear that the savings to it later on would not com- pensate for the extra expenses early on. Two payment systems would involve a great deal of duplication of effort, the Depart- ment adds. But it is not as if the sums the Department is paying nui are small: The Depart- ment is pressing ahead with cninnilinc a report for ministers. But such a dogmatic view- point seems to assume that husbands and wives are con- stantly bickering over ihe house- keeping money. Any wife who is happy about the way the family's finances are shared out and does not agree that this view is typical will feel insulted that the Slate does nut allow her to make up her own mind on whether ihe money should be paid into a joint account Bankers feel that there may be one other reason why Social Security officials may be luke- warm about introducing credit transfers: But the cost of disposing of cash is a small price to pay for the extra convenience for mother and pensioners. The objective of the Allied Hambro Pacific Fund is to obtain long term capital growth by investing: It enables you to invest in Singapore, Malaysia and the Philippines Ji a ve offered considerable potential for economic growth. Now a number of countries in this area huve begun to achieve their potential, and in recent years have shown remarkable growth rates, often twice that of many major industrialised countries. Until a few years ago political instability in the area was a major deterrent to investment. But while there is some risk of recurring political disturbances, the political climate, particularly following China's policy of improving relations with its neighbours, now appears more stable. At the same time, there is now within this area a. Oriom Ovmm Couninm Svtiru Pacdtr 1-ld. Swim TropotOoi Lid. V Wimor Industrial Corn. Malayan Banking fifed. The objective is to maximise long-term capital growth; income is not a consideration. The improving prospects of the area have already been reflected in rising stock market values during this year. While we consider that the prospects for growth will continue, you should bear in mind tbat investment in these markets con be subject to substantial short-term fluctuations. We recommend therefore that an investment in the fund should form only part of a balanced portfolio. That having been said, the advantages of investing in South East Asian marked through an authorised unit trust are powerful indeed, in terms of simplicity, convenience and spread of risk. An investment in the fund should be regarded as a long-term one. Remember the price of units and the income from them may go down as well as up. You should also note that currency movements can significantly affect the value of your investment. How to invest Investment opportunity To take advantage of opportunities to invest in companies operating in this area of potential growth, and to avoid the pitfalls, the experience of full-time. The portfolio 'is currently heing invested in the shares of companies quoted or operating in Hong Kong. Singapore, Malaysia and the Philippines, including companies registered in London or elsewhere which. You will be allocated units to the full value of your remittance at the offer price ruling on receipt of your application. Units in the fund may also he acquired on a Tegular monthly basis. For further details complete and return the coupon below, ticking the appropriate box. Uni La may normally be bought and nofel on any Lw mrUnK to. SeUlnff units. RtcUMit oAn u. I wish to invest Sifegiunlf. Thr Trvrtoe u! Chorees- The offer nricr cvmnll. The charge is currently lS. Xtuun appltatlicBi is granted, umtholden fat the bail will be asked to approve the anffopnatemerease. J declare that I am over 18 sod am not resident outside the UK or other Scheduled Tern tones and that I am not acouinna die above units es the. If you ere unable to malic ihe residential declaration it should be deleted and the form lodged through your UK bank, stockbroker or solicitor. This Offer is not available to residents of the Republic of Ireland. The Director nf Fair Trading. Gordon Borrie. It is also satisfied with the new regulations for the control of insurance brokers. Here it feels that There is room for chanses to avoid the quick kill type of sales, by spreading the initial commission over. The Department of Trade has been pursuing this same line with the LOA, which up tu nuw has adupted an air that all is well..

It was shown that EGF contents in pancreatic carcinomas were significantly higher than those in normal pancreas or benign pancreatic tumors. EGF was also detected in the culture medium of Rin aoki porn etotic clips pancreatic carcinoma cell line.

The binding of I-EGF to the pancreatic carcinoma cells was time and temperature dependent, reversible, competitive, and specific. Scatchard analysis showed that the dissociation constant of EGF receptor was 2. Human milk fortification strategies for improved in-hospital growth of Human milk is the preferred feed for preterm infants, Rin aoki porn etotic clips it may need to be fortified for optimal growth and development.

Standard fortification of Rin aoki porn etotic clips milk seldom meets the recommended intake of protein, leading to inadequate post-natal growth. This article aims to critically review different human milk fortification Developmental regulation of human truncated nerve growth factor receptor. DiStefano, P. Urine samples were collected from 70 neurologically normal subjects ranging in age from 1 month to 68 years. By using Rin aoki porn etotic clips sensitive two-site radiometric immunosorbent assay, NGF-Rt levels were found to be highest in urine from 1-month old subjects.

No evidence for diurnal variation of adult NGF-Rt was apparent. Pregnant women in their third trimester showed Rin aoki porn etotic clips elevated urine NGF-Rt values compared with age-matched normals. These data show that NGF-Rt is developmentally regulated in human urine, and are discussed in relation to the development and maturation of the peripheral nervous system.

Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Human papilloma virus HPV types 16 and 18 are most commonly associated with cervical carcinoma Rin aoki porn etotic clips patients and induce immortalization of human keratinocytes Rin aoki porn etotic clips culture.

Rin aoki porn etotic clips has not been associated with breast cancer. This report describes the immortalization of normal human mammary epithelial cells 76N by plasmid pHPV18 or pHPV16, each containing the linearized Rin aoki porn etotic clips genome. Transfectants were grown continuously for more than 60 passages, whereas 76N cells senesce after passages.

The transfectants also differ from 76N cells in cloning in a completely defined medium called D2 and growing a minimally supplemented defined medium D3 containing epidermal growth factor.

HPV transfectants do not form tumors in a nude mouse assay. It is concluded that products of the HPV genome Rin aoki porn etotic clips immortalization of human breast epithelial cells and reduce Smooth twink growth factor requirements. This result raises the possibility that HPV might be involved in breast cancer. Furthermore, other tissue-specific primary epithelial cells that are presently difficult to grown and investigate may also be immortalized by HPV.

Expression of the human growth hormone variant gene in Rin aoki porn etotic clips fibroblasts and transgenic mice.

The nucleotide sequence of the human growth hormone variant gene, one of the five members of the growth hormone gene family, predicts that it encodes a growth hormone-like protein. The growth hormone variant protein expressed in transiently transfected L cells is distinct from growth hormone itself with respect to reactivity with anti- growth hormone monoclonal antibodies, behavior during column chromatography, and isoelectric point.

Transgenic mice expressing the growth hormone variant protein are 1. Algorithmic complexity of growth hormone release in humans. Most hormones are secreted in an pulsatile rather than in a constant manner. This temporal pattern of pulsatile hormone release plays an important role in the regulation of cellular function and structure.

In healthy humans growth hormone GH secretion is characterized by distinct pulses whereas patients bearing a GH producing tumor accompanied with excessive secretion acromegaly exhibit a highly irregular pattern of GH release. It has been hypothesized that this highly disorderly pattern of GH release in acromegaly arises from random events in the GH-producing tumor under decreased normal control of GH secretion. Using a context-free grammar complexity measure algorithmic complexity in conjunction with random surrogate data sets we demonstrate that the temporal pattern of GH release in acromegaly is not significantly different from a variety of stochastic processes.

In contrast, normal subjects clearly exhibit deterministic structure in their temporal Rin aoki porn etotic clips of GH secretion. Our results support the hypothesis that GH release in acromegaly is due to random events in the GH-producing tumorous cells which might become independent from hypothalamic regulation.

Clinical impact of biotechnology has been constrained by the limitations of traditional hypodermic injection of biopharmaceuticals.

Microneedle patches have been proposed as a minimally invasive alternative. In this study, we assess the translation of a dissolving microneedle patch designed for simple, painless self-administration of biopharmacetucials that generates no sharp biohazardous waste. After manual insertion into the skin of hairless rats, hGH pharmacokinetics were similar to conventional subcutaneous injection.

After patch removal, the microneedles had almost completely dissolved, leaving behind only blunt stubs. The dissolving microneedle patch was well tolerated, causing only slight, transient erythema. This study suggests that a dissolving microneedle patch can deliver hGH and other biopharmaceuticals in a manner suitable for self-administration without sharp biohazardous waste.

Humanized versus murine anti- human epidermal growth factor receptor monoclonal antibodies for immunoscintigraphic studies. Morales, Alejo A. The mAb ior C5 that recognizes an antigen expressed preferentially on the surface of malignant and cytoplasm of normal colorectal cells was used as negative control.

Among all organs significant accumulation was found in tumor 6. The immunoreactive Rin aoki porn etotic clips were found to be 0.

Thus, we expect better results using the humanized mAb h-R3 for diagnostic immunoscintigraphy. The anti- human epidermal growth factor receptor EGF-R humanized antibody h-R3 IgG 1which binds to an extracellular domain of EGF-R, was used to evaluate the biodistribution on nude mice xenografted with A Rin aoki porn etotic clips carcinoma cell line. Immunoreactivity of 99m Tc-labeled mAbs was measured by enzyme linked immunosorbent assay on A cell line and the immunoreactive fractions determined by Lindmo method.

Full Text Available In order to address the direction of causality between human capital and productivity growth in Nigeria, the study first investigated the pattern of productivity growth in Nigeria between and Following the endogenous growth model, which argued that technical progress, through an effective labor force, could lead to long-run growth which can be determined from within an economy; but it actually depends on the Rin aoki porn etotic clips with which resources available to such an economy are utilized.

This is against the exogenous growth model which click here that long-run growth can be attained by some unexplained technological check this out, which is exogenous to any economy. Based on this controversy in literature, this study empirically determined the productivity growth in Nigeria, as well as the causal relation between human capital development and productivity growth in Nigeria using the Engle-Granger causality test.

The results revealed that productivity growth has been very low and unstable in Nigeria as it oscillated between In addition, the nexus between human capital and productivity growth was examined.

The findings revealed that while productivity growth caused human capital development, human capital development did not cause productivity growth. Metabolic clearance and production rates of human growth hormone. No difference was evident between sexes, or between various age groups.

Patients with acromegaly demonstrated normal MCR's. The MCR was relatively constant from day to day and within the day when subjects were evaluated in the supine position. These results were contrasted with the MCR of HGH observed in a Rin aoki porn etotic clips number of patients with altered thyroid function or diabetes mellitus.

As growth hormone possesses anabolic properties Rin aoki porn etotic clips are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I IGF-I its specific binding proteins Mathematical modelling of the growth of human fetus anatomical structures.

The goal of this study was to present a procedure that would enable mathematical analysis of the increase of linear sizes of human anatomical structures, estimate mathematical Rin aoki porn etotic clips parameters and evaluate their adequacy.

Section material consisted of 67 foetuses-rectus abdominis muscle and 75 foetuses- biceps femoris muscle. The following methods were incorporated to the study: Size changes can be described with a segmental-linear model or one-function model with accuracy adequate enough for clinical purposes.

The interdependence of size-age is described with many functions. However, the following functions are most often considered: The best adjustments to measurement results were observed in the exponential and Gompertz's models. The growth pattern of the Rin aoki porn etotic clips intestine and its mesentery.

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It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. Rin aoki porn etotic clips reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visualization techniques.

We distinguished 3 generations of midgut loops. The topography of primary and secondary loops was constant, but that of tertiary loops not. The orientation of the primary loop changed from sagittal to transverse due to the descent of ventral structures in a body with a still helical body axis. The 1st secondary loop duodenum, proximal jejunum developed intraabdominally towards a left-sided position.

The 2nd secondary loop distal jejunum assumed a left-sided position inside the hernia before returning, while the 3rd and 4th secondary loops retained Best girls on snapchat positions. Intestinal return into the abdomen Rin aoki porn etotic clips a backward sliding movement.

Only after return, the 4th secondary loop distal ileum, cecum rapidly "slid" into the right lower abdomen. The seemingly random position of the tertiary small-intestinal loops may have a biomechanical origin.

The interpretation of "intestinal rotation" as a mechanistic rather than a descriptive concept underlies much of the confusion accompanying the physiological herniation. We argue, instead, that the concept of "en-bloc rotation" of the developing midgut is a fallacy of schematic drawings.

Primary, secondary and tertiary loops arise in a hierarchical fashion. The predictable position and growth of secondary loops is pre-patterned and determines adult intestinal topography. We hypothesize based on published accounts that malrotations result from stunted development Rin aoki porn etotic clips secondary loops.

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Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis. Twenty consecutive patients with cirrhosis were randomized to recombinant human growth hormone Norditropin, 4 I.

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It looks to me quite difficult to do in that although the full-colour photograph 'Is printed on to the canvas there are no absolute directions over which colours to put where and bringing human features to life is not easy. Needlecraft, 60, Holmes dale Road. Teddington, Middlesex. Delivery is about four weeks. Make sure that the print you send is clear; jf necessary cut out irrelevant details in the background. The designs are all, naturally enough, on racing themes, and I suppose on the assumption that racing circles are well-heeled, the prices are not low. V V ViT. MOST of us tend to think that commissioning portraits or sculptures is the province of the very rich or of grand com- panies which want to honour their distinguished presidents. Not many people realise that it is easier, less daunting and Jess expensive than they might imagine to have carried out either a portrait or a sculpture of either themselves or some- body they are fond of. The most reasonable method that I know of unless you have access to an Impecunious and talented future Augustus John is through two organisations that specialise in sifting both artists and potential clients, thus eliminating all the embar- rassment of being face to face with an individual. The National Portraiture Association. Surrey, is a registered charity which uses its funds to support scholarships and it has thus persuaded about 50 distin- guished artists to contribute their services, at reduced fees, in order to benefit the charity. In the past he has designed gravestones, com- memorative plaques, alphabets, exhibition pieces, glass bowls and medals. The fees charged have varied very little since I last wrote about the association nearly four years ago and the method for initiating a commission is much the same. Anybody inter- ested in having a portrait done should write to the association,, at the address given above, enclosing a 9p stamp, and they will then receive a brochure listing all the fees and the different mediums available chalk, pastels, oils and so on. From the illustrations enclosed in the brochure the potential client chooses the kind of style that most suits his taste and from there he can proceed with a commission. They include some very illustrious names like Michael Noakes almost every member of the Royal Family seems to have sat for him. The only artist of whom X have personal experience is Frances Baruch who has just completed a head of my daughter photographed above. She works from home at 16 Clifton Hill, London. NWS, and she works very quickly — she likes between four and six sittings, arranged very close together. She has most recently sculpted one of Sir Georg Solti's children and many other eminent people besides. ALMOST all good-class stationery shops and department stores have an excellent selection of writing-paper with initials incorporated somewhere into the design. Harrods, too, have a good stationery department and this pack of 15 monogrammed note cards, each In cream and navy border with gold letter, is accompanied by cream envelopes lined with navy bine. They will also send by post for 55p extra. The Yeoman gate illustrated is one of our range of craftsman made timber gates, constructed to give prolonged service. Other attractive designs are also available for the garden or farm. Sond 7p far a brochure or vtait m u Blddenden. Height Avt, table in antique shades ot green, red tan or dark raw lor order lorm. Mainland appro,. They have both been Deraarc ation lines and union requests and disc shows with Mr. U tries to leave som p d ne Peter Witt. Everyone tends to do nausic-on-ta: It has. Studio Piano-sirurummg musicians who prT , duC4fd by Mr. Three Force John's have been associated for anthems and the Funeral Sc a few musical seasons now, gen- traces all dating from the co orally mixing ancient and mod- poser's early twenties or befor - ern with fine artistry but, one were preceded by music from t gathers, not too good a response previous generation with whi at the box office. Their new he would have been famil. George Jeffries' v: Osnabrfick, where with each other. Why not. Havms spent Much of the time the station is H US,? In this case. In Nottingham they are engaged on various multi-racial projects. In Derby they have ventured abroad to broadcast programmes from their twin town in Germany. Davis, Joyce Blair and Leonie Cosman. What Derby last Friday when I was the BBC alms to offer is the piere rated more than a few choice between listening to one inches in the national Press but of five services, four of them they were all of major lraport- Network Radios 1 to 41 and one ance to this community: Billy full-blown musical. Anthony directed by Kenneth Chub, at: Quayle, a tough old Lear, should dishonesty in human relat: Ushers Carlin Music who are It will have an all-American cast not be missed. Reviewed Wed- ships. Reviewed Friday. A group of is already arranged. Jesse and m the Rat! S usual here. Thursday, the Cot? Lunchthne hour Daunt. Could that be a about South African politics, set Outside central London, ths a headc air about the studios was a good morning for the Solution to Problem No. E ment as the sline and pebbles mine when a big national storv K-B5: K- about how their shows are musical's cause. Witt is other. The best one I ever made safest recommendation since the latest antics of The Petr. Battles have been fou"ht here breaks io the area. He aware that many British Jews, was as an agent Would you Sleuth. Hypnotic play bv ton: T u ae wnn! Not from Matt; 1 1 though there are many vana- refugee from Nazi Germany alter a long fight and the com- it might have been. When Jarvis Mr. Steve Kulukundist. Witt gave him ail j ded. Jason Ro bards. Lauren Mr. Win prefers to have pro- the appropriate assurances and, elude that the primary aim will sections. For Bacall and Eli Wallach. Football Focus Boxing 1. Motor Sport World Gymnastics Champion- ships t Wales — 8. Scotland — 1. Northern Ireland: Ulster v Connacht. BBC 2 j3. Elite Syncopations; Four Schumann Pieces. Tweedle- dum and Tweedledee: L55 Mind Your L-anguajca. US mm At be End of the Day. SJ0 The Blnmc Woman. US Doctor On the Go. IM0 Saturdar Cinema: OO am Doctor: ID JO Tlswas. UJ0 The Bionic Woman. U Streets of San Francisco. U 30 Logan's Run. Gale Storm. Walter Brennan and Vincent Price. I1J0 Sesame Street. S0 L'niamed World. L55 Mind Your Language. Including News. R ADIO 3 ra. UU5 Stereo Release ol music by Haydn. Holst 1 Si. Rmufty- Korsafcov. Glinka, Prokofiev. Devilish Gossip, interview with John Cbeever. RADIO 4 m. Saturday with Fritz Spiegl. OX5 Enquire Within. HUM News. As Radio 2 London Broadcasting m and After Six. Interviews in Hindustani. CATV J4. Tcf 4B5 62Z5. CC OI-B35 Credit cords. Tue 7. G uardian. Matinee Wed. Owens Dct. W Thur,. Evenings 0. SEE IT. JO The Sleeping Beauty. ES Arnuhi str. Monday la Thurvdar 3. Friday and Saturday a: T34 t. B36 BO om Srdesnc"" j bv Mart. SIS a S. Red, price prevs. Ooens Nor. Eves 8. Saturdays 5. Sab- 3. IO Nov. Also S at N ov. S Wtcl. TS and F, I Evenings 8. Win e Lie. Mon 7. Car tarv Restaurant 7 2d fc! C redit card h jok. Martin Chris: Muladroo I have ; seen The Cuara an -aar. Tnv cord g30 0 B I uclorr New Yorh. OpeiB 7 Nov. Aatbonr Gua. Osavlc's Lear " Financial Times. CC J7 In addition, either one of two Music scholarships of the same value may be awarded annually to girls of any age. Miss V. All levrh. Leclere - Villefranche-uir-Mer - Tel: Part Ldnr. London W1 on Tuesday. To re. By Order cf the Board P F. Roe Secretary 27 October Notes Only members holding fully paid Ordinary shares, or their duly appointed rcDrcsentatim. A member so entitled may appoint a nrovr. EcaR sea -5 ffy. Other Euro- foreigner. On a good day in buyers are telling our nego- eussion recently about by how rate controversy. John's Wood. X may own a thriving The attraction still conunues waiting to buy. X may own a thriving The attraction still conanues waiting to buy. British Ley- because of other factors. The houses and flats to get the fteel slower rate of growth. Ready St John's Wood Hampstead and of selling blight. So in land and the coal miners strike, "invaders" were treated of the city and decide on the to move into properties are the surrounds mean nothin'- to prices leaped upwards surpass- the pound staggers, inflation is exactly as that. London was a best place to buy. Your local of a three day week looms. John's Wood or conductors excepted. His business is failing; the buyer changed all that. If Mr. Y Stores became multi-lingual, influenced the market. NWS 4 Beds. NW3 5 Wellington Ct. Stephens Cl. James 5q. Mawes have received Instructions to sell what must be one or the most distinctive properties In St. Mawes in south-west Cornwall. Known as Trewithit, it enjoys a superb situation with views across the Fal Estuary - to Pendennis Head. It has a ducted oil-fired central heating system. Toler- unsaleable. The explanation flowering carnations for ex- oeoo That was the situation, plants. A beV y of buyers chasing of virus infections. Inemi noiiori hv. It infects a great actual losses caused by vtruj it. It varieties as well as seeking? They systemic insecticides In fact, care to experiment carbendawm: And, of course, battle cry of the front line Great faith was placed on the one corollary of this was that vendors was "find me a rich meristem method of prnpaga- any treatment that merely Arab". This was an anomalv tion 3 fe w cells excised suppressed the symptoms with- in itself as the majority of over- from ll,e fast-growing tips of out eliminating the virus was seas buyers probabiy came sh? The old story of. Peterhead 8 miles Aberdeen 28 miles. Oil Central Heating. Planning permission applied for hotel and extension. G0 per acre In all about 5SS. Let on single Agricultural Tenancy dated February 1. On Wednesday, 22nd November, , at p. Subject m Reterwo. Liverpool 2. A M Cl Magnificent villa situated in its own beautiful seven acre grounds, superb views to Nice, Cannes and the Mediterranean. The house which will accommodate up to 20 people in great comfort, has 10 bedrooms. Two additional cottages in the grounds. The property is for sale with all its quality furnishing at a substantial price. For further details please apply: Thu is the ideal location for chose seeking die best of both worldi. Diane Steward Tel: Excellent swimming— warmest salt wacer. Formerly supported three farms. Chartered Land Agena. Lemon Villas. Truro Tel: South Coast and St. Viewi to the sea oeer otatefuf wooded parkland of S4 acres. Suitable far prime occupation, institutional use or conversion into fiats. Histone I4ch Century buildina at present subl-ng for conversion. Far required Tr crivaie l rr. The newly built: It has 2 conference rooms and a grill restaurant The hotel is centrally situated, but in a secluded spot The hotel is for sale and a quick settlement is wanted, Bergen has rich traditions in tourism and business travel. Would interested buyers please. Tgtotlan, IrtvesUnem areas. HIKpo Home. Honmd Lana. These are ideal for sending to rela- tions and friends at home and overseas, as well as for your own discerning enjoy- ment DEPT. Strum pihaw, Norwich Tel: Telex-- Hampers. Colour brochure on request public notices. Edlnbuntti EBiraR. They make marvellous presents.. Since I last wore about them they have added: I'm convinced, is an art and some penple arc much better at It than others. The old cliche about it being the thought and not the cost that really matters is. Even quite ordinary items like stationery, key-rings, cuff-links, can be transformed into something special if enough imagination and care has gone into choosing them. The one thing they all require is some advance planning. You really must order now if you want to he sure of them being ready for Christmas. You can send a photograph or the message to Sylvia's and they will be dealt with by mail of, alternatively they can be done while you wait. Some people ask for logos, letterheads, others like loving messages. They could be a good addition to a Christmas stocking. Cyril Came and Son, Wentworth Avenue, London N3 do several of the usual personalised items track-suits, towels etc but have recently introduced a nightdress rase which looks quite pretty. In red. Orders take about three weeks. Stephanie Roberts dues very beautiful batik w'ork on silk and can produce scarves that are very distinguished and very individual. She can make scarves of any and every colour except black and you can order them with a name in one corner or with the name used as the motif going right round the whole scarf. There are several sizes. The silk is very fine, the batik work exquisite and you can virtually ask for your own coiourways or design. The pies roust be large— 13 lb, b or 30 Jb. Orders will take about 10 days. Box 19, Swindon. If yon know a golf fanatic Kaleidoscope can also provide a pair of hallmarked sterling silver ball-markers engraved with up to four initials apiece. They are supplied fn a little leather carrying case. Portraits by Care! She loves working in quilted and padded satin which she often prints with her own rather special flowery designs. She has now devised a series of special white polyester satin hot waler-hottle covers and these can be ordered with any special Dame or theme in green, yellow, fuchsia, purple or blue. Special orders can be made to Fitzroy Frag the name of Rose Elliott's company. Box , 4 Reckitt Road, London W4. When ordering you should include your phone number as Rose Elliott may like to consult you about colours or 'other details. She will also send a list of different types of script, flowers or whatever else you would like included in the design. Orders should take up to three weeks. The bottle You must specify whether it is to be 11 ins. There is a choice of four different sorts of canvas 12 holes to the inch is the most popular. The Needle- woman Shop of Regent Street can give advice about choosing. It looks to me quite difficult to do in that although the full-colour photograph 'Is printed on to the canvas there are no absolute directions over which colours to put where and bringing human features to life is not easy. Needlecraft, 60, Holmes dale Road. Teddington, Middlesex. Delivery is about four weeks. Make sure that the print you send is clear; jf necessary cut out irrelevant details in the background. The designs are all, naturally enough, on racing themes, and I suppose on the assumption that racing circles are well-heeled, the prices are not low. V V ViT. MOST of us tend to think that commissioning portraits or sculptures is the province of the very rich or of grand com- panies which want to honour their distinguished presidents. Not many people realise that it is easier, less daunting and Jess expensive than they might imagine to have carried out either a portrait or a sculpture of either themselves or some- body they are fond of. The most reasonable method that I know of unless you have access to an Impecunious and talented future Augustus John is through two organisations that specialise in sifting both artists and potential clients, thus eliminating all the embar- rassment of being face to face with an individual. The National Portraiture Association. Surrey, is a registered charity which uses its funds to support scholarships and it has thus persuaded about 50 distin- guished artists to contribute their services, at reduced fees, in order to benefit the charity. In the past he has designed gravestones, com- memorative plaques, alphabets, exhibition pieces, glass bowls and medals. The fees charged have varied very little since I last wrote about the association nearly four years ago and the method for initiating a commission is much the same. Anybody inter- ested in having a portrait done should write to the association,, at the address given above, enclosing a 9p stamp, and they will then receive a brochure listing all the fees and the different mediums available chalk, pastels, oils and so on. From the illustrations enclosed in the brochure the potential client chooses the kind of style that most suits his taste and from there he can proceed with a commission. They include some very illustrious names like Michael Noakes almost every member of the Royal Family seems to have sat for him. The only artist of whom X have personal experience is Frances Baruch who has just completed a head of my daughter photographed above. She works from home at 16 Clifton Hill, London. NWS, and she works very quickly — she likes between four and six sittings, arranged very close together. She has most recently sculpted one of Sir Georg Solti's children and many other eminent people besides. ALMOST all good-class stationery shops and department stores have an excellent selection of writing-paper with initials incorporated somewhere into the design. Harrods, too, have a good stationery department and this pack of 15 monogrammed note cards, each In cream and navy border with gold letter, is accompanied by cream envelopes lined with navy bine. They will also send by post for 55p extra. The Yeoman gate illustrated is one of our range of craftsman made timber gates, constructed to give prolonged service. Other attractive designs are also available for the garden or farm. Sond 7p far a brochure or vtait m u Blddenden. Height Avt, table in antique shades ot green, red tan or dark raw lor order lorm. Mainland appro,. They have both been Deraarc ation lines and union requests and disc shows with Mr. U tries to leave som p d ne Peter Witt. Everyone tends to do nausic-on-ta: It has. Studio Piano-sirurummg musicians who prT , duC4fd by Mr. Three Force John's have been associated for anthems and the Funeral Sc a few musical seasons now, gen- traces all dating from the co orally mixing ancient and mod- poser's early twenties or befor - ern with fine artistry but, one were preceded by music from t gathers, not too good a response previous generation with whi at the box office. Their new he would have been famil. George Jeffries' v: Osnabrfick, where with each other. Why not. Havms spent Much of the time the station is H US,? In this case. In Nottingham they are engaged on various multi-racial projects. In Derby they have ventured abroad to broadcast programmes from their twin town in Germany. Davis, Joyce Blair and Leonie Cosman. What Derby last Friday when I was the BBC alms to offer is the piere rated more than a few choice between listening to one inches in the national Press but of five services, four of them they were all of major lraport- Network Radios 1 to 41 and one ance to this community: Billy full-blown musical. Anthony directed by Kenneth Chub, at: Quayle, a tough old Lear, should dishonesty in human relat: Ushers Carlin Music who are It will have an all-American cast not be missed. Reviewed Wed- ships. Reviewed Friday. A group of is already arranged. Jesse and m the Rat! S usual here. Thursday, the Cot? Lunchthne hour Daunt. Could that be a about South African politics, set Outside central London, ths a headc air about the studios was a good morning for the Solution to Problem No. E ment as the sline and pebbles mine when a big national storv K-B5: K- about how their shows are musical's cause. Witt is other. The best one I ever made safest recommendation since the latest antics of The Petr. Battles have been fou"ht here breaks io the area. He aware that many British Jews, was as an agent Would you Sleuth. Hypnotic play bv ton: T u ae wnn! Not from Matt; 1 1 though there are many vana- refugee from Nazi Germany alter a long fight and the com- it might have been. When Jarvis Mr. Steve Kulukundist. Witt gave him ail j ded. Jason Ro bards. Lauren Mr. Win prefers to have pro- the appropriate assurances and, elude that the primary aim will sections. For Bacall and Eli Wallach. Football Focus Boxing 1. Motor Sport World Gymnastics Champion- ships t Wales — 8. Scotland — 1. Northern Ireland: Ulster v Connacht. BBC 2 j3. Elite Syncopations; Four Schumann Pieces. Tweedle- dum and Tweedledee: L55 Mind Your L-anguajca. US mm At be End of the Day. SJ0 The Blnmc Woman. US Doctor On the Go. IM0 Saturdar Cinema: OO am Doctor: ID JO Tlswas. UJ0 The Bionic Woman. U Streets of San Francisco. U 30 Logan's Run. Gale Storm. Walter Brennan and Vincent Price. I1J0 Sesame Street. S0 L'niamed World. L55 Mind Your Language. Including News. R ADIO 3 ra. UU5 Stereo Release ol music by Haydn. Holst 1 Si. Rmufty- Korsafcov. Glinka, Prokofiev. Devilish Gossip, interview with John Cbeever. RADIO 4 m. Saturday with Fritz Spiegl. OX5 Enquire Within. HUM News. As Radio 2 London Broadcasting m and After Six. Interviews in Hindustani. CATV J4. Tcf 4B5 62Z5. CC OI-B35 Credit cords. Tue 7. G uardian. Matinee Wed. Owens Dct. W Thur,. Evenings 0. SEE IT. JO The Sleeping Beauty. ES Arnuhi str. Monday la Thurvdar 3. Friday and Saturday a: T34 t. B36 BO om Srdesnc"" j bv Mart. SIS a S. Red, price prevs. J Strength Cond Res 23 5: S1-S59, Perceived yet often misunderstood demands of a sport, overt benefits of anabolic drugs, and the inability to be offered any effective alternatives has fueled anabolic drug abuse despite any consequences. Motivational interactions with many situational demands including the desire for improved body image, sport performance, physical function, and body size influence and fuel such negative decisions. Positive countermeasures to deter the abuse of anabolic drugs are complex and yet unclear. Furthermore, anabolic drugs work and the optimized training and nutritional programs needed to cut into the magnitude of improvement mediated by drug abuse require more work, dedication, and preparation on the part of both athletes and coaches alike. Few shortcuts are available to the athlete who desires to train naturally. Historically, the NSCA has placed an emphasis on education to help athletes, coaches, and strength and conditioning professionals become more knowledgeable, highly skilled, and technically trained in their approach to exercise program design and implementation. Optimizing nutritional strategies are a vital interface to help cope with exercise and sport demands. In addition, research-based supplements will also have to be acknowledged as a strategic set of tools e. Resistance exercise is the most effective anabolic form of exercise, and over the past 20 years, the research base for resistance exercise has just started to develop to a significant volume of work to help in the decision-making process in program design. The interface with nutritional strategies has been less. Growth kinetics of four human breast carcinomas grown in nude mice. The three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations. In the present study one estrogen and progesterone receptor-negative T60 and three receptor-positive Br, MCF-7, T61 human breast cancer xenografts The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis performed on fine-needle aspirations. The results showed that the tumors had growth kinetics comparable to other human tumor types On the growth rate of gallstones in the human gallbladder. The growth rate of a single symmetrically oval shaped gallbladder stone weighing The length of the stone was measured by ultrasonography and the growth rate was found to be linear with time, with a value of 0. The morphology and metallic ion chemical composition of the large stone and of a randomly selected small stone weighing about 1. It was found that the large stone contained besides calcium also lead, whereas the small stone contained mainly calcium. It is possible that the lead causes a difference in mechanism between the growth of a single large and growth of multiple small gallstones. Full Text Available In the process of developing economy in a whole and continuously, the macro economy stability of acountry is an essential prerequisite for producing a quality economic growth. For achieving the qualityeconomic growth , there should be a continuous capital human investment and the use of continuousscience and technology IPTEK. The process of developing economy will be able to transform thesociety condition from vicious circle to virtuous circle condition if the growth of economy is qualified.. Quality of growth ; human capital, technology and virtuous circle. Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor. To determine if fibroblasts could be a source of fibroblast growth factor FGF in tissue, cells were initiated in culture from newborn human foreskin. Fibroblast cell lysates promoted radiolabeled thymidine uptake by cultured quiescent fibroblasts. Seventy-nine percent of the growth -promoting activity of lysates was recovered from heparin-Sepharose. The heparin-binding growth factor reacted on immunoblots with antiserum to human placenta-derived basic FGF and competed with iodinated basic FGF for binding to antiserum to bFGF synthetic peptide. To confirm that fibroblasts were the source of the growth factor, cell lysates were prepared from cells incubated with radiolabeled methionine. Heparin affinity purified material was immunoprecipitated with basic FGF antiserum and electrophoresed. Radiolabeled material was detected on gel autoradiographs in the same molecular weight region as authentic iodinated basic FGF. The findings are consistant with the notion that cultured fibroblasts express basic FGF. As these cells also respond to the mitogen, it is possible that the regulation of their growth is under autocrine control. Fibroblasts may be an important source of the growth factor in tissue. Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Human embryonic stem cells hESCs are thought to be a promising cell source for cell transplantation therapy. For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin rhLM isoforms on the undifferentiated growth of hESCs. The hESCs proliferated on these three rhLMs for several passages while preserving their pluripotency. We analyzed the expression and function of p8 in pancreatic cancer-derived cells. Methods Expression of p8 was silenced in the human pancreatic cancer cell lines Panc-1 and BxPc-3 by infection with a retrovirus expressing p8 RNA in the antisense orientation. Cell growth was measured in control and p8-silenced cells. Influence on p8 expression of the induction of intracellular pathways promoting cellular growth or growth arrest was monitored. Results p8-silenced cells grew more rapidly than control cells transfected with the empty retrovirus. Conclusions p8 inhibits the growth of human pancreatic cancer cells. These results suggest that p8 belongs to a pathway regulating the growth of pancreatic cancer cells. A comparison of fatigue crack growth in human enamel and hydroxyapatite. Cracks and craze lines are often observed in the enamel of human teeth, but they rarely cause tooth fracture. The present study evaluates fatigue crack growth in human enamel, and compares that to the fatigue response of sintered hydroxyapatite HAp with similar crystallinity, chemistry and density. The specimens were subjected to mode I cyclic loads and the steady state crack growth responses were modeled using the Paris Law. In regions of decussation, the microstructure promoted microcracking, crack bridging, crack deflection and crack bifurcation. Working in concert, these mechanisms increased the crack growth resistance and resulted in a sensitivity to crack growth m similar to bone and lower than that of human dentin. These mechanisms of toughening were not observed in the crack growth response of the sintered HAp. While enamel is the most highly mineralized tissue of the human body, the microstructural arrangement of the prisms promotes exceptional resistance to crack growth. The Case of Macedonia. Full Text Available The main objective of the paper is to explore the assumption if the lack of skilled and well-educated workforces human capital holds a potential of a binding constraint to economic growth of the Macedonian economy. The empirical techniques used in this paper are: The estimated results indicate an important contribution of human capital to economic growth its relative contribution in terms of growth rate composition is approximately 22 percent. The macro and micro assessment of the rate of return on investment in human capital shows that the rate of return to higher education is significantly superior to corresponding returns to secondary education. Finally, the international benchmark analysis helps in comparative human capital impact analysis educational structure of labor force in the wider region. From the birth of the human capital theory, economists were interested to find evidences showing the impact of the human capital on the economic output, discussing and debating more or less the effect of economic growth on the accumulation of human capital in the economy and the association between education and health. The paper aims to test several econometric models to explain the relationship between human capital and economic output. Using World Bank data, 17 countries with the fastest e Insulin infusion reduces hepatocyte growth factor in lean humans. Plasma Hepatocyte Growth Factor HGF is significantly elevated in obesity and may contribute to vascular disease, metabolic syndrome or cancer in obese individuals. The current studies were done to determine if hyperinsulinemia increases plasma HGF. Twenty-two parti Influence of topical human epidermal growth factor on postkeratoplasty re-epithelialisation. Dellaert; T. Casey; S. Wiffen; J. Gordon Jocelynne ; P. Geerards Annette ; W. Rijneveld Wilhelmina ; L. Remeijer Lies ; W. Beekhuis Houdijn ; P. Mulder Paul. To test the efficacy and safety of recombinant human epidermal growth factor hEGF on corneal re-epithelialisation following penetrating keratoplasty. A prospective, randomised, placebo controlled study was carried out in which patients were. Human milk oligosaccharides inhibit growth of group B Streptococcus. Streptococcus agalactiae group B Streptococcus, GBS is a leading cause of invasive bacterial infections in newborns, typically acquired vertically during childbirth secondary to maternal vaginal colonization. Human milk oligosaccharides HMOs have important nutritional and biological activities. Human Capital and Economic Growth: The study examines the role of human capital in the economic growth of Pakistan by using primary, secondary and higher education enrolments as proxies for human capital in three different specifications. The idea behind these models is to find out the most relevant level of education in terms of its contribution in economic growth. The order of integration of the variables is checked through Augmented Dickey Fuller and Phillips Perron test. In order to find out the evidences of the long run r Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure? Growth hormone treatment has gained attention over the past decade as a treatment for heart failure. Human growth hormone HGH must be administered by injections usually daily , so there is considerable advantage to stimulation of endogenous secretion by amino acid-based nutritional. Inhibition of uropathogenic biofilm growth on silicone rubber in human urine by lactobacilli - a teleologic approach. The ability of three Lactobacillus strains to inhibit the adhesion and growth of naturally occurring uropathogens on silicone rubber was investigated in human urine. The importance of biosurfactant production by Lactobacillus in discouraging uropathogen growth was determined in relation to the. Monitoring human growth and development: Villar, Jose; Papageorghiou, Aris T. Alison; Gravett, Michael G. A comprehensive set of fully integrated anthropometric measures is needed to evaluate human growth from conception to infancy so that consistent judgments can be made about the appropriateness of fetal and infant growth. At present, there are 2 barriers to this strategy. First, descriptive reference. An Interactive Effect. Full Text Available Various studies have focused on the relationship between human capital and economic growth all over the world. However, there is still a missing gap on the joint influence of human capital investment components on economic growth particularly in Nigeria. This study therefore examines the interactive effects of the relationship between human capital investment components and economic growth in Nigeria for the period of — The study employed secondary annual data on education expenditure, health expenditure, real gross domestic product and gross capital formation obtained from the Central Bank Statistical bulletin, The results of the study showed that there was positive and significant relationship between the interactive effects of human capital components and growth in Nigeria. Human epidermal growth factor: Epidermal growth factor EGF , a 53 amino acid polypeptide, was first isolated by Cohen. EGF's growth -promoting activity is not limited to epidermal cells, but is expressed on a wide variety of tissues derived from a number of different species. Using these assays, the molecular size of hEGF in human body fluids and tissues was evaluated, and partial characterization of a high molecular weight form of hEGF isolated from human urine was carried out. The concentrations of immunoreactive hEGF were also determined in human tissues and plasma after extraction either with cationic exchange chromatography or with immunoaffinity chromatography. Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature. We studied nine children who had received cranial irradiation for various malignancies and subsequently experienced decreased growth velocity. Their response to standard growth hormone stimulation and release tests were compared with that in seven children with classic GH deficiency and in 24 short normal control subjects. Only two of nine patients had a normal response to insulin hypoglycemia, with no significant differences in the mean maximal response of the radiation and the GH-deficient groups. Pulsatile secretion was not significantly different in the radiation and GH-deficient groups, but was different in the radiation and normal groups. All subjects in the GH-deficient and radiation groups were given human growth hormone for 1 year. Growth velocity increased in all, with no significant difference in the response of the two groups when comparing the z scores for growth velocity of each subject's bone age. We recommend a 6-month trial of hGH in children who have had cranial radiation and are in prolonged remission with a decreased growth velocity, as there is no completely reliable combination of GH stimulation or release tests to determine their response. Stimulation of class II molecules by monoclonal antibodies mAbs or bacterial superantigens induces protein tyrosine phosphorylation through activation of protein tyrosine kinases in T cells, and class II signals There was no correlation between T cell responsiveness to class II and the cytokine production profile of the T cell in question. Here, we studied further the role of class II molecules in the regulation of T cell growth. Human disturbance influences reproductive success and growth rate in California sea lions Zalophus californianus. Full Text Available The environment is currently undergoing changes at both global e. Many of these changes, such as human disturbance, have an anthropogenic origin and therefore may be mitigated by management action. To do so requires an understanding of the impact of human activities and changing environmental conditions on population dynamics. We investigated the influence of human activity on important life history parameters reproductive rate, and body condition, and growth rate of neonate pups for California sea lions Zalophus californianus in the Gulf of California, Mexico. Increased human presence was associated with lower reproductive rates, which translated into reduced long-term population growth rates and suggested that human activities are a disturbance that could lead to population declines. We also observed higher body growth rates in pups with increased exposure to humans. Increased growth rates in pups may reflect a density dependent response to declining reproductive rates e. Our results highlight the potentially complex changes in life history parameters that may result from human disturbance, and their implication for population dynamics. We recommend careful monitoring of human activities in the Gulf of California and emphasize the importance of management strategies that explicitly consider the potential impact of human activities such as ecotourism on vertebrate populations. HSPGs bind to numerous growth factor ligands including fibroblast growth factors FGF , epidermal growth factors EGF , and vascular endothelial growth factors VEGF , and are critically important in the context of cancer cell growth , invasion, and metastasis. We hypothesized that sulfatase activity in the tumor microenvironment would regulate tumor growth in vivo. We established a model of stable expression of sulfatases in the human breast cancer cell line MDA-MB and purified recombinant human Sulfatase 2 rhSulf2 for exogenous administration. In vitro studies were performed to measure effects on breast cancer cell invasion and proliferation, and groups were statistically compared using Student's t-test. The effects of hSulf2 on tumor progression were tested using in vivo xenografts with two methods. Secondly, wild type MDA-MB xenografts were treated by short-term intratumoral injection with rhSulf2 or vehicle during tumor growth. Ultrasound analysis was also used to complement caliper measurement to monitor tumor growth. In vivo studies were statistically analyzed using Student's t test. In vitro, stable expression of hSulf2 or administration of rhSulf2 in breast cancer cells decreased cell proliferation and invasion, corresponding to an inhibition of ERK activation. Stable expression of the sulfatases in xenografts significantly suppressed tumor growth , with complete regression of tumors expressing both hSulf1 and hSulf2 and significantly smaller tumor volumes in groups expressing hSulf1 or hSulf2 compared to control xenografts. Despite significant suppression of tumor volume, sulfatases did not affect vascular. Too much of a good thing? Economic growth and human rights, to Despite widespread belief in the benefits of economic growth , some scholars emphasize the potentially negative consequences of growth -and especially rapid growth -for social and political outcomes. Using data for countries between and , I analyze the effect of economic growth on fundamental human rights conditions. Dynamic random-effects and two-way fixed-effects estimators, both with and without instrumental variables, yield several conclusions. First, economic growth is causally prior to rights conditions. Second, economic growth has a modest positive effect on human rights, albeit with diminishing returns at high growth rates. Third, low-income countries account for much of this relationship: Growth has little effect among middle-income countries, while for high-income countries the relationship is positive but not robust. I bring these findings to bear on long-standing debates between proponents and critics of modernization theory. Cell-autonomous intracellular androgen receptor signaling drives the growth of human prostate cancer initiating cells. The lethality of prostate cancer is due to the continuous growth of cancer initiating cells CICs which are often stimulated by androgen receptor AR signaling. However, the underlying molecular mechanism s for such AR-mediated growth stimulation are not fully understood. We utilized clinical samples, animal models and a series of AR-positive human prostate cancer cell lines to evaluate AR-mediated growth stimulation of prostate CICs. This lack of a requirement for AR expression in tumor stromal cells is also documented by the fact that human AR-positive prostate cancer cells grow equally well when xenografted in wild-type versus AR-null nude mice. AR-dependent growth stimulation was documented to involve secretion, extracellular binding, and signaling by autocrine growth factors. Orthotopic xenograft animal studies documented that the cellautonomous autocrine growth factors which stimulate prostate CIC growth are not the andromedins secreted by normal prostate stromal cells. The identification of such AR-dependent intracellular pathways offers new leads for the development of effective therapies for prostate cancer. In this paper we use high quality data from two developing countries, Ethiopia and Peru, to estimate the production functions of human capital from age 1 to age We characterize the nature of persistence and dynamic complementarities between two components of human capital: We also explore the implications of different functional form assumptions for the production functions. We find that more able and higher income parents invest more, particularly at younger ages when investments have the greatest impacts. These differences in investments by parental income lead to large gaps in inequality by age 8 that persist through age Role of Insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries. Polycystic ovary syndrome PCOS , the commonest cause of anovulatory infertility, is characterized by disordered follicle development including increased activation and accelerated growth of preantral follicles. Data from experimental animals and preliminary results from studies of human ovarian tissue suggest that IGFs affect preantral follicle development. Our objectives were to investigate the expression of the type-1 IGF receptor IGFR-1 in the human ovary and to determine whether IGFs are involved in stimulating the transition of follicles from primordial to primary stage in normal and polycystic ovaries. We used archived ovarian tissue for protein expression studies and small cortical biopsies for follicle isolation and for tissue culture. This was a laboratory-based study, using clinical tissue samples. A total of 54 women, 33 with normal ovaries and 21 with polycystic ovaries, were classified by reference to menstrual cycle history and ultrasonography. We evaluated expression of IGFR-1 mRNA in isolated preantral follicles and of IGFR-1 protein in archived ovarian tissue samples from normal and polycystic ovaries and effects of exogenous IGF-1 on preantral follicle development and survival in cultured fragments of normal and polycystic ovaries. IGF-1 stimulated initiation of follicle growth in normal tissue but had little effect on preantral follicle growth in polycystic ovaries in which, characteristically, there was a higher proportion of follicles that had entered the growing phase even before culture. IGFs are plausible candidates in regulation of initiation of human follicle growth , and accelerated preantral follicle growth in PCOS may be due to increased activity of endogenous IGFs. Soffers, Jelly H. Eleonore; Lamers, Wouter H. The topography of. Hemispheric Specialization and the Growth of Human Understanding. Connectionistic notions of hemispheric specialization and use are incompatible with the network organization of the human brain. Mouse hybridomas secreting antibodies to human insulin-like growth factor I IGF I were produced by fusion of spleen cells of hyperimmunised mice with FO mouse-myeloma cells. Eight clones producing antibodies against human IGF I have been isolated, two of which have been characterised. One was used in a radioimmunoassay, the other for immunopurification of IGF. Fracture processes and mechanisms of crack growth resistance in human enamel. But contributions from the microstructure to the fracture toughness and the mechanisms of crack growth resistance have not been explored in detail. In this investigation the apparent fracture toughness of human enamel and the mechanisms of crack growth resistance were evaluated using the indentation fracture approach and an incremental crack growth technique. Indentation cracks were introduced on polished surfaces of enamel at selected distances from the occlusal surface. In addition, an incremental crack growth approach using compact tension specimens was used to quantify the crack growth resistance as a Junction of distance from the occlusal surface. There were significant differences in the apparent toughness estimated using the two approaches, which was attributed to the active crack length and corresponding scale of the toughening mechanisms. Urinary transforming growth factors in neoplasia: Purified human epidermal growth factor hEGF from urine promotes anchorage-independent cell growth in soft agar medium. This growth is enhanced by transforming growth factor-beta TGF-beta , and is specifically inhibited by hEGF antiserum. Transforming growth factors of the alpha type TGF-alpha , potentially present in normal human urine or urine from tumor-bearing patients, also promote anchorage-independent cell growth and compete with EGF for membrane receptor binding. Therefore, a technique for separation of TGF-alpha and related peptides from urinary EGF based on biochemical characteristics would be useful. Fcks sex. Electric three wheel bikes for adults. The good qualities support the Fisting. Mommy turkey. Tori wilson big tits. Chat cyber free sex sex. Depilando o penis. Teen girls flashing in public. Horses mating videos only. Took a real prostitute Russian porn. Porn throat Blowjob for free. Selfshot tongue. Bisexual male stripper. Sinister minister costume. Miyabi clitoris. Shaved pussy asian close up. Black women wi. Raped drunken girls. Free porn fucked quietly speshul mom. Porn hd the nuns in latex. Stories of a demon, a member of the anus. Secs erotika com. British Granny porn. Husband cum eating. 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The serum concentrations of insulin-like growth factor-I in the recombinant No significant changes were seen in the area under the curve for biochemical liver function tests. We conclude that administration of recombinant human growth hormone induces This research postulates that prostate cancer cells commandeer this normal epithelial-mesenchymal signaling pathway to recruit stromal cells to support abnormal tumor growth and tests the hypothesis Potency testing of mesenchymal stromal cell growth expanded in human platelet lysate from different human tissues.

Mesenchymal stromal cells MSCs have been largely investigated, in the past decade, as potential therapeutic strategies for various acute and chronic pathological conditions. MSCs isolated from different sources, such as bone marrow BMumbilical cord tissue UCT and adipose tissue AT Rin aoki porn etotic clips, share many biological features, although they may show some differences on cumulative yield, proliferative ability and differentiation potential.

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MSCs morphology, phenotype, differentiation potential, and immunomodulatory properties were also investigated to evaluate their biological characteristics. The use of standardized PL-based culture conditions resulted in a very low variability of MSC growth. The adoption of standardized culture conditions may help Rin aoki porn etotic clips and clinicians to reveal particular characteristics and inter-individual variability of MSCs sourced from click at this page tissues.

These data will be beneficial to set the standards for tissue collection and MSCs clinical-scale expansion both for cell banking.

Full Text Available It is obvious that human capital is critical for economic growth. The paper aims to investigate the relationships between human capital and economic growth in the romanian economy by analyzing the correlations between statistical variables measuring human capital and economic growth.

Sex vientiane Watch Video Jpegs Cumshots. Black-Right-Pointing-Pointer Demonstrate Triparanol can block proliferation in multiple cancer cells. Black-Right-Pointing-Pointer Demonstrated Triparanol can impede tumor growth in vivo in mouse xenograft model. Despite the improved contemporary multidisciplinary regimens treating cancer, majority of cancer patients still suffer from adverse effects and relapse, therefore posing a significant challenge to uncover more efficacious molecular therapeutics targeting signaling pathways central to tumorigenesis. Here, our study have demonstrated that Triparanol, a cholesterol synthesis inhibitor, can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol. Remarkably, we have proved Triparanol can significantly repress Hedgehog pathway signaling in these human cancer cells. Furthermore, study in a mouse xenograft model of human lung cancer has validated that Triparanol can impede tumor growth in vivo. We have therefore uncovered Triparanol as potential new cancer therapeutic in treating multiple types of human cancers with deregulated Hedgehog signaling. Numerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known. To identify genes controlling glioma invasion, we used genome-wide mRNA expression profiles of primary human glioblastomas to develop an expression-based rank ordering of 30 transcription factors that have previously been implicated in the regulation of invasion and metastasis in cancer. SNAI2 mRNA expression correlated with histologic grade and invasive phenotype in primary human glioma specimens, and was induced by EGF receptor activation in human glioblastoma cells. Surface-bounded growth modeling applied to human mandibles. This thesis presents mathematical and computational techniques for three dimensional growth modeling applied to human mandibles. The longitudinal shape changes make the mandible a complex bone. The teeth erupt and the condylar processes change direction, from pointing predominantly backward A local shape feature called crest line has shown itself to be structurally stable on mandibles. Registration of crest lines from different mandibles results in a sparse deformation field, which must be interpolated When using successively more recent scans as basis for the model the error drops to 2. Thus, it seems reasonable to assume that the mandibular growth is linear Human pituitary and placental hormones control human insulin-like growth factor II secretion in human granulosa cells. Human granulosa cells cultured with calf serum actively proliferated for generations and secreted progesterone into the medium; progesterone levels appeared to decline with increase in generation number. The progesterone secretion was enhanced by the addition of human follitropin, lutropin, and chorionic gonadotropin but not by growth hormone. These cells, when challenged to varying concentrations of human growth hormone, human chorionic somatomammotropin, human prolactin, chorionic gonadotropin, follitropin, and lutropin, secreted IGF-II into the medium as measured by specific IGF-II RIA. Among these human hormones, chorionic gonadotropin, follitropin, and lutropin were most effective in inducing IGF-II secretion from these cells. The results described suggest that cultured human granulosa cells can proliferate and actively secrete progesterone and IGF-II into the medium. IGF-II production in human granulosa cells was influenced by a multi-hormonal complex including human growth hormone, human chorionic somatomammotropin, and prolactin. Purification of human platelet-derived growth factor. The paper describes a method for purification of human platelet-derived growth factor PDGF from outdated platelet-rich plasma PRP using commonly available laboratory reagents and yielding a mitogen purified ,fold over the starting material. Other assays to quantitate PDGF include radioreceptor assay and radioimmunoassay. Gold thread implantation promotes hair growth in human and mice. Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When embedded into the depilated Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Objective Dysregulation of WNT signaling plays a central role in tumor cell growth and progression. Design Prospective study of human leiomyoma cells obtained from myomectomy or hysterectomy. Setting University research laboratory. Our findings provide rationale for further preclinical and clinical evaluation of ICAT, niclosamide, and XAV as candidate anti-tumor agents for uterine leiomyoma. AMPK regulation of the growth of cultured human keratinocytes. Saha, Asish K. In the present study, we examined the relationship between AMPK activation and the growth proliferation of cultured human keratinocytes and assessed whether the inhibition of keratinocyte growth by vitamin D involves AMPK activation. In addition, we explored whether the inhibition of keratinocyte proliferation as they approach confluence could be AMPK-related. Like most cells, the growth of keratinocytes diminished as they approached confluence. Both showed nitrogen retention on balance studies, the older second patient to a marked degree. In the younger patient, height increased from The rate of growth approximately doubled during the first two treatment periods as compared with the pre-treatment rate. In the second older patient hgh was administered 5 mg daily intramuscularly for 21 out of 33 months. Growth from This increased growth rate occurred during the post-puberty deceleration phase. Transient adolescent gynecomastia appeared in Case 2. No local or general toxic effects were noted. These results are suggestive, but whether or not the eventual height of an achondroplastic dwarf can be significantly altered must await further studies. ImagesFigure 1. Figure 2. Selection and characterization of a human neutralizing antibody to human fibroblast growth factor Compelling evidences suggest that fibroblast growth factor-2 FGF-2 plays important roles in tumor growth , angiogenesis and metastasis. Molecules blocking the FGF-2 signaling have been proposed as anticancer agents. Through screening of a human scFv phage display library, we have isolated several human single-chain Fv fragments scFvs that bind to human FGF After expression and purification in bacteria, one scFv, named 1A2, binds to FGF-2 with a high affinity and specificity, and completes with FGF-2 binding to its receptor. In a set of vitro assays, it inhibited various biological activities of FGF-2 such as the proliferation, migration and tube formation of human umbilical vein endothelial cells. More importantly, hIgGA2 antibody also efficiently blocked the growth while inducing apoptosis of glioma cells. For the first time, we generated a human anti-FGF-2 antibody with proven in vitro anti-tumor activity. It may therefore present a new therapeutic candidate for the treatment of cancers that are dependent on FGF-2 signaling for growth and survival. Epidermal growth factor receptor in primary human lung cancer. Cell membranes were prepared from 12 human lung cancers for the study of the expression of epidermal growth factor receptors EGFR. The dissociation constants of the high affinity sites were identical, 1. These results suggest that EGF and its receptor may play a role in the regulatory mechanisms in the control of lung cellular growth and tumor promotion. A Big Bang model of human colorectal tumor growth. What happens in early, still undetectable human malignancies is unknown because direct observations are impractical. Here we present and validate a 'Big Bang' model, whereby tumors grow predominantly as a single expansion producing numerous intermixed subclones that are not subject to stringent selection and where both public clonal and most detectable private subclonal alterations arise early during growth. Genomic profiling of individual glands from 15 colorectal tumors showed an absence of selective sweeps, uniformly high intratumoral heterogeneity ITH and subclone mixing in distant regions, as postulated by our model. We also verified the prediction that most detectable ITH originates from early private alterations and not from later clonal expansions, thus exposing the profile of the primordial tumor. Moreover, some tumors appear 'born to be bad', with subclone mixing indicative of early malignant potential. This new model provides a quantitative framework to interpret tumor growth dynamics and the origins of ITH, with important clinical implications. The liver taxis of receptor mediated lactosaminated human growth hormone. Radiography imaging is used to assess liver taxis mechanism of anti-dwarfism drug lactosaminated human growth hormone L-rhGH. Both L-rhGH and rhGH labelled with I are used to study their biodistribution in animals including rabbits, cocks and rats. The results show that L-rhGH is of specific hepatic targeting property, and the maximum hepatic concentration rate is Its hepatic binding is receptor mediated. Expression of epidermal growth factor receptors in human endometrial carcinoma. Little data exist on the expression of epidermal growth factor receptors EGF-Rs in human endometrial cancer. EGF-R was identified on frozen tissue sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the external domain of the EGF-R. Seventy-one percent of the carcinomas expressed positive EGF-R immunoreactivity. In general, staining was most prominent Radioimmunological activity of 22K variant of human growth hormone. From a preparation of human growth hormone its integral variant hGHK was isolated by isoelectric focusing, having a pI of 5,20 and relative mobility Rm of 0, in the polyacrylamide gel electrophoresis. Several experiments for the characterization of the isolated variant were carried out. The immunological properties was tested by radioimmunoassay RIE , in which the activity of the isolated variant and the activity of the total preparation were compared. The dose response-curves obtained by RIE were found to be considered parallels p [pt. To determine the rate of growth of these colonies, recipes were developed using CL-Quant software which enables users to extract various types of data from video images. To accurately evaluate colony growth , three recipes were created. The first segmented the image into the colony and background, the second enhanced the image to define colonies throughout the video sequence accurately, and the third measured the number of pixels in the colony over time. The three recipes were run in sequence on video data collected in a BioStation CT to analyze the rate of growth of individual hESC colonies over 48 hours. To verify the truthfulness of the CL-Quant recipes, the same data were analyzed manually using Adobe Photoshop software. When the data obtained using the CL-Quant recipes and Photoshop were compared, results were virtually identical, indicating the CL-Quant recipes were truthful. The method described here could be applied to any video data to measure growth rates of hESC or other cells that grow in colonies. Short-term effects of recombinant human growth hormone and feeding on gluconeogenesis in humans. After a short-term fast, lactating women have increased rates of glucose production but not gluconeogenesis GNG despite relative hypoinsulinemia. We explored the effects of non-insulin-dependent increase in glucose utilization and recombinant human growth hormone rhGH on glucose production, glyc Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone. The growth hormone GH -deficient dwarf rat was used to investigate recombinant human rh GH-induced bone formation and to determine whether rhGH facilitates simultaneous increases in bone formation and bone maturation during rapid growth. The GH group received 1. Biochemical, morphological, and X-ray diffraction measurements were performed on the femur middiaphysis. Adaptation to statins restricts human tumour growth in Nude mice. Statins have long been used as anti-hypercholesterolemia drugs, but numerous lines of evidence suggest that they may also bear anti-tumour potential. We have recently demonstrated that it was possible to isolate cancer cells adapted to growth in the continuous presence of lovastatin. These cells grew more slowly than the statin-sensitive cells of origin. In the present study, we compared the ability of both statin-sensitive and statin-resistant cells to give rise to tumours in Nude mice. HGT-1 human gastric cancer cells and L50 statin-resistant derivatives were injected subcutaneously into Nude mice and tumour growth was recorded. At the end of the experiment, tumours were recovered and marker proteins were analyzed by western blotting, RT-PCR and immunohistochemistry. L50 tumours grew more slowly, showed a strong decrease in cyclin B1, over-expressed collagen IV, and had reduced laminin , VEGF and CD34 levels, which, collectively, may have restricted cell division, cell adhesion and neoangiogenesis. Taken together, these results showed that statin-resistant cells developed into smaller tumours than statin-sensitive cells. This may be reflective of the cancer restricting activity of statins in humans , as suggested from several retrospective studies with subjects undergoing statin therapy for several years. Homologous radioimmunoassay for human epidermal growth factor urogastrone. Epidermal growth factor EGF , a polypeptide hormone originally discovered in the mouse submaxillary gland, stimulates growth in a variety of tissues in several species. This hormone has recently been identified in human urine. In general, levels were similar to those recently reported using a heterologous RIA system. Excretion by females taking oral contraceptives was significantly greater Several of those with very low values had histories of alcohol abuse. Excretion by patients with Cushing's syndrome was normal. Patients with psoriasis or recovering from major burns excreted both abnormally high and abnormally low levels of RIA-hEGF, with no obvious correlation to their clinical condition. And, hair re- growth promotion in the gold threadimplanted mice were significantly higher than that in PGA thread group on day 11 after depilation. In particular, the skin tissue of gold thread-implanted mice showed stronger PCNA staining and higher collagen density compared with control mice. Effect of temperature on the radioiodination of human growth hormone. Studies have been undertaken to assess the effect of altering the temperature at which human growth hormone is radioiodinated on the incorporation of I and the immunoreactivity and stability of the labelled hormone. Employing highly purified monomeric hormone it proved possible, by the iodogen procedure, to prepare a labelled product of high specific activity irrespective of temperature. However, in radioiodinations performed at ambient temperature 20 to 25 degrees significant amounts of the labelled hormone were in an aggregated form which was less immunoreactive than the I-labelled monomeric hormone. From a set of 31 three-dimensional CT scans we model the temporal shape and size of the human mandible. Each anatomical structure is represented using semi-landmarks, and mapped into Procrustes tangent space. Exploratory subspace analyses are performed leading to linear models of mandible The traditional variance analysis results in a one-dimensional growth model. However, working in a non-Euclidean metric results in a multimodal model with uncorrelated modes of biological variation. The applied non-Euclidean metric is governed by the correlation The generative models are compared, and evaluated on the basis of a cross validation study. The new non-Euclidean analysis is completely data driven. It not only gives comparable results w. IL-8 had no effect. Epidermal growth factor and its receptors in human pancreatic carcinoma. The role of epidermal growth factor EGF in oncogenesis and progression of malignant tumors is a subject of vast interest. In this study, radioimmunoassay and radioreceptor assay of EGF were established. EGF contents in malignant and benign pancreatic tumors, in normal pancreas tissue, and in culture media of a human pancreatic carcinoma cell line were determined. EGF receptor binding studies were performed. It was shown that EGF contents in pancreatic carcinomas were significantly higher than those in normal pancreas or benign pancreatic tumors. EGF was also detected in the culture medium of a pancreatic carcinoma cell line. The binding of I-EGF to the pancreatic carcinoma cells was time and temperature dependent, reversible, competitive, and specific. Scatchard analysis showed that the dissociation constant of EGF receptor was 2. Human milk fortification strategies for improved in-hospital growth of Human milk is the preferred feed for preterm infants, yet it may need to be fortified for optimal growth and development. Standard fortification of human milk seldom meets the recommended intake of protein, leading to inadequate post-natal growth. This article aims to critically review different human milk fortification Developmental regulation of human truncated nerve growth factor receptor. DiStefano, P. Urine samples were collected from 70 neurologically normal subjects ranging in age from 1 month to 68 years. By using this sensitive two-site radiometric immunosorbent assay, NGF-Rt levels were found to be highest in urine from 1-month old subjects. No evidence for diurnal variation of adult NGF-Rt was apparent. Pregnant women in their third trimester showed significantly elevated urine NGF-Rt values compared with age-matched normals. These data show that NGF-Rt is developmentally regulated in human urine, and are discussed in relation to the development and maturation of the peripheral nervous system. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Human papilloma virus HPV types 16 and 18 are most commonly associated with cervical carcinoma in patients and induce immortalization of human keratinocytes in culture. HPV has not been associated with breast cancer. This report describes the immortalization of normal human mammary epithelial cells 76N by plasmid pHPV18 or pHPV16, each containing the linearized viral genome. Transfectants were grown continuously for more than 60 passages, whereas 76N cells senesce after passages. The transfectants also differ from 76N cells in cloning in a completely defined medium called D2 and growing a minimally supplemented defined medium D3 containing epidermal growth factor. HPV transfectants do not form tumors in a nude mouse assay. It is concluded that products of the HPV genome induce immortalization of human breast epithelial cells and reduce their growth factor requirements. This result raises the possibility that HPV might be involved in breast cancer. Furthermore, other tissue-specific primary epithelial cells that are presently difficult to grown and investigate may also be immortalized by HPV. Expression of the human growth hormone variant gene in cultured fibroblasts and transgenic mice. The nucleotide sequence of the human growth hormone variant gene, one of the five members of the growth hormone gene family, predicts that it encodes a growth hormone-like protein. The growth hormone variant protein expressed in transiently transfected L cells is distinct from growth hormone itself with respect to reactivity with anti- growth hormone monoclonal antibodies, behavior during column chromatography, and isoelectric point. Transgenic mice expressing the growth hormone variant protein are 1. Algorithmic complexity of growth hormone release in humans. Most hormones are secreted in an pulsatile rather than in a constant manner. This temporal pattern of pulsatile hormone release plays an important role in the regulation of cellular function and structure. In healthy humans growth hormone GH secretion is characterized by distinct pulses whereas patients bearing a GH producing tumor accompanied with excessive secretion acromegaly exhibit a highly irregular pattern of GH release. It has been hypothesized that this highly disorderly pattern of GH release in acromegaly arises from random events in the GH-producing tumor under decreased normal control of GH secretion. Using a context-free grammar complexity measure algorithmic complexity in conjunction with random surrogate data sets we demonstrate that the temporal pattern of GH release in acromegaly is not significantly different from a variety of stochastic processes. In contrast, normal subjects clearly exhibit deterministic structure in their temporal patterns of GH secretion. Our results support the hypothesis that GH release in acromegaly is due to random events in the GH-producing tumorous cells which might become independent from hypothalamic regulation. Clinical impact of biotechnology has been constrained by the limitations of traditional hypodermic injection of biopharmaceuticals. Microneedle patches have been proposed as a minimally invasive alternative. In this study, we assess the translation of a dissolving microneedle patch designed for simple, painless self-administration of biopharmacetucials that generates no sharp biohazardous waste. After manual insertion into the skin of hairless rats, hGH pharmacokinetics were similar to conventional subcutaneous injection. After patch removal, the microneedles had almost completely dissolved, leaving behind only blunt stubs. The dissolving microneedle patch was well tolerated, causing only slight, transient erythema. This study suggests that a dissolving microneedle patch can deliver hGH and other biopharmaceuticals in a manner suitable for self-administration without sharp biohazardous waste. Humanized versus murine anti- human epidermal growth factor receptor monoclonal antibodies for immunoscintigraphic studies. Morales, Alejo A. The mAb ior C5 that recognizes an antigen expressed preferentially on the surface of malignant and cytoplasm of normal colorectal cells was used as negative control. Among all organs significant accumulation was found in tumor 6. The immunoreactive fractions were found to be 0. Thus, we expect better results using the humanized mAb h-R3 for diagnostic immunoscintigraphy. The anti- human epidermal growth factor receptor EGF-R humanized antibody h-R3 IgG 1 , which binds to an extracellular domain of EGF-R, was used to evaluate the biodistribution on nude mice xenografted with A epidermoid carcinoma cell line. Immunoreactivity of 99m Tc-labeled mAbs was measured by enzyme linked immunosorbent assay on A cell line and the immunoreactive fractions determined by Lindmo method. Full Text Available In order to address the direction of causality between human capital and productivity growth in Nigeria, the study first investigated the pattern of productivity growth in Nigeria between and Following the endogenous growth model, which argued that technical progress, through an effective labor force, could lead to long-run growth which can be determined from within an economy; but it actually depends on the efficiency with which resources available to such an economy are utilized. This is against the exogenous growth model which emphasized that long-run growth can be attained by some unexplained technological progress, which is exogenous to any economy. Based on this controversy in literature, this study empirically determined the productivity growth in Nigeria, as well as the causal relation between human capital development and productivity growth in Nigeria using the Engle-Granger causality test. The results revealed that productivity growth has been very low and unstable in Nigeria as it oscillated between In addition, the nexus between human capital and productivity growth was examined. Horses mating videos only. Took a real prostitute Russian porn. Porn throat Blowjob for free. Selfshot tongue. Bisexual male stripper. Sinister minister costume. Miyabi clitoris. Shaved pussy asian close up. Black women wi. Raped drunken girls. Free porn fucked quietly speshul mom. Porn hd the nuns in latex. Stories of a demon, a member of the anus. Secs erotika com. British Granny porn. Husband cum eating. Bmpu Negros crowd one skinny little Asian chick watch online. Nude miniskirt teen. Fucks 13 year old porn. Fred flintstone porn videos. Little girls nude sucking a dick. Katy perry naked with cum facial. Porn online Japanese girls best. Fucked between Boobs comic. Russian shakers porn videos. 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Indications for the second and third weeks arc that sales are lower, bill still very strong. The sudden sales surge re- flects the fact that -from October 1. Yet this jump in sales no- where near represents the full potential that could have taken place. There are about lira persons holding these certifi- cates, of whom over lm held the maximum holding before October 1. Looking to the immediate future' and the likely movement in the Retail Price Index, the official forecasts are that the year-on-year increase will re- main around S per cent for the next six months. But unofficial forecasts of r the rise of the RPI in the next 12 months vary from 6 to 12 per cent depending on the view on forthcoming wase settlements. Stockbrokers Phillips anti Drew, for example, is forecasting an They have lo watch patiently as the assistant goes through the palaver of stamping the benefit book, removing a counterfoil and counting our the money. The procedures are more appropriate in the days of the Penny Black than to an institu- tion that is now loading the world in such high-tech oology fields as Viewdata. From the outside, one would have though! And for working mothers in particular — who are more likely than stay-at-home wives to have their own bank accounts — the freedom from The need to traipse regularly to the Post Office would be a major boon. The Department of Social Security secs immense obstacles but it admitted this week that it has at least begun to study seriously the possibility of pay- ing the benefits by credit trans- fer where a mother so desiTes. The officials are also looking at the question of paying the Old Age Pension by credit trans- fer. The proportion of pen- sioners who bave bank accounts is lower than for the active population: No figures are available but the Department seems to fear that the savings to it later on would not com- pensate for the extra expenses early on. Two payment systems would involve a great deal of duplication of effort, the Depart- ment adds. But it is not as if the sums the Department is paying nui are small: The Depart- ment is pressing ahead with cninnilinc a report for ministers. But such a dogmatic view- point seems to assume that husbands and wives are con- stantly bickering over ihe house- keeping money. Any wife who is happy about the way the family's finances are shared out and does not agree that this view is typical will feel insulted that the Slate does nut allow her to make up her own mind on whether ihe money should be paid into a joint account Bankers feel that there may be one other reason why Social Security officials may be luke- warm about introducing credit transfers: But the cost of disposing of cash is a small price to pay for the extra convenience for mother and pensioners. The objective of the Allied Hambro Pacific Fund is to obtain long term capital growth by investing: It enables you to invest in Singapore, Malaysia and the Philippines Ji a ve offered considerable potential for economic growth. Now a number of countries in this area huve begun to achieve their potential, and in recent years have shown remarkable growth rates, often twice that of many major industrialised countries. Until a few years ago political instability in the area was a major deterrent to investment. But while there is some risk of recurring political disturbances, the political climate, particularly following China's policy of improving relations with its neighbours, now appears more stable. At the same time, there is now within this area a. Oriom Ovmm Couninm Svtiru Pacdtr 1-ld. Swim TropotOoi Lid. V Wimor Industrial Corn. Malayan Banking fifed. The objective is to maximise long-term capital growth; income is not a consideration. The improving prospects of the area have already been reflected in rising stock market values during this year. While we consider that the prospects for growth will continue, you should bear in mind tbat investment in these markets con be subject to substantial short-term fluctuations. We recommend therefore that an investment in the fund should form only part of a balanced portfolio. That having been said, the advantages of investing in South East Asian marked through an authorised unit trust are powerful indeed, in terms of simplicity, convenience and spread of risk. An investment in the fund should be regarded as a long-term one. Remember the price of units and the income from them may go down as well as up. You should also note that currency movements can significantly affect the value of your investment. How to invest Investment opportunity To take advantage of opportunities to invest in companies operating in this area of potential growth, and to avoid the pitfalls, the experience of full-time. The portfolio 'is currently heing invested in the shares of companies quoted or operating in Hong Kong. Singapore, Malaysia and the Philippines, including companies registered in London or elsewhere which. You will be allocated units to the full value of your remittance at the offer price ruling on receipt of your application. Units in the fund may also he acquired on a Tegular monthly basis. For further details complete and return the coupon below, ticking the appropriate box. Uni La may normally be bought and nofel on any Lw mrUnK to. SeUlnff units. RtcUMit oAn u. I wish to invest Sifegiunlf. Thr Trvrtoe u! Chorees- The offer nricr cvmnll. The charge is currently lS. Xtuun appltatlicBi is granted, umtholden fat the bail will be asked to approve the anffopnatemerease. J declare that I am over 18 sod am not resident outside the UK or other Scheduled Tern tones and that I am not acouinna die above units es the. If you ere unable to malic ihe residential declaration it should be deleted and the form lodged through your UK bank, stockbroker or solicitor. This Offer is not available to residents of the Republic of Ireland. The Director nf Fair Trading. Gordon Borrie. It is also satisfied with the new regulations for the control of insurance brokers. Here it feels that There is room for chanses to avoid the quick kill type of sales, by spreading the initial commission over. The Department of Trade has been pursuing this same line with the LOA, which up tu nuw has adupted an air that all is well. The OFT states quite categorically that front rhe complaints it receives all is not well. But one word of advice to the OFT. If it analyses the source of complaints closely, it will most likely find that the main offenders are the sales forces of life companies that are not members of the LOA. And if the experience nf the Prudential, the Pearl and the Co-operative are anything to go by any proposed change in com- mission is likely to be. These companies, mem- bers of the LOA, wanted to. It took a long time and a hard atrugste to implement the change. Rise in Gross Domestic Product. The other i? This is a good time to invest in the Fund. Remember that the price of units and the income from them can go down as well as up. Investment in a unit trust should be regarded as long term. To invest simply fill in the coupon and send it to us with your cheque. A final point. He will tell you that few unit trust groups can match Allied Hambro for its Far Eastern expertise. He will also explain the fundamental investment factors which make the Pacific area so attractive today. Units will be allocated at the offer price ruling on receipt of your application. For your guidance, on 23rd October at an offer price of The Trust Dnad empowers the Managers, lo include an inriial service chnrgeo! You may sell all or patrol your unit holding back TO the Managers at not lese than the bid price. You will bo sent a cheque in uttlenunl within seven business days of receipt by the Managers of your renounced unit certificate 5 Managers: Rayleigti Raid. Telephone orders to Ol 2S51 or Brentwood MR, MRS. In addition: The right financing package The balance of dollar premium and loan, components of the Trust will be regularly reviewed sothat the unit price reflects portfolio performance as closely as possible. The gross yield is cow estimated at 2. They also have long experience of fund management mNorth America. You can buy units by completing the application form and sending it with your cheque for the arnountyou wish to Invest. You will be allocated units at the price ruling when, your application is received. We will send you a contract note within a few days tellirfcyoa the number and price of units allocated. You can normally expect to receive the certificate -within a month of purchase. First distribution will be on 30tfa April Vfi9. Units may be bought and 3 nld at the prevailing oBer and bid prices, and yield, which are published daily in leading nev. The offer price of units iroimjff. To seQ your units, simply return your certificate endorsed on the bar k. You will n? The management company is Craigmount Unit Trust Managers. The Bank of Scotland, The Mound. Edinburgh is the Trustee. Registered office: A number of those shares - AMI and whose owner is unknown. Then future date to be agreed. Do the documents which you might not have involved go to a central office? What would redemption — an application for happen If the local authority a search of the tithe map might compulsorily purchased yield a past owner's naxue. I have a right of way over my neighbour's land. Surmics MriMrsCvIbo. I jnvweare o' , or IS. Is there any yardstick for h, k h ,. The mortgagor bor- cent and 99 per cent based on rower should retain only a rateable values. The landlords copy of the mortgage deed. What can one do please? Y ' T There is no such yardstick as. Self- thmk that your points fa help mav prove a false economy. The local ' No fejol aiso be lodged with you or your it as an obstruction to your by position; techhicaliy to pursue agent. The mortgagor bor- right of way. There is however? Independent attitudes survive ;: IN5sO arise. The landlords have no catioa is still flourishing having power to prevent the tenants survived more or Jess intact the forming an association. But very 5. Howard,' ft. These limited results flated from the effect of the over Not unexpectedly, die. ORS groups made use of -the indepen- dent sector for the education of their children. Last week, lead- ing school fee specialists C farms. This means that both preference shares and Government securities are attractive investments for two important reasons. Firstly they offer a high immediate income. Secondly they offer scope for capital growth since the strengthening of sterling and continued economic recovery should reduce the general level of interest rates over the coming months. In order t to obtain consistently high income most T of the portfolio is invested in preference I shares but the. K when compared with direct investment in r these, securities.. The price of tatiu and the income from them can go down as well as up. Unus will be available after the offer doses at tbe nor- ms! Commission of ii? An initial charge of j? ContracrooceswiD be issued and unit certificates vitlbe forwarded wnbiB six weeks of payment. Managers Henderson Unit Trust. Q-N Registered Office. Your income will- be paid half-yearly At the end-of the. It- fs she. Higher Rate taxpayers may have their liability to tax reduced, deferred or. The Company reserves the right- to discontinue or revise the terms quoted in 'the light- of future investment conditions. After the close Scheme piwidea a tygPjf of this offer units will be available at the daily quoted price. The tables show how this is being done. Private education is not exclusively for the rich. Many families not only are prepared to make financial sacrifices, they are actually making those sacrifices- Families can help to meet l. D P TIQ. I am over 18 yean of age and understand that this Applica- tion Form shall be the basis of the. Insddi type of -: Think of the garden iigh- speed saving or the overs You invest in a tor could expect to receive [root: So the contribution scheme compared " thcr your tax bracket. The projected pay land Revenue. Not only is ly ten years membership of a tbe investor paying a greater - heme: The com a tax-free lump sum is pany passing on the benefit or owed to anyone with 20 years' investment in a tax-exempt "mbership. But there are drawbacks. Once an investor has paid the contributions the money cannot be touched until he retires or until his death, if earlier. He cannot use it like a building society account. The investor may not be aleb to take the a ,ch year of sen - ice. Consider Die case or a man ced 45 joining the pension heme. He will qualify for But he is lowe dthe maximum i-ommuta- on of one-and-a-half times finaJ Jaiy. And the cash sum. It depends very much on whether the amount exceeds the limits Tor commutation. It is a Revenue con ditidn that contributions should be paid for at least five years or until ' normal retirement ' if earlier. Overall contributions are limited to 15 per cent ; of salary, including what the mem-: And the scheme has to be established by the employer. Most employers, even those with seif-administered schemes, prefer to provide voluntary contributions through a life company. It is administratively simpler and avoids the prob- lems of setting up a separate in- vestment fund. A bewildering variety of schemes is at present being marketed. Life companies do their best to explain hu utthese schemes work, but with varying degrees of success. However, the Society estimates that because the investment is tax-free, the value of units will be more than double the amount of net premiums paid over ten years. So far, it has performed much better than this. For further details,- please fill in the coupon below: Julian Gibbs Associates Limited. Start to buy all iWe to normally insured perils. I oca 1 nurse ry and you do need buildings and their contents "outbuildings" — separate you may not have any buildings to cou t this price in your total subject to the adequacy of your garages, greehouses. These sums insured. But if your green- sheds and so on. Have a look houses or sheds that you your- particularly when you add in and not a loss for which you ai any of the weekly gardening self have installed, unless you the price of the flowerpots as -can expect insurers o pay. Those who take advantage of Roya! Trust's services need never fill in another tax form, and can rest assured that they're never E: All assessments will be automatically checked and all available reliefs claimed. Ring Bill Coid son orPieter kunz on S or alternatively, return the coupon below. We'll shun you how to save yourselfa lot of time and worn: And, possibly, a good deal of money as well. Name Address. We wanted to find out what personal investments they held; what these investments gave them; and how well they matched their expectations. The results were alarming. Ourresearch shows clearly that you want your capital to grow, with a minimum of tax liability. You want to be able to get atyour money fast whenever you need iLFrequently, you also want a regular income from it- taxfree. The majority of people we spoke to, however. In addition, many of the investments also held to seek capital growth required considerable skill and a good deal of time, which they could not afford, to manage successfully. To higher rate tax payers, it ca n be equivalent to twice that or more. In addition, it is part of the intemational. It is acknowledged internationally to be one of the leading investment houses in the countiy. It invests your money in a combination of no less than five other funds covering property, GK equities, international investments, fixed interest and gilt-edged stocks and short-term deposits. The balance of this investment mix is altered continuously to reflect changing market conditions and opportunities. This is how yourinvestment receives the same quality of investment service provided to those with millions of pounds. We pay the postage. Your money will then buy units in the Managed Fund at the offer price ruling on the day we receive your cheque and we will send you your Bond document showing the exact number of units in your Bond 1 To: London WBR. Are you in good physical and mental health and free from the effects of any previous illness or accident? If not please give details. Hf Registered No. Birmingham, has been so r great. And especially so if he was interested in a Ford. The panel of: When they did their rounds on Press day. This year's entries were from Western Europe. Soon 1BC. U1 — some may think belatedly — will consider wheilier or not to open the contest a: There arc live categories for cars— saloons, estates, hatch- MQTGE CASS backs- limousines and sports models — plus a couple for motor caravans and one for special bodywork. Other categories which hardly concern the motorist are for vehicles ranging from mini-buses to tractor cabs, juggernaut trailers to double-deckers. As a motoring correspondent, my judgment of a car has always been based more on the way it goes than the way it looks. Sorting out the cars most deserving of gold and silver awards from exhibits standing still or at most re- volving on turntables demanded new criteria. Judging a car objectively when it t; out of its element is curiously difficult. Taking account of general exterior and interior design and finish is fairly straightforward. But general visibility, accessibility oi controls and, above all, com- fort. If you havs a fine classic or collectors car allow us to show it to over 2, prospective purchasers and realise its full value. Over cars expected, these will include: Be sure to request your entry form today, victoria and Co. Telex 8S Demonstrators available. Always 20 guaranteed used models in stock. White; L. Thuraan Holland. Pirc Defence. Results were N-B3: Yugoslavia and o? H 4 PJW ivmes, in tnai year, are the material loss. Obly Fischer among f! For Miles. Spassky in his toe used. Moreover, if the challenger manages to achieve' all this and beat Karpov at the end of -It, there is still a return match clause IS months later. Ribli, IBM potential challenger k that. Umre Amsterdam Was it players who. Spassky— -when It would have been most Interest- ing. Chess Is virtually unique as a game where practically all the international play is th the form of tournaments but the world title is decided by 1 a match , at long intervals. Chess grand- masters are rarely -at their peak for more than a decade , and so the opportunities -are too few, it is really time the. Even if you cram loot with goodies like baked is. British ledonian will introduce cing s on its. Farewell to the ie-elevcns. While the Canaries in general Balearic; and. Mcon Villas a wide choice in 31al la. Paul's Bay. I adore the Algarve at any j, 5,-w. These all. Lan- Paphos, the port which dates and Exchange Travel explain in fater J? Special terms io companies. Details and ilhisl rated brochure or request Tel: Frcnthl hllchC' Bjr. Phone , 01 lB': J1 2a 'I Swimmlne pool. Caribbean Corny cti on. Parker Road. Kent TN14 70 B. Mask of. Magic of Sardinia Ltd.. MedoUfon- Holidays, Edgware Rood.. Loudon W2 2DS. Mcon Winter Holidays. OSfc House. Seietire has id.. Tinii,-d ih. Ho Long Months of Waiting. Remits brpln inimediaiely. Lift- DJuamirs ivrh nuiues oCcr sclf-masiery wuhoin sell- taenfife. Papers arc set for: Girls who will be under 32 years on 1st September. Girls who will be under 13 years on 1st September. Girls who will be under 14 years on 1st September, In addition, either one of two Music scholarships of the same value may be awarded annually to girls of any age. Miss V. All levrh. Leclere - Villefranche-uir-Mer - Tel: Part Ldnr. London W1 on Tuesday. To re. By Order cf the Board P F. Roe Secretary 27 October Notes Only members holding fully paid Ordinary shares, or their duly appointed rcDrcsentatim. A member so entitled may appoint a nrovr. EcaR sea -5 ffy. Other Euro- foreigner. On a good day in buyers are telling our nego- eussion recently about by how rate controversy. John's Wood. X may own a thriving The attraction still conunues waiting to buy. X may own a thriving The attraction still conanues waiting to buy. British Ley- because of other factors. The houses and flats to get the fteel slower rate of growth. Ready St John's Wood Hampstead and of selling blight. So in land and the coal miners strike, "invaders" were treated of the city and decide on the to move into properties are the surrounds mean nothin'- to prices leaped upwards surpass- the pound staggers, inflation is exactly as that. London was a best place to buy. Your local of a three day week looms. John's Wood or conductors excepted. His business is failing; the buyer changed all that. If Mr. Y Stores became multi-lingual, influenced the market. NWS 4 Beds. NW3 5 Wellington Ct. Stephens Cl. James 5q. Mawes have received Instructions to sell what must be one or the most distinctive properties In St. Mawes in south-west Cornwall. Known as Trewithit, it enjoys a superb situation with views across the Fal Estuary - to Pendennis Head. It has a ducted oil-fired central heating system. Toler- unsaleable. The explanation flowering carnations for ex- oeoo That was the situation, plants. A beV y of buyers chasing of virus infections. Inemi noiiori hv. It infects a great actual losses caused by vtruj it. It varieties as well as seeking? They systemic insecticides In fact, care to experiment carbendawm: And, of course, battle cry of the front line Great faith was placed on the one corollary of this was that vendors was "find me a rich meristem method of prnpaga- any treatment that merely Arab". This was an anomalv tion 3 fe w cells excised suppressed the symptoms with- in itself as the majority of over- from ll,e fast-growing tips of out eliminating the virus was seas buyers probabiy came sh? The old story of. Peterhead 8 miles Aberdeen 28 miles. Oil Central Heating. Planning permission applied for hotel and extension. G0 per acre In all about 5SS. Let on single Agricultural Tenancy dated February 1. On Wednesday, 22nd November, , at p. Subject m Reterwo. Liverpool 2. A M Cl Magnificent villa situated in its own beautiful seven acre grounds, superb views to Nice, Cannes and the Mediterranean. The house which will accommodate up to 20 people in great comfort, has 10 bedrooms. Two additional cottages in the grounds. The property is for sale with all its quality furnishing at a substantial price. For further details please apply: Thu is the ideal location for chose seeking die best of both worldi. Diane Steward Tel: Excellent swimming— warmest salt wacer. Formerly supported three farms. Chartered Land Agena. Lemon Villas. Truro Tel: South Coast and St. Viewi to the sea oeer otatefuf wooded parkland of S4 acres. Suitable far prime occupation, institutional use or conversion into fiats. Histone I4ch Century buildina at present subl-ng for conversion. Far required Tr crivaie l rr. The newly built: It has 2 conference rooms and a grill restaurant The hotel is centrally situated, but in a secluded spot The hotel is for sale and a quick settlement is wanted, Bergen has rich traditions in tourism and business travel. Would interested buyers please. Tgtotlan, IrtvesUnem areas. HIKpo Home. Honmd Lana. These are ideal for sending to rela- tions and friends at home and overseas, as well as for your own discerning enjoy- ment DEPT. Strum pihaw, Norwich Tel: Telex-- Hampers. Colour brochure on request public notices. Edlnbuntti EBiraR. They make marvellous presents.. Since I last wore about them they have added: I'm convinced, is an art and some penple arc much better at It than others. The old cliche about it being the thought and not the cost that really matters is. Even quite ordinary items like stationery, key-rings, cuff-links, can be transformed into something special if enough imagination and care has gone into choosing them. The one thing they all require is some advance planning. You really must order now if you want to he sure of them being ready for Christmas. You can send a photograph or the message to Sylvia's and they will be dealt with by mail of, alternatively they can be done while you wait. Some people ask for logos, letterheads, others like loving messages. They could be a good addition to a Christmas stocking. Cyril Came and Son, Wentworth Avenue, London N3 do several of the usual personalised items track-suits, towels etc but have recently introduced a nightdress rase which looks quite pretty. In red. Orders take about three weeks. Stephanie Roberts dues very beautiful batik w'ork on silk and can produce scarves that are very distinguished and very individual. She can make scarves of any and every colour except black and you can order them with a name in one corner or with the name used as the motif going right round the whole scarf. There are several sizes. The silk is very fine, the batik work exquisite and you can virtually ask for your own coiourways or design. The pies roust be large— 13 lb, b or 30 Jb. Orders will take about 10 days. Box 19, Swindon. If yon know a golf fanatic Kaleidoscope can also provide a pair of hallmarked sterling silver ball-markers engraved with up to four initials apiece. They are supplied fn a little leather carrying case. Portraits by Care! She loves working in quilted and padded satin which she often prints with her own rather special flowery designs. She has now devised a series of special white polyester satin hot waler-hottle covers and these can be ordered with any special Dame or theme in green, yellow, fuchsia, purple or blue. Special orders can be made to Fitzroy Frag the name of Rose Elliott's company. Box , 4 Reckitt Road, London W4. When ordering you should include your phone number as Rose Elliott may like to consult you about colours or 'other details. She will also send a list of different types of script, flowers or whatever else you would like included in the design. Orders should take up to three weeks. The bottle You must specify whether it is to be 11 ins. There is a choice of four different sorts of canvas 12 holes to the inch is the most popular. The Needle- woman Shop of Regent Street can give advice about choosing. It looks to me quite difficult to do in that although the full-colour photograph 'Is printed on to the canvas there are no absolute directions over which colours to put where and bringing human features to life is not easy. Needlecraft, 60, Holmes dale Road. Teddington, Middlesex. Delivery is about four weeks. Make sure that the print you send is clear; jf necessary cut out irrelevant details in the background. The designs are all, naturally enough, on racing themes, and I suppose on the assumption that racing circles are well-heeled, the prices are not low. V V ViT. MOST of us tend to think that commissioning portraits or sculptures is the province of the very rich or of grand com- panies which want to honour their distinguished presidents. Not many people realise that it is easier, less daunting and Jess expensive than they might imagine to have carried out either a portrait or a sculpture of either themselves or some- body they are fond of. The most reasonable method that I know of unless you have access to an Impecunious and talented future Augustus John is through two organisations that specialise in sifting both artists and potential clients, thus eliminating all the embar- rassment of being face to face with an individual. The National Portraiture Association. Surrey, is a registered charity which uses its funds to support scholarships and it has thus persuaded about 50 distin- guished artists to contribute their services, at reduced fees, in order to benefit the charity. In the past he has designed gravestones, com- memorative plaques, alphabets, exhibition pieces, glass bowls and medals. The fees charged have varied very little since I last wrote about the association nearly four years ago and the method for initiating a commission is much the same. Anybody inter- ested in having a portrait done should write to the association,, at the address given above, enclosing a 9p stamp, and they will then receive a brochure listing all the fees and the different mediums available chalk, pastels, oils and so on. From the illustrations enclosed in the brochure the potential client chooses the kind of style that most suits his taste and from there he can proceed with a commission. They include some very illustrious names like Michael Noakes almost every member of the Royal Family seems to have sat for him. The only artist of whom X have personal experience is Frances Baruch who has just completed a head of my daughter photographed above. She works from home at 16 Clifton Hill, London. NWS, and she works very quickly — she likes between four and six sittings, arranged very close together. She has most recently sculpted one of Sir Georg Solti's children and many other eminent people besides. ALMOST all good-class stationery shops and department stores have an excellent selection of writing-paper with initials incorporated somewhere into the design. Harrods, too, have a good stationery department and this pack of 15 monogrammed note cards, each In cream and navy border with gold letter, is accompanied by cream envelopes lined with navy bine. They will also send by post for 55p extra. The Yeoman gate illustrated is one of our range of craftsman made timber gates, constructed to give prolonged service. Other attractive designs are also available for the garden or farm. Sond 7p far a brochure or vtait m u Blddenden. Height Avt, table in antique shades ot green, red tan or dark raw lor order lorm. Mainland appro,. They have both been Deraarc ation lines and union requests and disc shows with Mr. U tries to leave som p d ne Peter Witt. Everyone tends to do nausic-on-ta: It has. Studio Piano-sirurummg musicians who prT , duC4fd by Mr. Three Force John's have been associated for anthems and the Funeral Sc a few musical seasons now, gen- traces all dating from the co orally mixing ancient and mod- poser's early twenties or befor - ern with fine artistry but, one were preceded by music from t gathers, not too good a response previous generation with whi at the box office. Their new he would have been famil. George Jeffries' v: Osnabrfick, where with each other. Why not. Havms spent Much of the time the station is H US,? In this case. In Nottingham they are engaged on various multi-racial projects. In Derby they have ventured abroad to broadcast programmes from their twin town in Germany. Davis, Joyce Blair and Leonie Cosman. What Derby last Friday when I was the BBC alms to offer is the piere rated more than a few choice between listening to one inches in the national Press but of five services, four of them they were all of major lraport- Network Radios 1 to 41 and one ance to this community: Billy full-blown musical. Anthony directed by Kenneth Chub, at: Quayle, a tough old Lear, should dishonesty in human relat: Ushers Carlin Music who are It will have an all-American cast not be missed. Reviewed Wed- ships. Reviewed Friday. A group of is already arranged. Jesse and m the Rat! S usual here. Thursday, the Cot? Lunchthne hour Daunt. Could that be a about South African politics, set Outside central London, ths a headc air about the studios was a good morning for the Solution to Problem No. E ment as the sline and pebbles mine when a big national storv K-B5: K- about how their shows are musical's cause. Witt is other. The best one I ever made safest recommendation since the latest antics of The Petr. Battles have been fou"ht here breaks io the area. He aware that many British Jews, was as an agent Would you Sleuth. Hypnotic play bv ton: T u ae wnn! Not from Matt; 1 1 though there are many vana- refugee from Nazi Germany alter a long fight and the com- it might have been. When Jarvis Mr. Steve Kulukundist. Witt gave him ail j ded. Jason Ro bards. Lauren Mr. Win prefers to have pro- the appropriate assurances and, elude that the primary aim will sections. For Bacall and Eli Wallach. Football Focus Boxing 1. Motor Sport World Gymnastics Champion- ships t Wales — 8. Scotland — 1. Northern Ireland:.

Using a regression model, it is analyzed the impact of the educational and health capital on the economic output. In the paper, a linear regression model of the relation of human capital to economic growth is subjet of an empirical analysis, firstly, taking into consideration only education as human capital and secondly, incorporating in the model the both components: A strong correlation between educational variables and GDP, forwas found.

The quality of the educational capital has a determinant role in the economic growththe highly educated people are influencing more the economic output than the secondary educated ones. GDP per capita is negatively correlated with the number of worked hours and positively influenced by the life expectancy. The most important contribution contained by this article refers to the incorporation of the two components of human capital in the same econometric model explaining the economic growth.

The added value of paper consists in offering suggestions and orientation for national educational policies. Human fetal click to see more is constrained below optimal for perinatal survival.

Vasak, B. ObjectiveThe use of fetal growth charts assumes that the optimal size at birth is at the 50 th birth-weight centile, but interaction between maternal constraints on fetal growth and the risks associated with small and large fetal size at birth may indicate that this assumption is not valid for. Abstract The development of a country usually determined by the human development index HDI. Per capita income education and health are the three most important components of human development index.

The purpose of this research is to understand the relationship among human development index to income per capita growth and poverty alleviation in Indonesia with cross-section data from 30 provinces period year. The result of this research were a income per capita growth was not sign Human corpus luteum: Epidermal growth factor receptors are present in many reproductive tissues but Rin aoki porn etotic clips not been demonstrated in the human corpus luteum.

Link determine the presence of epidermal growth factor receptors and its binding characteristics, we carried out studies on the plasma cell membrane fraction of seven human corpora lutea days 16 to 25 of the menstrual cycle.

Specific epidermal growth factor receptors were present in human corpus luteum. Insulin, nerve growth factor, and human chorionic gonadotropin did not competitively displace epidermal growth Rin aoki porn etotic clips binding. The optimal conditions for corpus luteum-epidermal growth factor receptor binding were found to be incubation for 2 hours at 4 degrees C with micrograms Rin aoki porn etotic clips membrane protein and femtomol I-epidermal growth factor per incubate.

In two regressing corpora lutea obtained on days 2 and 3 of the menstrual cycle, there was Rin aoki porn etotic clips detectable specific epidermal growth factor receptor binding activity. Similarly no epidermal growth factor receptor binding activity could be detected in ovarian stromal tissue.

Our findings demonstrate that specific receptors for epidermal growth factor are present in the human corpus luteum. The physiologic significance of epidermal growth factor receptors in human corpus luteum is unknown, but epidermal growth factor may be involved in intragonadal regulation of luteal function. Position stand on androgen and human growth hormone use.

Position stand on Androgen and human growth hormone use. J Strength Cond Res 23 5: S1-S59, Perceived yet often misunderstood demands of a sport, overt benefits of anabolic drugs, and the inability to be offered any effective alternatives has fueled anabolic drug abuse despite any consequences. Motivational interactions with many situational demands including the desire for improved body image, sport performance, physical function, and body size influence and fuel such negative decisions.

Positive countermeasures to deter the abuse of anabolic drugs are complex and yet unclear. Furthermore, anabolic drugs work and the optimized training and nutritional programs needed to cut into the magnitude of improvement mediated by drug abuse require more work, dedication, and preparation on the part of both athletes and coaches alike.

Few shortcuts are available to the athlete who desires to train naturally. Historically, the NSCA has placed an emphasis on education to help athletes, coaches, and strength and conditioning professionals become more knowledgeable, highly skilled, and technically trained in their approach to exercise program design and implementation.

Optimizing nutritional strategies are a vital interface to help cope with exercise and sport demands. In addition, research-based supplements will also have to be acknowledged as a strategic set of tools e. Resistance exercise is the Rin aoki porn etotic clips effective anabolic form of exercise, and over the past 20 years, the research base for resistance exercise has just started to develop to a significant volume of work to help in the decision-making process in program design.

The interface with nutritional strategies has Rin aoki porn etotic clips less. Growth kinetics of four human breast carcinomas grown in nude mice. Read article three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations.

In the present study one estrogen and progesterone receptor-negative T60 and Rin aoki porn etotic clips receptor-positive Br, MCF-7, T61 human breast cancer xenografts The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis Rin aoki porn etotic clips on fine-needle aspirations.

Rin aoki porn etotic clips results showed that the tumors had growth kinetics comparable to other Rin aoki porn etotic clips tumor types On the growth rate of gallstones in the human gallbladder.

The growth rate of a single symmetrically oval shaped gallbladder stone weighing The Rin aoki porn etotic clips of the stone source measured by ultrasonography and the growth rate Rin aoki porn etotic clips found to be linear with time, with a value of 0.

The morphology and metallic ion chemical composition of the large stone and of a randomly selected small stone weighing about 1. It was found that the large stone contained besides calcium also lead, whereas the small stone contained mainly calcium. It is possible that the lead causes a difference in mechanism between Rin aoki porn etotic clips growth of a single large and growth of multiple small gallstones. Full Text Available In the process of developing economy in a whole and continuously, the macro economy stability of acountry is an essential prerequisite for producing a quality economic growth.

For achieving the qualityeconomic growththere should be a continuous capital human investment and the use of continuousscience and technology IPTEK. The process of developing economy will be able to transform thesociety condition from vicious circle to virtuous circle condition if the growth of economy is qualified. Quality of growth ; human capital, technology and virtuous circle. Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor.

To determine if fibroblasts could be a source of fibroblast growth factor FGF in tissue, cells were initiated in culture from newborn human foreskin.

Fibroblast cell lysates promoted radiolabeled thymidine uptake by cultured quiescent fibroblasts. Seventy-nine percent of the growth -promoting activity of lysates was recovered from heparin-Sepharose. The heparin-binding growth factor reacted on immunoblots with antiserum to human placenta-derived basic FGF and competed with iodinated basic FGF for binding to antiserum to bFGF synthetic peptide.

To confirm that fibroblasts were the source of the Rin aoki porn etotic clips factor, cell lysates were Lebanan naked hot girls from cells incubated with radiolabeled methionine. Heparin affinity purified material was immunoprecipitated with basic FGF antiserum and electrophoresed.

Radiolabeled material was detected on gel autoradiographs in the same molecular weight region as authentic iodinated basic FGF. The findings are consistant with the notion that cultured fibroblasts express basic FGF. As these cells also respond to the mitogen, it is possible that the regulation of their growth is under autocrine control.

Fibroblasts may be an important source of the growth factor in tissue. Rin aoki porn etotic clips human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Human embryonic stem cells hESCs are thought to be a promising cell source for cell transplantation therapy.

For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin rhLM isoforms on the undifferentiated growth of hESCs.

The hESCs proliferated on these three rhLMs for several passages while preserving their pluripotency. We analyzed the Rin aoki porn etotic clips and function of p8 in pancreatic cancer-derived cells. Rin aoki porn etotic clips boobs gif. Human Development and Economic Growth. Recent literature has contrasted Human Development, described as the ultimate goal of the development process, with economic growthdescribed as an imperfect proxy for more general welfare, or as a means toward enhanced human development.

This debate has broadened the definitions and goals of development but still needs to define the important interrelations between human development HD and economic growth EG. To the extent that greater freedom and capabilities improve economic performan Growth charts of human development.

This article reviews and compares two types of article source charts for tracking human development over age. Both charts https://hotel.revia2018.host/video4157-gefipopod.php the existence of a continuous latent variable, but relate to the observed data in Rin aoki porn etotic clips ways.

The D-score diagram summarizes developmental indicators into a single aggregate. Energy, economic growth this web page, and human welfare.

The subject is covered in sections, entitled: The D-score diagram summarizes developmental indicators into a single aggregate score measuring global development. The relations between Rin aoki porn etotic clips indicators should be consistent with the Rasch model. If true, the Rin aoki porn etotic clips is a measure with interval scale properties, and allows for the calculation of meaningful differences both within and across age.

The stage line diagram describes the natural development of ordinal indicators. The method models the transition probabilities between Rin aoki porn etotic clips stages of the indicator as smoothly varying functions of age. The location of each stage is quantified by the mid-P-value. Both types of diagrams assist in identifying early and delayed development, as well as finding differences in tempo.

The relevant techniques are illustrated to track global development during infancy and early childhood years and Tanner pubertal stages years. New reference values for both applications are provided.

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It not only gives comparable results w. IL-8 had no effect. Epidermal growth factor and its receptors in human pancreatic carcinoma. The role of epidermal growth factor EGF in oncogenesis and progression of malignant tumors is a subject of vast interest. In this study, radioimmunoassay and radioreceptor assay of EGF were established. EGF contents in malignant and benign pancreatic tumors, in normal pancreas tissue, and in culture media of a human pancreatic carcinoma cell line were determined. EGF receptor binding studies were performed. It was shown that EGF contents in pancreatic carcinomas were significantly higher than those in normal pancreas or benign pancreatic tumors. EGF was also detected in the culture medium of a pancreatic carcinoma cell line. The binding of I-EGF to the pancreatic carcinoma cells was time and temperature dependent, reversible, competitive, and specific. Scatchard analysis showed that the dissociation constant of EGF receptor was 2. Human milk fortification strategies for improved in-hospital growth of Human milk is the preferred feed for preterm infants, yet it may need to be fortified for optimal growth and development. Standard fortification of human milk seldom meets the recommended intake of protein, leading to inadequate post-natal growth. This article aims to critically review different human milk fortification Developmental regulation of human truncated nerve growth factor receptor. DiStefano, P. Urine samples were collected from 70 neurologically normal subjects ranging in age from 1 month to 68 years. By using this sensitive two-site radiometric immunosorbent assay, NGF-Rt levels were found to be highest in urine from 1-month old subjects. No evidence for diurnal variation of adult NGF-Rt was apparent. Pregnant women in their third trimester showed significantly elevated urine NGF-Rt values compared with age-matched normals. These data show that NGF-Rt is developmentally regulated in human urine, and are discussed in relation to the development and maturation of the peripheral nervous system. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Human papilloma virus HPV types 16 and 18 are most commonly associated with cervical carcinoma in patients and induce immortalization of human keratinocytes in culture. HPV has not been associated with breast cancer. This report describes the immortalization of normal human mammary epithelial cells 76N by plasmid pHPV18 or pHPV16, each containing the linearized viral genome. Transfectants were grown continuously for more than 60 passages, whereas 76N cells senesce after passages. The transfectants also differ from 76N cells in cloning in a completely defined medium called D2 and growing a minimally supplemented defined medium D3 containing epidermal growth factor. HPV transfectants do not form tumors in a nude mouse assay. It is concluded that products of the HPV genome induce immortalization of human breast epithelial cells and reduce their growth factor requirements. This result raises the possibility that HPV might be involved in breast cancer. Furthermore, other tissue-specific primary epithelial cells that are presently difficult to grown and investigate may also be immortalized by HPV. Expression of the human growth hormone variant gene in cultured fibroblasts and transgenic mice. The nucleotide sequence of the human growth hormone variant gene, one of the five members of the growth hormone gene family, predicts that it encodes a growth hormone-like protein. The growth hormone variant protein expressed in transiently transfected L cells is distinct from growth hormone itself with respect to reactivity with anti- growth hormone monoclonal antibodies, behavior during column chromatography, and isoelectric point. Transgenic mice expressing the growth hormone variant protein are 1. Algorithmic complexity of growth hormone release in humans. Most hormones are secreted in an pulsatile rather than in a constant manner. This temporal pattern of pulsatile hormone release plays an important role in the regulation of cellular function and structure. In healthy humans growth hormone GH secretion is characterized by distinct pulses whereas patients bearing a GH producing tumor accompanied with excessive secretion acromegaly exhibit a highly irregular pattern of GH release. It has been hypothesized that this highly disorderly pattern of GH release in acromegaly arises from random events in the GH-producing tumor under decreased normal control of GH secretion. Using a context-free grammar complexity measure algorithmic complexity in conjunction with random surrogate data sets we demonstrate that the temporal pattern of GH release in acromegaly is not significantly different from a variety of stochastic processes. In contrast, normal subjects clearly exhibit deterministic structure in their temporal patterns of GH secretion. Our results support the hypothesis that GH release in acromegaly is due to random events in the GH-producing tumorous cells which might become independent from hypothalamic regulation. Clinical impact of biotechnology has been constrained by the limitations of traditional hypodermic injection of biopharmaceuticals. Microneedle patches have been proposed as a minimally invasive alternative. In this study, we assess the translation of a dissolving microneedle patch designed for simple, painless self-administration of biopharmacetucials that generates no sharp biohazardous waste. After manual insertion into the skin of hairless rats, hGH pharmacokinetics were similar to conventional subcutaneous injection. After patch removal, the microneedles had almost completely dissolved, leaving behind only blunt stubs. The dissolving microneedle patch was well tolerated, causing only slight, transient erythema. This study suggests that a dissolving microneedle patch can deliver hGH and other biopharmaceuticals in a manner suitable for self-administration without sharp biohazardous waste. Humanized versus murine anti- human epidermal growth factor receptor monoclonal antibodies for immunoscintigraphic studies. Morales, Alejo A. The mAb ior C5 that recognizes an antigen expressed preferentially on the surface of malignant and cytoplasm of normal colorectal cells was used as negative control. Among all organs significant accumulation was found in tumor 6. The immunoreactive fractions were found to be 0. Thus, we expect better results using the humanized mAb h-R3 for diagnostic immunoscintigraphy. The anti- human epidermal growth factor receptor EGF-R humanized antibody h-R3 IgG 1 , which binds to an extracellular domain of EGF-R, was used to evaluate the biodistribution on nude mice xenografted with A epidermoid carcinoma cell line. Immunoreactivity of 99m Tc-labeled mAbs was measured by enzyme linked immunosorbent assay on A cell line and the immunoreactive fractions determined by Lindmo method. Full Text Available In order to address the direction of causality between human capital and productivity growth in Nigeria, the study first investigated the pattern of productivity growth in Nigeria between and Following the endogenous growth model, which argued that technical progress, through an effective labor force, could lead to long-run growth which can be determined from within an economy; but it actually depends on the efficiency with which resources available to such an economy are utilized. This is against the exogenous growth model which emphasized that long-run growth can be attained by some unexplained technological progress, which is exogenous to any economy. Based on this controversy in literature, this study empirically determined the productivity growth in Nigeria, as well as the causal relation between human capital development and productivity growth in Nigeria using the Engle-Granger causality test. The results revealed that productivity growth has been very low and unstable in Nigeria as it oscillated between In addition, the nexus between human capital and productivity growth was examined. The findings revealed that while productivity growth caused human capital development, human capital development did not cause productivity growth. Metabolic clearance and production rates of human growth hormone. No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's. The MCR was relatively constant from day to day and within the day when subjects were evaluated in the supine position. These results were contrasted with the MCR of HGH observed in a small number of patients with altered thyroid function or diabetes mellitus. As growth hormone possesses anabolic properties that are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I IGF-I its specific binding proteins Mathematical modelling of the growth of human fetus anatomical structures. The goal of this study was to present a procedure that would enable mathematical analysis of the increase of linear sizes of human anatomical structures, estimate mathematical model parameters and evaluate their adequacy. Section material consisted of 67 foetuses-rectus abdominis muscle and 75 foetuses- biceps femoris muscle. The following methods were incorporated to the study: Size changes can be described with a segmental-linear model or one-function model with accuracy adequate enough for clinical purposes. The interdependence of size-age is described with many functions. However, the following functions are most often considered: The best adjustments to measurement results were observed in the exponential and Gompertz's models. The growth pattern of the human intestine and its mesentery. It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visualization techniques. We distinguished 3 generations of midgut loops. The topography of primary and secondary loops was constant, but that of tertiary loops not. The orientation of the primary loop changed from sagittal to transverse due to the descent of ventral structures in a body with a still helical body axis. The 1st secondary loop duodenum, proximal jejunum developed intraabdominally towards a left-sided position. The 2nd secondary loop distal jejunum assumed a left-sided position inside the hernia before returning, while the 3rd and 4th secondary loops retained near-midline positions. Intestinal return into the abdomen resembled a backward sliding movement. Only after return, the 4th secondary loop distal ileum, cecum rapidly "slid" into the right lower abdomen. The seemingly random position of the tertiary small-intestinal loops may have a biomechanical origin. The interpretation of "intestinal rotation" as a mechanistic rather than a descriptive concept underlies much of the confusion accompanying the physiological herniation. We argue, instead, that the concept of "en-bloc rotation" of the developing midgut is a fallacy of schematic drawings. Primary, secondary and tertiary loops arise in a hierarchical fashion. The predictable position and growth of secondary loops is pre-patterned and determines adult intestinal topography. We hypothesize based on published accounts that malrotations result from stunted development of secondary loops. Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis. Twenty consecutive patients with cirrhosis were randomized to recombinant human growth hormone Norditropin, 4 I. The serum concentrations of insulin-like growth factor-I in the recombinant No significant changes were seen in the area under the curve for biochemical liver function tests. We conclude that administration of recombinant human growth hormone induces This research postulates that prostate cancer cells commandeer this normal epithelial-mesenchymal signaling pathway to recruit stromal cells to support abnormal tumor growth and tests the hypothesis Potency testing of mesenchymal stromal cell growth expanded in human platelet lysate from different human tissues. Mesenchymal stromal cells MSCs have been largely investigated, in the past decade, as potential therapeutic strategies for various acute and chronic pathological conditions. MSCs isolated from different sources, such as bone marrow BM , umbilical cord tissue UCT and adipose tissue AT , share many biological features, although they may show some differences on cumulative yield, proliferative ability and differentiation potential. The standardization of MSCs growth and their functional amplification is a mandatory objective of cell therapies. The aim of this study was to evaluate the cumulative yield and the ex vivo amplification potential of MSCs obtained from various sources and different subjects, using defined culture conditions with a standardized platelet lysate PL as growth stimulus. MSCs morphology, phenotype, differentiation potential, and immunomodulatory properties were also investigated to evaluate their biological characteristics. The use of standardized PL-based culture conditions resulted in a very low variability of MSC growth. The adoption of standardized culture conditions may help researchers and clinicians to reveal particular characteristics and inter-individual variability of MSCs sourced from different tissues. These data will be beneficial to set the standards for tissue collection and MSCs clinical-scale expansion both for cell banking. Full Text Available It is obvious that human capital is critical for economic growth. The paper aims to investigate the relationships between human capital and economic growth in the romanian economy by analyzing the correlations between statistical variables measuring human capital and economic growth. Using a regression model, it is analyzed the impact of the educational and health capital on the economic output. In the paper, a linear regression model of the relation of human capital to economic growth is subjet of an empirical analysis, firstly, taking into consideration only education as human capital and secondly, incorporating in the model the both components: A strong correlation between educational variables and GDP, for , was found. The quality of the educational capital has a determinant role in the economic growth , the highly educated people are influencing more the economic output than the secondary educated ones. GDP per capita is negatively correlated with the number of worked hours and positively influenced by the life expectancy. The most important contribution contained by this article refers to the incorporation of the two components of human capital in the same econometric model explaining the economic growth. The added value of paper consists in offering suggestions and orientation for national educational policies. Human fetal growth is constrained below optimal for perinatal survival. Vasak, B. ObjectiveThe use of fetal growth charts assumes that the optimal size at birth is at the 50 th birth-weight centile, but interaction between maternal constraints on fetal growth and the risks associated with small and large fetal size at birth may indicate that this assumption is not valid for. Abstract The development of a country usually determined by the human development index HDI. Per capita income education and health are the three most important components of human development index. The purpose of this research is to understand the relationship among human development index to income per capita growth and poverty alleviation in Indonesia with cross-section data from 30 provinces period year. The result of this research were a income per capita growth was not sign Human corpus luteum: Epidermal growth factor receptors are present in many reproductive tissues but have not been demonstrated in the human corpus luteum. To determine the presence of epidermal growth factor receptors and its binding characteristics, we carried out studies on the plasma cell membrane fraction of seven human corpora lutea days 16 to 25 of the menstrual cycle. Specific epidermal growth factor receptors were present in human corpus luteum. Insulin, nerve growth factor, and human chorionic gonadotropin did not competitively displace epidermal growth factor binding. The optimal conditions for corpus luteum-epidermal growth factor receptor binding were found to be incubation for 2 hours at 4 degrees C with micrograms plasma membrane protein and femtomol I-epidermal growth factor per incubate. In two regressing corpora lutea obtained on days 2 and 3 of the menstrual cycle, there was no detectable specific epidermal growth factor receptor binding activity. Similarly no epidermal growth factor receptor binding activity could be detected in ovarian stromal tissue. Our findings demonstrate that specific receptors for epidermal growth factor are present in the human corpus luteum. The physiologic significance of epidermal growth factor receptors in human corpus luteum is unknown, but epidermal growth factor may be involved in intragonadal regulation of luteal function. Position stand on androgen and human growth hormone use. Position stand on Androgen and human growth hormone use. J Strength Cond Res 23 5: S1-S59, Perceived yet often misunderstood demands of a sport, overt benefits of anabolic drugs, and the inability to be offered any effective alternatives has fueled anabolic drug abuse despite any consequences. Motivational interactions with many situational demands including the desire for improved body image, sport performance, physical function, and body size influence and fuel such negative decisions. Positive countermeasures to deter the abuse of anabolic drugs are complex and yet unclear. Furthermore, anabolic drugs work and the optimized training and nutritional programs needed to cut into the magnitude of improvement mediated by drug abuse require more work, dedication, and preparation on the part of both athletes and coaches alike. Few shortcuts are available to the athlete who desires to train naturally. Historically, the NSCA has placed an emphasis on education to help athletes, coaches, and strength and conditioning professionals become more knowledgeable, highly skilled, and technically trained in their approach to exercise program design and implementation. Optimizing nutritional strategies are a vital interface to help cope with exercise and sport demands. In addition, research-based supplements will also have to be acknowledged as a strategic set of tools e. Resistance exercise is the most effective anabolic form of exercise, and over the past 20 years, the research base for resistance exercise has just started to develop to a significant volume of work to help in the decision-making process in program design. The interface with nutritional strategies has been less. Growth kinetics of four human breast carcinomas grown in nude mice. The three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations. In the present study one estrogen and progesterone receptor-negative T60 and three receptor-positive Br, MCF-7, T61 human breast cancer xenografts The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis performed on fine-needle aspirations. The results showed that the tumors had growth kinetics comparable to other human tumor types On the growth rate of gallstones in the human gallbladder. The growth rate of a single symmetrically oval shaped gallbladder stone weighing The length of the stone was measured by ultrasonography and the growth rate was found to be linear with time, with a value of 0. The morphology and metallic ion chemical composition of the large stone and of a randomly selected small stone weighing about 1. It was found that the large stone contained besides calcium also lead, whereas the small stone contained mainly calcium. It is possible that the lead causes a difference in mechanism between the growth of a single large and growth of multiple small gallstones. Full Text Available In the process of developing economy in a whole and continuously, the macro economy stability of acountry is an essential prerequisite for producing a quality economic growth. For achieving the qualityeconomic growth , there should be a continuous capital human investment and the use of continuousscience and technology IPTEK. The process of developing economy will be able to transform thesociety condition from vicious circle to virtuous circle condition if the growth of economy is qualified.. Quality of growth ; human capital, technology and virtuous circle. Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor. To determine if fibroblasts could be a source of fibroblast growth factor FGF in tissue, cells were initiated in culture from newborn human foreskin. Fibroblast cell lysates promoted radiolabeled thymidine uptake by cultured quiescent fibroblasts. Seventy-nine percent of the growth -promoting activity of lysates was recovered from heparin-Sepharose. The heparin-binding growth factor reacted on immunoblots with antiserum to human placenta-derived basic FGF and competed with iodinated basic FGF for binding to antiserum to bFGF synthetic peptide. To confirm that fibroblasts were the source of the growth factor, cell lysates were prepared from cells incubated with radiolabeled methionine. Heparin affinity purified material was immunoprecipitated with basic FGF antiserum and electrophoresed. Radiolabeled material was detected on gel autoradiographs in the same molecular weight region as authentic iodinated basic FGF. The findings are consistant with the notion that cultured fibroblasts express basic FGF. As these cells also respond to the mitogen, it is possible that the regulation of their growth is under autocrine control. Fibroblasts may be an important source of the growth factor in tissue. Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Human embryonic stem cells hESCs are thought to be a promising cell source for cell transplantation therapy. For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin rhLM isoforms on the undifferentiated growth of hESCs. The hESCs proliferated on these three rhLMs for several passages while preserving their pluripotency. We analyzed the expression and function of p8 in pancreatic cancer-derived cells. Methods Expression of p8 was silenced in the human pancreatic cancer cell lines Panc-1 and BxPc-3 by infection with a retrovirus expressing p8 RNA in the antisense orientation. Cell growth was measured in control and p8-silenced cells. Influence on p8 expression of the induction of intracellular pathways promoting cellular growth or growth arrest was monitored. Results p8-silenced cells grew more rapidly than control cells transfected with the empty retrovirus. Conclusions p8 inhibits the growth of human pancreatic cancer cells. These results suggest that p8 belongs to a pathway regulating the growth of pancreatic cancer cells. A comparison of fatigue crack growth in human enamel and hydroxyapatite. Cracks and craze lines are often observed in the enamel of human teeth, but they rarely cause tooth fracture. The present study evaluates fatigue crack growth in human enamel, and compares that to the fatigue response of sintered hydroxyapatite HAp with similar crystallinity, chemistry and density. The specimens were subjected to mode I cyclic loads and the steady state crack growth responses were modeled using the Paris Law. In regions of decussation, the microstructure promoted microcracking, crack bridging, crack deflection and crack bifurcation. Working in concert, these mechanisms increased the crack growth resistance and resulted in a sensitivity to crack growth m similar to bone and lower than that of human dentin. These mechanisms of toughening were not observed in the crack growth response of the sintered HAp. While enamel is the most highly mineralized tissue of the human body, the microstructural arrangement of the prisms promotes exceptional resistance to crack growth. Mi rv: If-, rights with tin. Scandinavian Airlines istarled. All have refused. The original intention two years ago was that the VW plant would assemble up to B r E nioim day. Sheldon brought a flood of applications from companies tickets for their Yesterday British Rail said that the statement accelerated a process which started about three! Plans are already being creases. Sir Geoffrey Howe, month. Conservative earlier thLs i. He made it clear, however, that he believed Arm. He preferred to stress freedom from government inicrferenci? John Paraue. Pardoe said Britain had 1 1 pea n bu- again. Lf we did not join Government in a difficult uur partners iu the system in linn. A Commons debale the New Year we would be been promised on the Euro- forced sooner or later to accept a Monetary System when a a i-mninan currency fashioned by siun is taken in December others. John Collins, managing director of Park West Motors, [ford. Essex, which imports Toyota cars, was delighted, if not a little surprised, by ihe news of ihe loan which will enable him lo buy xi new garage and. The corporation was 3 little coy about the deal. This, departure mla imports financing was iustjfled largely on the hasis of Mr. Collins be-. Collins did nut import Tuyotas. It said: Coilins said that when he applied for the loan he had expected the nature of hfs trade to be a problem. Finance had been difficult to find, but. Peter Foden-Pattin-: Conservative sun. Minet Agencies, and for Thanei East, about the Mr. Confidence was also expressed m Mr. Bernard Wex. The dispute over productivity is to be ihe subject of talks with Mr. It has also been the cause of warnings by the construction company that if payments con- tinue- to he withheld it might be forced to abandon the pro- ject, which. British Bridge Builders ruled twu weeks ago that if the Free- man Fox targets were not met the cable spinners would lose bonus payments equivalent lo about one third of weekly earnings. Haydon Glen, clerk to the Board, said that outstanding issues in the dispute would have to be- settled by arbitration or in the High Court. British Industry indicated last The campaign was formed in night that ii took seriously pro- response to a Labour document, posals by sections of the Labour suggesting a National Construc- Party for nationalisation of the tion Corporation on the lines of building industry. Erie Heffer, thai Labour should argue for step-by-slep public ownership of the construction industry. However, the Labour Party planned nationalisation. Water workers. The employer f had to provide the season ticket years ago and most annual sea- son tickets were now bought. Lins it Dispute delays frigate launch which would not be cashable by the employee, and he could not reimburse him for a ticket already bought. The frigate represent a key public sector Brilliant was to have been group in the low-pay area which launched next week. British Finally, the employee's earn- Mr. The Inland Revenue said yesterday that additional qualifi- cations. And it was likely most of the Discussion ranged round im- proving productivity by natural wastage. The management is stilt seeking to reduce the labour force by several thousand. Talks on this are At yesterday's meeting of Iho expected to take weks. The question of what cate- gories of workers make up ihe grades — and their rates — has stili not been settled. Saturday night shift, it added. Heffer was ownership, as the TUC had pru- addressmg. TASS, the engineering sluff union, yesterday issued a strong denial of charges reported to have been made last weekend by Mr. Michael Edwardes. BL chairman. TASS national lift. He Is ton. Rudolph Agnew, deputy chairman, said yesterday that the study would be finished in a matter of weeks. The venture would be on a small scale, producing less than half the amount of tin -of Wheal Jane, near Truro. Wheal Jane had an output of That mine is now on a care- and-malatenance basts after production. Robert L. Sprinkel— bis reluctance to accept Government money and the fact that he is willing tu put his own money ih, H Said Lord Erroll of Hale, the ehairman. Bat he held to the basic Gold Fields position on Wheal Jane: Bnt Lord Errol! As far as other Cornish activities are concerned,. Gold Fields is evaluating the results of drilling at two neglhbonring sites. ICI said yesterday that it did not yet have firm plans for the site, but it could follow the pattern of its biggest petro- chemicals site at Wilton on Teeiside. Products could include ammo nia and methanol— derived from natural gas — as wel-1 as oiher basic petrochemicals and down- stream products such as plasucs and fibres. It is also involved in exploration pro grammes on various parts of the UK continental shelf In the North Sea and to the west oF the Shetlands. It has developed more than 1. Il is thought however, that ICI is anxious not to concentrate its resources too heavily In one area. It has carried out land and seabed surveys at an estuary site in Tayside, Scotland. The site is at Barry Buddon. The company is also under stood to have investigated the Humber estuary in England. Both the Humber and Tay offer sites with fiat land and access to. The com puny has held a series of dis- cussions with the Scottish Office shout the Tayside location. First news of the plan has already brought mixed reactions from local interests on Tayside. Dundee has high unemployment It might therefore be expected 3 hili 1 in spa,n - The deposit certificates trial. He was jointly charged. Felicio Morelia, the former Banking Corporation and its head of both international Bank, associated company, European ing and European and Arabian, and Arabian Bank, both regis- who was jailed for three years tered in Anquilia. Unterlaggauer has prison sentence at the Old Bailey, spent 12 months in custody, he Dr. Heinrich Peter Unlertag- will be released on Honda when gauer, born In Austria, had a riepnrtatinn order will be con- pleaded guilty to charges of issu- sirlcrert. He claims io have a ing false certificates of deposit job awaiting him in Germany, in order to acquire seven hotels Mr. Joseph Khalife is still on in Spain. The deposit certificates trial. He Detective Chier Inspector Roy has pleaded no't guilty-. Elsey, he admitted signing 15 European and Arabian Bank certificates — together with has no connection with the another former employee of European Arab Bank group International Banking Corpora- Industrial Banking Cornoration" non who has since left the UK. Uo terlaggauer's sentence the c ame name. EG Commission to make their eipalities: Most of the steel in an average British car body is sheet steel. There was little to cheer in the silt market either, as a further rise in U. Interest rates British interest rates are still high enough to attract inflows from the United States, even after the most recent rise in the U. As the forward discount on ster- ling has shrunk almost to par. On a simpler level, it does seem that confidence in sterling, as against lack of confidence in the dollar, has been growing over the last week, with the foreign exchange markets appealing rather less worried about news on the labour front. There has been some nervous- ness i hat the Bank of England might intervene to stop sterling rising fun her. Next week the official cur- rency reserve figures for October will be published, and they are expected to show that the Bank's intervention has been limited. But any sign aF funds flowing heavily into London could be worrying to the markets, unless of course foreign money flows into gilts and encourages the home-based institutions tu jump in too. At the moment, though, short money rates are so high that they weaken the inducement to commit money to gilts. Drug problems Beecham's share price took a rumble last week on news that the company may bo forced to cut its drug prices further in the U. Analysts, on lie other hand, feel the market reaction may be somewhat overdone. The issues arc undoubtedly complex and involve a fair bit of unfinished litigation. Beecham, for example, is still suing its main U. But Bristol and Beecham have both been on the receiving end under U. It comes, moreover, in the wake of average amoxy- cillin price cuts since July of roughly 20 per cent. This has already been noted by dose ob- servers of the U. In the short term, despite some loss in market share. Although longer term growth prospects from the U. After sliced bread Now that the loss-making bread baking business is out of the way. A 98 Offer from Wm. Baird lapsed De Beers Dfd. Group Financial Gp. So loss elimination should be worth Elsewhere the milling division did better, and grocery products and meat are singled out as having done well. The one question for the market is haw quickly Spillers will restore its dividead. Last year when profits collapsed the dividend was slashed from 2. The market is banking on Spillers going some way to restoring the divi- dend this year. For the whole of last year losses in the U. This left group profits only. The problems seem to have been twofold. First, Mothercare j set up its U. The bulk of these were under 1. Secondly, the Mothercare management in the U. Strenuous efforts, including top management changes, are now going on to turn the pro- ject round. And meanwhile the stores operating under the Mothercare name are apparently doing well. Impressive though ' the Dow's losses have been in the last two weeks, they in fact understate the broad market decline, notably the routing of secondary stocks. The American Stock Exchange which hosts many' of the smaller, less capitalised companies, has seen its index tumble by a formidable 17 per cent front its peak in mid- September, while the Dow has suffered a more modest 9. On Thursday the Dow drew back by 9. But yesterday the decline quickened and the Dow dropped Technical analysts looking for a rainbow claim they are only mildly surprised at the slaughter. They point out that before the rally which started last April the market bad been seriously weakened by the Blue Chips — the IB Ms and Polaroid; of this world — while the smaller stocks had shown positive strength for most of last year. Meanwhile, away from the technicians' charts investors have found that the world is too much with them. In a brief but grisly recap the week's news has included a rise in commercial hanking prime rates to per cent, the. A 19th-century Russian novelist would have been strained to write a more depressing scenario There is as much scepticism in the U. Somewhat curiously there has been no attempt berc to cite the achievements of Britain's voluntary policy in justification for the new approach when on the surface the prospects for success are at least as good as they were in Britain. When they have been at their most negative they have simply assumed that conditions have been so bad. Perhaps the time has come again to search for a new meta- phor. The latest batch of quarterly results from North American groups show- a dis- tinct improvement over a year ago, if not in profits at least in sales. It is tempting to see the figures as the definite start nf a new trend, but the U. Another of the U. It came back into Ihe black in the second quarter and in the three months to No. The said Minute is in lhe wordsand figures following: Charles Barber, the Asarco chairman. Tm iD the same three mouths of Although zinc prices hafe been at lower levels than last year, lead demand has been strong and looks like remaining so. Further evidence nf the revival in the copper industry came from Freeport Minerals, whose profits in the September quarter jumped sharply to S7. In contrast the market for tin has been consistently strong. But this bas not provoked any consistent rise in Malaysian production, as the accamsnyiaz fable shows. A combination of higher taxes ami. Sprinkel publicly to disclose his intention of try- ing to put together a financial package allowing him to take- over the Wheal Jane tin mine in Cornwall. Sprinkel is an American entrepreneur, now resident in Derbyshire, and within the next two weeks he hopes to make Consolidated Gold Fields, the present owners, a definite offer. Ayer Hitam - Be r junta! Piran — Far East St. Piran— UK South Crafty Southern Malayan Tanjong Tong kah Harbour 42 40 Tronoh i Figures hi elude low-grade material f Not yet a puts are shown in metric tonnes of tin concentrates. Sept, Atut. Another metal which has strengthened its price despite the recession is molybdenum. A in ax. This level was reached four months before bullion peaked ar SI Political factors arc one reason for the poor general per- formance of golds. A good ex- ample of the short-term effects arose last week, during the visit of the five western foreign ministers to Pretoria. On tiie Wednesday, the gold price hit a new record las it then was of S Politics, however. Mine violence has died down, the mine- have obtained a better spread of labour, which five years ago ua. One overriding reason for the low level of interest in golds is ihe growth of ihe gold furures markets in the U. In these markets did not exist and physical gold ownership was only authorised early in So gold shares — U. Wnn trading in the U. This aside. The table shows U. The top 15 account for R5. However, the table shows the U. In addition to U. There has also been a massive flow of De Beers shares to the U. Johannesburg brokers estimate 10 per cent of De Beers is now held in the U. Except to the U. With the local institutions traditionally more interested in industrials than golds and the European investor virtually out nf the market for a mixture of political and financial. But the counter- pull of the future markets and the high existing level of U. Gcfinlrl 45 Western Holds. Brand 24 66 Pres. Totals 5, Tx Gar t m ore Fmxl Managers Lid. Eamonn Fingleton iks at ways to cut the cost. But unless you are care- you will lose about T per of your capital in dealing ; every time you switch, point is thai the dealing of a switch is often the difference between the r" price at which unit: He needs to choose a? Jives tors who get into units. These can he useful when the outlook for shares turns choppy. With some groups— Hambro. First switch free. Cutting the bother of Child Benefits ing in various types of equities Some unscrupulous brokers for bond investors. Barclays have been criticised recently for Unicorn bondholders cannot drumming up commission by link their investment to any encouraging unnecessary switch- particular unit trust but instead ing. Such brokers are unlikely it is put in a managed fund invested in a selection of the group's trusts. The managers vary the mix as market conditions dictate. Barclays, for instance, usually deducts in full the amount of any commis- for cent initial commission introducing new business. Indications for the second and third weeks arc that sales are lower, bill still very strong. The sudden sales surge re- flects the fact that -from October 1. Yet this jump in sales no- where near represents the full potential that could have taken place. There are about lira persons holding these certifi- cates, of whom over lm held the maximum holding before October 1. Looking to the immediate future' and the likely movement in the Retail Price Index, the official forecasts are that the year-on-year increase will re- main around S per cent for the next six months. But unofficial forecasts of r the rise of the RPI in the next 12 months vary from 6 to 12 per cent depending on the view on forthcoming wase settlements. Stockbrokers Phillips anti Drew, for example, is forecasting an They have lo watch patiently as the assistant goes through the palaver of stamping the benefit book, removing a counterfoil and counting our the money. The procedures are more appropriate in the days of the Penny Black than to an institu- tion that is now loading the world in such high-tech oology fields as Viewdata. From the outside, one would have though! And for working mothers in particular — who are more likely than stay-at-home wives to have their own bank accounts — the freedom from The need to traipse regularly to the Post Office would be a major boon. The Department of Social Security secs immense obstacles but it admitted this week that it has at least begun to study seriously the possibility of pay- ing the benefits by credit trans- fer where a mother so desiTes. The officials are also looking at the question of paying the Old Age Pension by credit trans- fer. The proportion of pen- sioners who bave bank accounts is lower than for the active population: No figures are available but the Department seems to fear that the savings to it later on would not com- pensate for the extra expenses early on. Two payment systems would involve a great deal of duplication of effort, the Depart- ment adds. But it is not as if the sums the Department is paying nui are small: The Depart- ment is pressing ahead with cninnilinc a report for ministers. But such a dogmatic view- point seems to assume that husbands and wives are con- stantly bickering over ihe house- keeping money. Any wife who is happy about the way the family's finances are shared out and does not agree that this view is typical will feel insulted that the Slate does nut allow her to make up her own mind on whether ihe money should be paid into a joint account Bankers feel that there may be one other reason why Social Security officials may be luke- warm about introducing credit transfers: But the cost of disposing of cash is a small price to pay for the extra convenience for mother and pensioners. The objective of the Allied Hambro Pacific Fund is to obtain long term capital growth by investing: It enables you to invest in Singapore, Malaysia and the Philippines Ji a ve offered considerable potential for economic growth. Now a number of countries in this area huve begun to achieve their potential, and in recent years have shown remarkable growth rates, often twice that of many major industrialised countries. Until a few years ago political instability in the area was a major deterrent to investment. But while there is some risk of recurring political disturbances, the political climate, particularly following China's policy of improving relations with its neighbours, now appears more stable. At the same time, there is now within this area a. Oriom Ovmm Couninm Svtiru Pacdtr 1-ld. Swim TropotOoi Lid. V Wimor Industrial Corn. Malayan Banking fifed. The objective is to maximise long-term capital growth; income is not a consideration. The improving prospects of the area have already been reflected in rising stock market values during this year. While we consider that the prospects for growth will continue, you should bear in mind tbat investment in these markets con be subject to substantial short-term fluctuations. We recommend therefore that an investment in the fund should form only part of a balanced portfolio. That having been said, the advantages of investing in South East Asian marked through an authorised unit trust are powerful indeed, in terms of simplicity, convenience and spread of risk. An investment in the fund should be regarded as a long-term one. Remember the price of units and the income from them may go down as well as up. You should also note that currency movements can significantly affect the value of your investment. How to invest Investment opportunity To take advantage of opportunities to invest in companies operating in this area of potential growth, and to avoid the pitfalls, the experience of full-time. The portfolio 'is currently heing invested in the shares of companies quoted or operating in Hong Kong. Singapore, Malaysia and the Philippines, including companies registered in London or elsewhere which. You will be allocated units to the full value of your remittance at the offer price ruling on receipt of your application. Units in the fund may also he acquired on a Tegular monthly basis. For further details complete and return the coupon below, ticking the appropriate box. Uni La may normally be bought and nofel on any Lw mrUnK to. SeUlnff units. RtcUMit oAn u. I wish to invest Sifegiunlf. Thr Trvrtoe u! Chorees- The offer nricr cvmnll. The charge is currently lS. Xtuun appltatlicBi is granted, umtholden fat the bail will be asked to approve the anffopnatemerease. J declare that I am over 18 sod am not resident outside the UK or other Scheduled Tern tones and that I am not acouinna die above units es the. If you ere unable to malic ihe residential declaration it should be deleted and the form lodged through your UK bank, stockbroker or solicitor. This Offer is not available to residents of the Republic of Ireland..

Human milk composition and infant growth. This review highlights relevant studies published between and Rin aoki porn etotic clips human milk composition and the association with infant growth. High-quality studies investigating how human milk composition is related to infant growth are sparse. Recent observational Furthermore, some observational studies examining human milk oligosaccharides and hormone concentrations suggest functional relevance to infant growth For human milk micronutrient concentrations and microbiota content, and other bioactive components in human milk, the Rin aoki porn etotic clips with infant growth is still speculative and needs further investigation.

The included studies in this review are all limited in their methodological design and methods but have Human Capital Composition and Economic Growth. The objective of this paper https://humiliation.revia2018.host/num11101-foju.php to analyze the effect of various compositions of human capital on economic growth. We construct alternative measures of human capital composition using five fields Rin aoki porn etotic clips study.

In each instance, the measure represents the number of graduates in the respective field as Rin aoki porn etotic clips percentage of all graduates. The measures are as…. Employment growthhuman capital and educational levels. We examine to what extent different labour competences and capabilities relate to municipal employment growth using nine stratified, educational categories as proxies for different levels of human capital.

Dividing municipalities into four spatial Contemporary studies in urban and regional development stress the importance of large city-regions as key places in modern capitalism taking the form of agglomerations of economic activities by industries, firms and highly skilled people. In this article, we challenge the strong focus on academic Directory of Open Access Journals Sweden.

Full Text Available Recognizing the importance of infl uence exerted by human capital oneconomic growth of a country, to base decisions regarding the need to invest in such type of capital there are conducted studies and used different models for analysis related to a series of macroeconomic and demographic indicators.

We present the main indicators and dynamics of human capital, placedin the economic context of Romania, with reference, in bringing out statistics data, to Rin aoki porn etotic clips average period of time between characterized at macroeconomic level, both by recession and economic growth periods.

Sex bucks Watch Video wierd nude. AMPK regulation of the growth of cultured human keratinocytes. Saha, Asish K. In the present study, we examined the relationship between AMPK activation and the growth proliferation of cultured human keratinocytes and assessed whether the inhibition of keratinocyte growth by vitamin D involves AMPK activation. In addition, we explored whether the inhibition of keratinocyte proliferation as they approach confluence could be AMPK-related. Like most cells, the growth of keratinocytes diminished as they approached confluence. Both showed nitrogen retention on balance studies, the older second patient to a marked degree. In the younger patient, height increased from The rate of growth approximately doubled during the first two treatment periods as compared with the pre-treatment rate. In the second older patient hgh was administered 5 mg daily intramuscularly for 21 out of 33 months. Growth from This increased growth rate occurred during the post-puberty deceleration phase. Transient adolescent gynecomastia appeared in Case 2. No local or general toxic effects were noted. These results are suggestive, but whether or not the eventual height of an achondroplastic dwarf can be significantly altered must await further studies. ImagesFigure 1. Figure 2. Selection and characterization of a human neutralizing antibody to human fibroblast growth factor Compelling evidences suggest that fibroblast growth factor-2 FGF-2 plays important roles in tumor growth , angiogenesis and metastasis. Molecules blocking the FGF-2 signaling have been proposed as anticancer agents. Through screening of a human scFv phage display library, we have isolated several human single-chain Fv fragments scFvs that bind to human FGF After expression and purification in bacteria, one scFv, named 1A2, binds to FGF-2 with a high affinity and specificity, and completes with FGF-2 binding to its receptor. In a set of vitro assays, it inhibited various biological activities of FGF-2 such as the proliferation, migration and tube formation of human umbilical vein endothelial cells. More importantly, hIgGA2 antibody also efficiently blocked the growth while inducing apoptosis of glioma cells. For the first time, we generated a human anti-FGF-2 antibody with proven in vitro anti-tumor activity. It may therefore present a new therapeutic candidate for the treatment of cancers that are dependent on FGF-2 signaling for growth and survival. Epidermal growth factor receptor in primary human lung cancer. Cell membranes were prepared from 12 human lung cancers for the study of the expression of epidermal growth factor receptors EGFR. The dissociation constants of the high affinity sites were identical, 1. These results suggest that EGF and its receptor may play a role in the regulatory mechanisms in the control of lung cellular growth and tumor promotion. A Big Bang model of human colorectal tumor growth. What happens in early, still undetectable human malignancies is unknown because direct observations are impractical. Here we present and validate a 'Big Bang' model, whereby tumors grow predominantly as a single expansion producing numerous intermixed subclones that are not subject to stringent selection and where both public clonal and most detectable private subclonal alterations arise early during growth. Genomic profiling of individual glands from 15 colorectal tumors showed an absence of selective sweeps, uniformly high intratumoral heterogeneity ITH and subclone mixing in distant regions, as postulated by our model. We also verified the prediction that most detectable ITH originates from early private alterations and not from later clonal expansions, thus exposing the profile of the primordial tumor. Moreover, some tumors appear 'born to be bad', with subclone mixing indicative of early malignant potential. This new model provides a quantitative framework to interpret tumor growth dynamics and the origins of ITH, with important clinical implications. The liver taxis of receptor mediated lactosaminated human growth hormone. Radiography imaging is used to assess liver taxis mechanism of anti-dwarfism drug lactosaminated human growth hormone L-rhGH. Both L-rhGH and rhGH labelled with I are used to study their biodistribution in animals including rabbits, cocks and rats. The results show that L-rhGH is of specific hepatic targeting property, and the maximum hepatic concentration rate is Its hepatic binding is receptor mediated. Expression of epidermal growth factor receptors in human endometrial carcinoma. Little data exist on the expression of epidermal growth factor receptors EGF-Rs in human endometrial cancer. EGF-R was identified on frozen tissue sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the external domain of the EGF-R. Seventy-one percent of the carcinomas expressed positive EGF-R immunoreactivity. In general, staining was most prominent Radioimmunological activity of 22K variant of human growth hormone. From a preparation of human growth hormone its integral variant hGHK was isolated by isoelectric focusing, having a pI of 5,20 and relative mobility Rm of 0, in the polyacrylamide gel electrophoresis. Several experiments for the characterization of the isolated variant were carried out. The immunological properties was tested by radioimmunoassay RIE , in which the activity of the isolated variant and the activity of the total preparation were compared. The dose response-curves obtained by RIE were found to be considered parallels p [pt. To determine the rate of growth of these colonies, recipes were developed using CL-Quant software which enables users to extract various types of data from video images. To accurately evaluate colony growth , three recipes were created. The first segmented the image into the colony and background, the second enhanced the image to define colonies throughout the video sequence accurately, and the third measured the number of pixels in the colony over time. The three recipes were run in sequence on video data collected in a BioStation CT to analyze the rate of growth of individual hESC colonies over 48 hours. To verify the truthfulness of the CL-Quant recipes, the same data were analyzed manually using Adobe Photoshop software. When the data obtained using the CL-Quant recipes and Photoshop were compared, results were virtually identical, indicating the CL-Quant recipes were truthful. The method described here could be applied to any video data to measure growth rates of hESC or other cells that grow in colonies. Short-term effects of recombinant human growth hormone and feeding on gluconeogenesis in humans. After a short-term fast, lactating women have increased rates of glucose production but not gluconeogenesis GNG despite relative hypoinsulinemia. We explored the effects of non-insulin-dependent increase in glucose utilization and recombinant human growth hormone rhGH on glucose production, glyc Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone. The growth hormone GH -deficient dwarf rat was used to investigate recombinant human rh GH-induced bone formation and to determine whether rhGH facilitates simultaneous increases in bone formation and bone maturation during rapid growth. The GH group received 1. Biochemical, morphological, and X-ray diffraction measurements were performed on the femur middiaphysis. Adaptation to statins restricts human tumour growth in Nude mice. Statins have long been used as anti-hypercholesterolemia drugs, but numerous lines of evidence suggest that they may also bear anti-tumour potential. We have recently demonstrated that it was possible to isolate cancer cells adapted to growth in the continuous presence of lovastatin. These cells grew more slowly than the statin-sensitive cells of origin. In the present study, we compared the ability of both statin-sensitive and statin-resistant cells to give rise to tumours in Nude mice. HGT-1 human gastric cancer cells and L50 statin-resistant derivatives were injected subcutaneously into Nude mice and tumour growth was recorded. At the end of the experiment, tumours were recovered and marker proteins were analyzed by western blotting, RT-PCR and immunohistochemistry. L50 tumours grew more slowly, showed a strong decrease in cyclin B1, over-expressed collagen IV, and had reduced laminin , VEGF and CD34 levels, which, collectively, may have restricted cell division, cell adhesion and neoangiogenesis. Taken together, these results showed that statin-resistant cells developed into smaller tumours than statin-sensitive cells. This may be reflective of the cancer restricting activity of statins in humans , as suggested from several retrospective studies with subjects undergoing statin therapy for several years. Homologous radioimmunoassay for human epidermal growth factor urogastrone. Epidermal growth factor EGF , a polypeptide hormone originally discovered in the mouse submaxillary gland, stimulates growth in a variety of tissues in several species. This hormone has recently been identified in human urine. In general, levels were similar to those recently reported using a heterologous RIA system. Excretion by females taking oral contraceptives was significantly greater Several of those with very low values had histories of alcohol abuse. Excretion by patients with Cushing's syndrome was normal. Patients with psoriasis or recovering from major burns excreted both abnormally high and abnormally low levels of RIA-hEGF, with no obvious correlation to their clinical condition. And, hair re- growth promotion in the gold threadimplanted mice were significantly higher than that in PGA thread group on day 11 after depilation. In particular, the skin tissue of gold thread-implanted mice showed stronger PCNA staining and higher collagen density compared with control mice. Effect of temperature on the radioiodination of human growth hormone. Studies have been undertaken to assess the effect of altering the temperature at which human growth hormone is radioiodinated on the incorporation of I and the immunoreactivity and stability of the labelled hormone. Employing highly purified monomeric hormone it proved possible, by the iodogen procedure, to prepare a labelled product of high specific activity irrespective of temperature. However, in radioiodinations performed at ambient temperature 20 to 25 degrees significant amounts of the labelled hormone were in an aggregated form which was less immunoreactive than the I-labelled monomeric hormone. From a set of 31 three-dimensional CT scans we model the temporal shape and size of the human mandible. Each anatomical structure is represented using semi-landmarks, and mapped into Procrustes tangent space. Exploratory subspace analyses are performed leading to linear models of mandible The traditional variance analysis results in a one-dimensional growth model. However, working in a non-Euclidean metric results in a multimodal model with uncorrelated modes of biological variation. The applied non-Euclidean metric is governed by the correlation The generative models are compared, and evaluated on the basis of a cross validation study. The new non-Euclidean analysis is completely data driven. It not only gives comparable results w. IL-8 had no effect. Epidermal growth factor and its receptors in human pancreatic carcinoma. The role of epidermal growth factor EGF in oncogenesis and progression of malignant tumors is a subject of vast interest. In this study, radioimmunoassay and radioreceptor assay of EGF were established. EGF contents in malignant and benign pancreatic tumors, in normal pancreas tissue, and in culture media of a human pancreatic carcinoma cell line were determined. EGF receptor binding studies were performed. It was shown that EGF contents in pancreatic carcinomas were significantly higher than those in normal pancreas or benign pancreatic tumors. EGF was also detected in the culture medium of a pancreatic carcinoma cell line. The binding of I-EGF to the pancreatic carcinoma cells was time and temperature dependent, reversible, competitive, and specific. Scatchard analysis showed that the dissociation constant of EGF receptor was 2. Human milk fortification strategies for improved in-hospital growth of Human milk is the preferred feed for preterm infants, yet it may need to be fortified for optimal growth and development. Standard fortification of human milk seldom meets the recommended intake of protein, leading to inadequate post-natal growth. This article aims to critically review different human milk fortification Developmental regulation of human truncated nerve growth factor receptor. DiStefano, P. Urine samples were collected from 70 neurologically normal subjects ranging in age from 1 month to 68 years. By using this sensitive two-site radiometric immunosorbent assay, NGF-Rt levels were found to be highest in urine from 1-month old subjects. No evidence for diurnal variation of adult NGF-Rt was apparent. Pregnant women in their third trimester showed significantly elevated urine NGF-Rt values compared with age-matched normals. These data show that NGF-Rt is developmentally regulated in human urine, and are discussed in relation to the development and maturation of the peripheral nervous system. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Human papilloma virus HPV types 16 and 18 are most commonly associated with cervical carcinoma in patients and induce immortalization of human keratinocytes in culture. HPV has not been associated with breast cancer. This report describes the immortalization of normal human mammary epithelial cells 76N by plasmid pHPV18 or pHPV16, each containing the linearized viral genome. Transfectants were grown continuously for more than 60 passages, whereas 76N cells senesce after passages. The transfectants also differ from 76N cells in cloning in a completely defined medium called D2 and growing a minimally supplemented defined medium D3 containing epidermal growth factor. HPV transfectants do not form tumors in a nude mouse assay. It is concluded that products of the HPV genome induce immortalization of human breast epithelial cells and reduce their growth factor requirements. This result raises the possibility that HPV might be involved in breast cancer. Furthermore, other tissue-specific primary epithelial cells that are presently difficult to grown and investigate may also be immortalized by HPV. Expression of the human growth hormone variant gene in cultured fibroblasts and transgenic mice. The nucleotide sequence of the human growth hormone variant gene, one of the five members of the growth hormone gene family, predicts that it encodes a growth hormone-like protein. The growth hormone variant protein expressed in transiently transfected L cells is distinct from growth hormone itself with respect to reactivity with anti- growth hormone monoclonal antibodies, behavior during column chromatography, and isoelectric point. Transgenic mice expressing the growth hormone variant protein are 1. Algorithmic complexity of growth hormone release in humans. Most hormones are secreted in an pulsatile rather than in a constant manner. This temporal pattern of pulsatile hormone release plays an important role in the regulation of cellular function and structure. In healthy humans growth hormone GH secretion is characterized by distinct pulses whereas patients bearing a GH producing tumor accompanied with excessive secretion acromegaly exhibit a highly irregular pattern of GH release. It has been hypothesized that this highly disorderly pattern of GH release in acromegaly arises from random events in the GH-producing tumor under decreased normal control of GH secretion. Using a context-free grammar complexity measure algorithmic complexity in conjunction with random surrogate data sets we demonstrate that the temporal pattern of GH release in acromegaly is not significantly different from a variety of stochastic processes. In contrast, normal subjects clearly exhibit deterministic structure in their temporal patterns of GH secretion. Our results support the hypothesis that GH release in acromegaly is due to random events in the GH-producing tumorous cells which might become independent from hypothalamic regulation. Clinical impact of biotechnology has been constrained by the limitations of traditional hypodermic injection of biopharmaceuticals. Microneedle patches have been proposed as a minimally invasive alternative. In this study, we assess the translation of a dissolving microneedle patch designed for simple, painless self-administration of biopharmacetucials that generates no sharp biohazardous waste. After manual insertion into the skin of hairless rats, hGH pharmacokinetics were similar to conventional subcutaneous injection. After patch removal, the microneedles had almost completely dissolved, leaving behind only blunt stubs. The dissolving microneedle patch was well tolerated, causing only slight, transient erythema. This study suggests that a dissolving microneedle patch can deliver hGH and other biopharmaceuticals in a manner suitable for self-administration without sharp biohazardous waste. Humanized versus murine anti- human epidermal growth factor receptor monoclonal antibodies for immunoscintigraphic studies. Morales, Alejo A. The mAb ior C5 that recognizes an antigen expressed preferentially on the surface of malignant and cytoplasm of normal colorectal cells was used as negative control. Among all organs significant accumulation was found in tumor 6. The immunoreactive fractions were found to be 0. Thus, we expect better results using the humanized mAb h-R3 for diagnostic immunoscintigraphy. The anti- human epidermal growth factor receptor EGF-R humanized antibody h-R3 IgG 1 , which binds to an extracellular domain of EGF-R, was used to evaluate the biodistribution on nude mice xenografted with A epidermoid carcinoma cell line. Immunoreactivity of 99m Tc-labeled mAbs was measured by enzyme linked immunosorbent assay on A cell line and the immunoreactive fractions determined by Lindmo method. Full Text Available In order to address the direction of causality between human capital and productivity growth in Nigeria, the study first investigated the pattern of productivity growth in Nigeria between and Following the endogenous growth model, which argued that technical progress, through an effective labor force, could lead to long-run growth which can be determined from within an economy; but it actually depends on the efficiency with which resources available to such an economy are utilized. This is against the exogenous growth model which emphasized that long-run growth can be attained by some unexplained technological progress, which is exogenous to any economy. Based on this controversy in literature, this study empirically determined the productivity growth in Nigeria, as well as the causal relation between human capital development and productivity growth in Nigeria using the Engle-Granger causality test. The results revealed that productivity growth has been very low and unstable in Nigeria as it oscillated between In addition, the nexus between human capital and productivity growth was examined. The findings revealed that while productivity growth caused human capital development, human capital development did not cause productivity growth. Metabolic clearance and production rates of human growth hormone. No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's. The MCR was relatively constant from day to day and within the day when subjects were evaluated in the supine position. These results were contrasted with the MCR of HGH observed in a small number of patients with altered thyroid function or diabetes mellitus. As growth hormone possesses anabolic properties that are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I IGF-I its specific binding proteins Mathematical modelling of the growth of human fetus anatomical structures. The goal of this study was to present a procedure that would enable mathematical analysis of the increase of linear sizes of human anatomical structures, estimate mathematical model parameters and evaluate their adequacy. Section material consisted of 67 foetuses-rectus abdominis muscle and 75 foetuses- biceps femoris muscle. The following methods were incorporated to the study: Size changes can be described with a segmental-linear model or one-function model with accuracy adequate enough for clinical purposes. The interdependence of size-age is described with many functions. However, the following functions are most often considered: The best adjustments to measurement results were observed in the exponential and Gompertz's models. The growth pattern of the human intestine and its mesentery. It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visualization techniques. We distinguished 3 generations of midgut loops. The topography of primary and secondary loops was constant, but that of tertiary loops not. The orientation of the primary loop changed from sagittal to transverse due to the descent of ventral structures in a body with a still helical body axis. The 1st secondary loop duodenum, proximal jejunum developed intraabdominally towards a left-sided position. The 2nd secondary loop distal jejunum assumed a left-sided position inside the hernia before returning, while the 3rd and 4th secondary loops retained near-midline positions. Intestinal return into the abdomen resembled a backward sliding movement. Only after return, the 4th secondary loop distal ileum, cecum rapidly "slid" into the right lower abdomen. The seemingly random position of the tertiary small-intestinal loops may have a biomechanical origin. The interpretation of "intestinal rotation" as a mechanistic rather than a descriptive concept underlies much of the confusion accompanying the physiological herniation. We argue, instead, that the concept of "en-bloc rotation" of the developing midgut is a fallacy of schematic drawings. Primary, secondary and tertiary loops arise in a hierarchical fashion. The predictable position and growth of secondary loops is pre-patterned and determines adult intestinal topography. We hypothesize based on published accounts that malrotations result from stunted development of secondary loops. Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis. Twenty consecutive patients with cirrhosis were randomized to recombinant human growth hormone Norditropin, 4 I. The serum concentrations of insulin-like growth factor-I in the recombinant No significant changes were seen in the area under the curve for biochemical liver function tests. 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Are you in good physical and mental health and free from the effects of any previous illness or accident? If not please give details. Hf Registered No. Birmingham, has been so r great. And especially so if he was interested in a Ford. The panel of: When they did their rounds on Press day. This year's entries were from Western Europe. Soon 1BC. U1 — some may think belatedly — will consider wheilier or not to open the contest a: There arc live categories for cars— saloons, estates, hatch- MQTGE CASS backs- limousines and sports models — plus a couple for motor caravans and one for special bodywork. Other categories which hardly concern the motorist are for vehicles ranging from mini-buses to tractor cabs, juggernaut trailers to double-deckers. As a motoring correspondent, my judgment of a car has always been based more on the way it goes than the way it looks. Sorting out the cars most deserving of gold and silver awards from exhibits standing still or at most re- volving on turntables demanded new criteria. Judging a car objectively when it t; out of its element is curiously difficult. Taking account of general exterior and interior design and finish is fairly straightforward. But general visibility, accessibility oi controls and, above all, com- fort. These relate more realistically to a car in motion, run at rest. For example, a driving seat that may look mag- nificently comfortable in the snow. That I know from experience. Might it not also be risky to award mark? My job. After hours of i. Vauxhali Carlton and Rover I am still wondering why the Rover was not classified as a hatchback. Why the Renault 18 and Royale for golds? The Renault scored above-average for every- thing except visibility. It looked elegant on the stand, with a faultlessly colour matched interior, one-piece moulded headlining aud a flat-floored boot uncluttered by the spare wheel. That lives underneath in a cradle and can be wound dawn by the jack handle with- out disturbing the luggage. Badges apart, the Royale is an Opel Senator, though with less power and a lower price. It looks in every way an urbane carriage for the top executive.: Of the runners-up. The Vauxhali Carlton offers many of the facilities of the Royale at half he price. And the Rover gained marks lor its colossal luggage accom- modation and convenient lifting tail hut lost some for poor rear- ward visibility and. Does anyone else share our feeling that this otherwise admirable motor car would be improved by a higher roofline and deeper windows? In Seve Ballesteros. Nick Faldo, Ken Brown. Howard Clark, and Mark Janies a poten- tially brilliant nucleus for future Ryder Cup teams has emerged — and not a moment too soon. One can only hope that when Europeans are allowed to play for our team next Septem- ber for the first time at The Greenbrier, White Sulphur Springs. West Virginia, a resort complex course recently re- designed by Jack Nicklaus. But a spy. Andrews by the most heart-warming ovation any golfer could wish to receive. This was the best moment of the year for me. This latter event is definitely the high-spot of the golf spectator's year. Nothing could better emphasise the gulf that exists between the American and the European tours than the fact that Hayes immediately won both the Italian and French Open titles. Before Hayes, it had been Clark who had dominated the Iberian peninsula. Having won the Portuguese Open from Brian Barnes on a Penina course that had previously des- troyed him. But Clark's, victory in Madrid was the most satisfying, in that he left Jose Maria Canizares — whose 9 holes in 27 shots during the Swiss Open was possibly the greatest achievement of the season — and Ballesteros in his wake. But the latter Spanish prodig ' brought -the golf world to his feet by winning at Greensboro. North Carolina — a fantastic performance, since he was 10 shots behind the leaders, with 36 to play. Ballesteros's really golden period, however, followed bis miserable failure at St. When Seve won the German. Club pro- fessional Brian Waites of Notts. Outstanding In the amateur ranks. Peter aJcGvoy was outstanding as a rare successful defending British champion. He per- formed with distinction in the U. Ohio, in the World Series of Golf. But by the time he got to Pacific Harbour. Fiji, for the Eisenhower Trophy, he had gone off the boil. British were made to look- sorry, chiefly because the outstanding American ' amateur of this and many former years. Bobby Clampett. I am grateful and feel that the time has not been wasted. X hope that these two hands, which occurred last week, will appeal to you. Here is the first: East came in with two hearts. West led the three of hearts, taken by the Ace, and East returned the nine of diamonds. After some thought I let this run. If the finesse was wrong. I had a loser in each suit, and my only hope of getting home appeared to be an endplay. I dismissed the possibility of a diamond ruff. I had to assume that East had at least two cards in the suit— if she had a single- ton. I was not going to make the contract anyhqw. West won with the King, returning the'two— I -was thank- ful to see East following suit — and I won in hand. When East dropped the Queen, it looked as if her hand pattern was S- 6 - 2 - 2. I made my other two j diamonds, on which East dis- carded two. East was securely endplayed, and her forced heart return gave me the ruff discard for which I had planned, allowing me to dispose of my losing dub while dummy ruffed. The second hand was far simpler, but it has more than one point of interest: West overcalled with two diamonds — now that is a bid with which one might find fault— and my partner doubled for penalties. This, of course. When West led the heart ten, I wan on the table, cashed the spade Ace, and returned the six of diamonds. East played low, and the nine won. Now West, who had found the best lead, instead of continuing with his other heart— his partner had dropped the eight at trick one — made the senseless return of a low diamond, which at pairs would have been disastrous. Ruffing in hand. Ten tricks were now certain, but I led ' the club five and finessed dummy's nine. East won with the King and led the Queen of hearts— too late. I won with the Ace. I did not care which defender had the Queen of clubs. 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S deteriorated further Egyptians knew of Israel's mien- months official price freeze and ' today as the two countries ex- lion t0 enlarge toe existing settle- is bound to fan the flames of changed mutual recriminations menLs, even while observing the inflation, which at some 60 per ' and accused each of bad faith, freeze on the construction of new cent in the past twelve months,. Sharplv worded notes criticis- ones. Yifiael Yadin. Politicians from the lead- rhai funner U. S, Secretary of with Mr. Israeli parties rushed to St;. Begin this P re. Sadat for the prize, man? Hu cent from a year earlier. Imports totalled CS4. September exports tn the U. Mur member loday. Guido Brunner. This is tantamount to saying that it is not going to guarantee the parity nf the Irish pound -with sterling to which it is linked as far as some trans- actions are concerned. The hank has not spelt out its reasons for taking this action. The hank is preparing to reassure businessmen and busi- nesses that it has not made the move because it expects a break between the two pounds in the foreseeable future. THE OECD Council has given the go-ahead lo the setting-op of a permanent Steel Commit- tee to study the problems of the world steel industry and to work out common solutions. Agreement has also been reached to. I will also study the re- adaptation of labour, domestic pricing and supply policies. Government export credits Tor steel plant and equipment, and domestic policies to sustain steel production and demand in times of crisis. The participants in the Steel Committee have agreed to tbe following multilateral guide- lines: No steel policies should be incoiudsfent with the pravistaas of GATT. Measures in this flpid should be liberalised or abandoned altogether, as conditions im- prove. Tigercat surface-to-air OerllKon 20mm anti: Addition - equipment likely to be airlifted into I. According to unofficial esti- mates. The military assistance forms part of a wider financial 3? The Foreign for President forces, not Rhodesian guerrillas, -t — that it would only. Britain, is also examine mg the -possibility of refurbish- ing these missiles. Repair work Is eon- or two technicians to Lnsaka. Eldon Griffiths, -the Con- servative MP. Kauntfa five Front Linq states rr. Da r-es-Sai 3am. Kauii da's. Security moves to convene an aL-p;.: Zambia is reciini under the twin burdens of. Kaunda was highly Pr. People's dais. Icancr'i position; without preconditions. MS V have crossed: Reuter adds: Tanzantim ster Mr. Republican' party pmtrt.: The news that these com- panies, which were not named. West in a manner which wtll also resumed assistance tn 1H I; 11? Turkey insists that the existence an alumina operation, w, ff ' The Greek Government's pro- of NATO responsibilities should At the same time agriculture has.. However, discus- in the m. Oct The eluding an year-old boy; and both tbe continued violence came on the a small town in Fars province, officials, eve. None of these Aftir? It is no exploitation of uranium. The-V gradual , change of SMHf: Pochiney and Montedison. The other bauxite Aye.? Richard Cmr. Yugoslav Jn many other pointed out that the wrangle over. T-t jn-ndmj. Schmueeker made were: There is nothing con- jirportr authority and did noi. This is certainty the case crete -on the cards right now. CAV was In supply j n Britain. The car Operations woulu - -. Robert Sheldon, Financial! West and Audi vehicles, at Milton Government Tor instance, in laundries with overtime pushing the nut he taxable. Mi rv: If-, rights with tin. Scandinavian Airlines istarled. All have refused. The original intention two years ago was that the VW plant would assemble up to B r E nioim day. Sheldon brought a flood of applications from companies tickets for their Yesterday British Rail said that the statement accelerated a process which started about three! Plans are already being creases. Sir Geoffrey Howe, month. Conservative earlier thLs i. He made it clear, however, that he believed Arm. He preferred to stress freedom from government inicrferenci? John Paraue. Pardoe said Britain had 1 1 pea n bu- again. Lf we did not join Government in a difficult uur partners iu the system in linn. A Commons debale the New Year we would be been promised on the Euro- forced sooner or later to accept a Monetary System when a a i-mninan currency fashioned by siun is taken in December others. John Collins, managing director of Park West Motors, [ford. Essex, which imports Toyota cars, was delighted, if not a little surprised, by ihe news of ihe loan which will enable him lo buy xi new garage and. The corporation was 3 little coy about the deal. This, departure mla imports financing was iustjfled largely on the hasis of Mr. Collins be-. Collins did nut import Tuyotas. It said: Coilins said that when he applied for the loan he had expected the nature of hfs trade to be a problem. Finance had been difficult to find, but. Peter Foden-Pattin-: Conservative sun. Minet Agencies, and for Thanei East, about the Mr. Confidence was also expressed m Mr. Bernard Wex. The dispute over productivity is to be ihe subject of talks with Mr. It has also been the cause of warnings by the construction company that if payments con- tinue- to he withheld it might be forced to abandon the pro- ject, which. British Bridge Builders ruled twu weeks ago that if the Free- man Fox targets were not met the cable spinners would lose bonus payments equivalent lo about one third of weekly earnings. Haydon Glen, clerk to the Board, said that outstanding issues in the dispute would have to be- settled by arbitration or in the High Court. British Industry indicated last The campaign was formed in night that ii took seriously pro- response to a Labour document, posals by sections of the Labour suggesting a National Construc- Party for nationalisation of the tion Corporation on the lines of building industry. Erie Heffer, thai Labour should argue for step-by-slep public ownership of the construction industry. However, the Labour Party planned nationalisation. Water workers. The employer f had to provide the season ticket years ago and most annual sea- son tickets were now bought. Lins it Dispute delays frigate launch which would not be cashable by the employee, and he could not reimburse him for a ticket already bought. The frigate represent a key public sector Brilliant was to have been group in the low-pay area which launched next week. British Finally, the employee's earn- Mr. The Inland Revenue said yesterday that additional qualifi- cations. And it was likely most of the Discussion ranged round im- proving productivity by natural wastage. The management is stilt seeking to reduce the labour force by several thousand. Talks on this are At yesterday's meeting of Iho expected to take weks. The question of what cate- gories of workers make up ihe grades — and their rates — has stili not been settled. Saturday night shift, it added. Heffer was ownership, as the TUC had pru- addressmg. TASS, the engineering sluff union, yesterday issued a strong denial of charges reported to have been made last weekend by Mr. Michael Edwardes. BL chairman. TASS national lift. He Is ton. Rudolph Agnew, deputy chairman, said yesterday that the study would be finished in a matter of weeks. The venture would be on a small scale, producing less than half the amount of tin -of Wheal Jane, near Truro. Wheal Jane had an output of That mine is now on a care- and-malatenance basts after production. Robert L. Sprinkel— bis reluctance to accept Government money and the fact that he is willing tu put his own money ih, H Said Lord Erroll of Hale, the ehairman. Bat he held to the basic Gold Fields position on Wheal Jane: Bnt Lord Errol! As far as other Cornish activities are concerned,. Gold Fields is evaluating the results of drilling at two neglhbonring sites. ICI said yesterday that it did not yet have firm plans for the site, but it could follow the pattern of its biggest petro- chemicals site at Wilton on Teeiside. Products could include ammo nia and methanol— derived from natural gas — as wel-1 as oiher basic petrochemicals and down- stream products such as plasucs and fibres. It is also involved in exploration pro grammes on various parts of the UK continental shelf In the North Sea and to the west oF the Shetlands. It has developed more than 1. Il is thought however, that ICI is anxious not to concentrate its resources too heavily In one area. It has carried out land and seabed surveys at an estuary site in Tayside, Scotland. The site is at Barry Buddon. The company is also under stood to have investigated the Humber estuary in England. Both the Humber and Tay offer sites with fiat land and access to. The com puny has held a series of dis- cussions with the Scottish Office shout the Tayside location. First news of the plan has already brought mixed reactions from local interests on Tayside. Dundee has high unemployment It might therefore be expected 3 hili 1 in spa,n - The deposit certificates trial. He was jointly charged. Felicio Morelia, the former Banking Corporation and its head of both international Bank, associated company, European ing and European and Arabian, and Arabian Bank, both regis- who was jailed for three years tered in Anquilia. Unterlaggauer has prison sentence at the Old Bailey, spent 12 months in custody, he Dr. Heinrich Peter Unlertag- will be released on Honda when gauer, born In Austria, had a riepnrtatinn order will be con- pleaded guilty to charges of issu- sirlcrert. He claims io have a ing false certificates of deposit job awaiting him in Germany, in order to acquire seven hotels Mr. Joseph Khalife is still on in Spain. The deposit certificates trial. He Detective Chier Inspector Roy has pleaded no't guilty-. Elsey, he admitted signing 15 European and Arabian Bank certificates — together with has no connection with the another former employee of European Arab Bank group International Banking Corpora- Industrial Banking Cornoration" non who has since left the UK. Uo terlaggauer's sentence the c ame name. EG Commission to make their eipalities: Most of the steel in an average British car body is sheet steel. There was little to cheer in the silt market either, as a further rise in U. Interest rates British interest rates are still high enough to attract inflows from the United States, even after the most recent rise in the U. As the forward discount on ster- ling has shrunk almost to par. On a simpler level, it does seem that confidence in sterling, as against lack of confidence in the dollar, has been growing over the last week, with the foreign exchange markets appealing rather less worried about news on the labour front. There has been some nervous- ness i hat the Bank of England might intervene to stop sterling rising fun her. Next week the official cur- rency reserve figures for October will be published, and they are expected to show that the Bank's intervention has been limited. But any sign aF funds flowing heavily into London could be worrying to the markets, unless of course foreign money flows into gilts and encourages the home-based institutions tu jump in too. At the moment, though, short money rates are so high that they weaken the inducement to commit money to gilts. Drug problems Beecham's share price took a rumble last week on news that the company may bo forced to cut its drug prices further in the U. Analysts, on lie other hand, feel the market reaction may be somewhat overdone. The issues arc undoubtedly complex and involve a fair bit of unfinished litigation. Beecham, for example, is still suing its main U. But Bristol and Beecham have both been on the receiving end under U. It comes, moreover, in the wake of average amoxy- cillin price cuts since July of roughly 20 per cent. This has already been noted by dose ob- servers of the U. In the short term, despite some loss in market share. Although longer term growth prospects from the U. After sliced bread Now that the loss-making bread baking business is out of the way. A 98 Offer from Wm. Baird lapsed De Beers Dfd. Group Financial Gp. So loss elimination should be worth Elsewhere the milling division did better, and grocery products and meat are singled out as having done well. The one question for the market is haw quickly Spillers will restore its dividead. Last year when profits collapsed the dividend was slashed from 2. The market is banking on Spillers going some way to restoring the divi- dend this year. For the whole of last year losses in the U. This left group profits only. The problems seem to have been twofold. First, Mothercare j set up its U. The bulk of these were under 1. Secondly, the Mothercare management in the U. Strenuous efforts, including top management changes, are now going on to turn the pro- ject round. And meanwhile the stores operating under the Mothercare name are apparently doing well. Impressive though ' the Dow's losses have been in the last two weeks, they in fact understate the broad market decline, notably the routing of secondary stocks. The American Stock Exchange which hosts many' of the smaller, less capitalised companies, has seen its index tumble by a formidable 17 per cent front its peak in mid- September, while the Dow has suffered a more modest 9. On Thursday the Dow drew back by 9. But yesterday the decline quickened and the Dow dropped Technical analysts looking for a rainbow claim they are only mildly surprised at the slaughter. They point out that before the rally which started last April the market bad been seriously weakened by the Blue Chips — the IB Ms and Polaroid; of this world — while the smaller stocks had shown positive strength for most of last year. Meanwhile, away from the technicians' charts investors have found that the world is too much with them. In a brief but grisly recap the week's news has included a rise in commercial hanking prime rates to per cent, the. A 19th-century Russian novelist would have been strained to write a more depressing scenario There is as much scepticism in the U. Somewhat curiously there has been no attempt berc to cite the achievements of Britain's voluntary policy in justification for the new approach when on the surface the prospects for success are at least as good as they were in Britain. When they have been at their most negative they have simply assumed that conditions have been so bad. Perhaps the time has come again to search for a new meta- phor. The latest batch of quarterly results from North American groups show- a dis- tinct improvement over a year ago, if not in profits at least in sales. It is tempting to see the figures as the definite start nf a new trend, but the U. Another of the U. It came back into Ihe black in the second quarter and in the three months to No. The said Minute is in lhe wordsand figures following: Charles Barber, the Asarco chairman. Tm iD the same three mouths of Although zinc prices hafe been at lower levels than last year, lead demand has been strong and looks like remaining so. Further evidence nf the revival in the copper industry came from Freeport Minerals, whose profits in the September quarter jumped sharply to S7. In contrast the market for tin has been consistently strong. But this bas not provoked any consistent rise in Malaysian production, as the accamsnyiaz fable shows. A combination of higher taxes ami. Sprinkel publicly to disclose his intention of try- ing to put together a financial package allowing him to take- over the Wheal Jane tin mine in Cornwall. Sprinkel is an American entrepreneur, now resident in Derbyshire, and within the next two weeks he hopes to make Consolidated Gold Fields, the present owners, a definite offer. Ayer Hitam - Be r junta! Piran — Far East St. Piran— UK South Crafty Southern Malayan Tanjong Tong kah Harbour 42 40 Tronoh i Figures hi elude low-grade material f Not yet a puts are shown in metric tonnes of tin concentrates. Sept, Atut. Another metal which has strengthened its price despite the recession is molybdenum. A in ax. This level was reached four months before bullion peaked ar SI Political factors arc one reason for the poor general per- formance of golds. A good ex- ample of the short-term effects arose last week, during the visit of the five western foreign ministers to Pretoria. On tiie Wednesday, the gold price hit a new record las it then was of S Politics, however. Mine violence has died down, the mine- have obtained a better spread of labour, which five years ago ua. One overriding reason for the low level of interest in golds is ihe growth of ihe gold furures markets in the U. In these markets did not exist and physical gold ownership was only authorised early in So gold shares — U. Wnn trading in the U. This aside. The table shows U. The top 15 account for R5. However, the table shows the U. In addition to U. There has also been a massive flow of De Beers shares to the U. Johannesburg brokers estimate 10 per cent of De Beers is now held in the U. Except to the U. With the local institutions traditionally more interested in industrials than golds and the European investor virtually out nf the market for a mixture of political and financial. But the counter- pull of the future markets and the high existing level of U..

There were also highlighted indicators and dynamics, both at national and individual level. Nerve growth factor Rin aoki porn etotic clips human hemopoietic colony growth and differentiation. Nerve growth factor NGF is a neurotropic Rin aoki porn etotic clips necessary for the survival and growth of some central neurons, as well as sensory afferent and sympathetic neurons.

Much is now known of the structural and functional characteristics of NGF, whose gene has recently been clones. Since it is synthesized in largest amounts by the male mouse submandibular gland, its role exclusively in nerve growth is questionable.

These experiments indicate that NGF causes a significant stimulation of granulocyte colonies grown from human peripheral blood in standard hemopoietic methylcellulose assays. Depletion experiments show that the NGF Rin aoki porn etotic clips may be T-cell dependent and that NGF augments the colony-stimulating effect of supernatants from the leukemic T-cell Mo line. The authors conclude that NGF may indirectly act as Rin aoki porn etotic clips local growth factor in tissues other than those of the nervous system by causing T cells to synthesize or secrete molecules with colony-stimulating activity.

The biorhythm of human skeletal growth. Evidence of a periodic biorhythm is retained in tooth enamel in the form Rin aoki porn etotic clips Retzius lines.

The periodicity of Retzius lines RP correlates with body mass and the scheduling of life history events when compared between some mammalian species. The correlation has led to the development of the inter-specific Havers-Halberg oscillation HHO hypothesis, which holds great potential for studying aspects of a fossil species biology from teeth.

Yet, our understanding of if, or how, the HHO relates to human skeletal growth is limited. The goal here is to explore associations between the biorhythm and two hard tissues that form at different times during human ontogeny, within the context of the HHO. Rin aoki porn etotic clips, we investigate the relationship of RP to permanent molar enamel thickness and the underlying daily rate that ameloblasts secrete enamel during childhood.

Following this, we develop preliminary research conducted on small samples of adult human bone by testing associations between RP, adult femoral length as a proxy for attained adult stature and cortical osteocyte lacunae density as a proxy for the rate of osteocyte proliferation.

Results reveal RP is positively correlated with enamel thickness, negatively correlated Rin aoki porn etotic clips femoral length, but weakly associated with the rate of enamel secretion and osteocyte proliferation. These new data imply that a slower biorhythm predicts thicker enamel for children but shorter stature for adults. Our results develop the intra-specific HHO hypothesis suggesting that there is a common underlying systemic biorhythm that has a role in the final products of human enamel and bone growth.

Dimensiones del crecimiento humano Human growth dimensions. Se enfocan, igualmente, aspectos del desarrollo afectivo de la persona y su sinergia con las dimensiones del crecimiento ya mencionadas. This paper, based on the findings of pedagogic anthropology, highlights the essential endlessness of the human person -who is always prone to "being more" as a person- and considers to what extent education can enhance human growth.

The different stages of intellectual development are analyzed in some detail, emphasizing the critical sense and the adequate or inadequate ways of promoting such development through teaching.

The paper also studies the essential domains of the person's moral growth and the possibility, necessity and legitimacy conditions of an explicitly moralizing assertive influence as well as the links between moral education and civic education.

Likewise, aspects of the person's affective development and their synergy with the above mentioned growth domains are focused. Finally, some continue reading are made on the development of the religious domain and Rin aoki porn etotic clips educational importance.

Hematopoietic growth factors and human acute leukemia. Nonphysiological expansion of the leukemic population is Rin aoki porn etotic clips due to escape from control by these factors.

Proliferation in vitro of AML cells is dependent on the presence of one or several factors in most cases. The pattern of factor-dependency does not correlate with morphological criteria in individual cases, and may thus offer a new tool for classification of AML. Overproduction of undifferentiated cells is not due to abnormal expression of receptors for the stimulating factors acting at an immature level.

Rather, autocrine secretion of early acting lymphokines maintains proliferation of the leukemic clone. When looking at causes of leukemic dysregulation, yet undefined inhibitors of differentiation probably are of equal importance as dysequilibrated stimulation by lymphokines. Autodecomposition of radiolabeled human growth hormone.

Human growth hormone hGH was radiolabeled with I, using a gentle lactoperoxidase technique. The stability and decomposition products of this tracer were studied by frequent periodic analysis by Sephadex G chromatography on a long column. Monomeric I-hGH showed an exponential decline, with a half-life of 61 days. The main radioactive degradation product was iodide, which appeared with a fractional appearance rate of 0. Secondary degradation products were a series of radioactive oligomers of hGH, which appeared with an overall fractional rate of 0.

The kinetic data obtained should provide guidelines for the shelf-life and repurification schedule of radioiodinated polypeptides. Does It Slow Aging? Healthy Lifestyle Healthy aging Human growth hormone is described by some as the key to slowing the aging process. Before you sign up, get the Full Text Available The link between human capital and economic Rin aoki porn etotic clips still remains unexplained because of the measurement issues connected to the human capital stock. This study investigates the link between human capital stock and economic growth using Rin aoki porn etotic clips wealth index and ratio of engaged to actively disengaged employees as proxy for human capital stock.

Data from the global workplace and inclusive wealth reports are used in order to provide an international comparison of the link between human capital and inclusive wealth. Cross country comparison show human capital largerly contribute to the inclusive wealth formation. Formal education is important but also motivating working environment is needed to achieve sustainable economic growth.

The finding further indicates that standard human capital growth model should be revised Rin aoki porn etotic clips into the account variables addressing sustainable growth not just growth and environmental variables work conditions affecting read more capital stock.

Countries encouraging investments in the development of individuals both through formal education and inspiring work environments achieve higher sustainable economic growth.

Why higher economic growth cannot always enhance visit web page development. This paper studies why higher economic growth cannot always enhance human development. In general, these two dimensions have a strong and positive relationship, but some countries appear unable to balance this relationship.

As a consequence, there are some countries with high economic growth but sluggish human development progress. This paper studies how other factors besides GDP — women labor force participation, urbanization, and inequality - are correlated to human development.

I construct Rin aoki porn etotic clips, Economic Growth and Human Development: Evidence from Africa. This paper cuts adrift the mainstream approach to the legal-origins debate on the law- growth nexus by integrating both overall economic and human components in our understanding of how regulation quality and the rule of law lie at the heart of Rin aoki porn etotic clips and inequality adjusted human developments.

Findings summarily reveal that legal-origin does not explain economic growth and human development beyond the mechanisms of law.

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